Patents in Class 530/404

Matches 1 - 50 out of 281

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Match	Document	Document Title
1	RE40596	Rapamycin assay Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for...
2	7361516	Field of modular multifunctional ligands This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a...
3	7326776	Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises...
4	7320867	Linker compound, ligand, and producing method thereof A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or...
5	7282481	Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active...
6	7279562	Rapamycin conjugates Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for...
7	7279165	Amyloid β1-6 antigen arrays The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
8	7229782	Antibodies specific to multiple beta blockers and methods for their use The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies.
9	7208148	Chemically modified cytokines The invention concerns a derivative of viral regulatory protein or a fragment of viral regulatory protein or of the alpha interferon or a fragment of alpha interferon, which is carboxymethylated, a...
10	7205161	Polymer brushes for immobilizing molecules to a surface or substrate having improved stability Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with...
11	7195882	Monoclonal antibodies specific for buprenorphine and metabolites thereof The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine...
12	7166708	Process for preparing conjugate vaccines and the conjugate vaccines This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate,...
13	7161031	Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X 1 , g, R and R 3 are as defined herein.
14	7157561	Methods of inhibiting transmission of a costimulatory signal of lymphocytes Activated haptens useful for generating immunogens to the HIV protease inhibitor atazanavir, immunogens useful for producing antibodies to atazanavir, and antibodies and labeled conjugates useful...
15	7148029	Immunoassay for neonicotinyl insecticides The present invention provides immunogens for generating anti-neonicotinoid antibodies as well as antibodies, methods, reagents and kits for determining the presence of one or more neonicotinoid...
16	7132397	Bone morphogenetic protein antagonist based on the mature protein The purpose is to provide a mature protein having an antagonistic activity against bone morphogenetic proteins. The mature protein having an antagonistic activity against bone morphogenetic...
17	7128911	Antigen arrays for treatment of bone disease The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
18	7115266	Angiotensin peptide-carrier conjugates and uses thereof The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling...
19	7101980	Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
20	7048930	Expression of core-glycosylated HCV envelope proteins in yeast The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
21	7026134	Haptens, immunogens and antibodies to oxycodone and its metabolites Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional...
22	7011968	Fragments of virus protein 2 or 3 of the polyoma virus, used for transporting active ingredients The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid...
23	6964769	Molecular antigen array The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
24	6913936	Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of...
25	6814971	Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
26	6756041	Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At...
27	6677164	Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds The present invention provides biologically active linear polypeptides that possess a plurality of biologically active groups, methods employing such peptides to target molecules to cells, and...
28	6663869	Polyoxime compounds and their preparation A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is...
29	6649591	Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
30	6635434	Immunoassay for pesticides and their degradation products A hapten-polymer carrier complex was found to be useful for immunoassay purposes, specifically ELISAs, for the detection of pesticides and their degradation products in hydrosoil and ground water....
31	6632437	Immunogenic polysaccharide-protein conjugates containing poly α(2→8), α(2→9) NeuNAc capsular polysaccharides The present invention relates to a polysaccharide-protein conjugate. The invention also relates to a method of using the conjugate to prevent systemic infections. The invention further relates to a...
32	6602507	Synthetic peptides from streptococcal M protein and vaccines prepared therefrom Synthetic polypeptides from the conserved exposed region of streptococcal M protein are useful to prepare vaccines for oral or intranasal administration which will protect against streptococcal...
33	6593148	Cyanine dye compounds and labeling methods A novel cyanine dye having the formula is useful for labeling biological and nonbiological molecules.
34	6576746	Site-specific labeling of disulfide-containing targeting vectors A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and...
35	6548645	Immunoassay for 2-oxo-3-hydroxy LSD To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an...
36	6506885	Monoclonal antibodies to the drug tilmicosin and a method for detecting the same Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to tilmicosin. These hybridomas may be obtained by using as an immunization agent or...
37	6476199	Reagents for lysergic acid diethylamide immunoassay The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for...
38	6451543	Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention...
39	6423547	Non-covalent bioconjugates useful for diagnosis and therapy A composition comprising non-covalent carrier-hapten bioconjugates having the formula: HM-CM wherein HM is a hapten molecule whose molecular weight is generally, but not always, less than 1000...
40	6391590	Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity Streptavidin-metallothionein chimeric proteins with biological recognition specificity in which the streptavidin moiety provides high affinity biotin binding and the metallothionein moiety provides...
41	6383766	Reduced cortisol conjugates The present invention relates to compositions comprising novel reduced cortisol conjugates, methods for their preparation and use in immunoassays for cortisol. In another aspect, it relates to...
42	6358918	Preparation comprising thiol-group-containing proteins There is disclosed a stable, virus-safe, pharmaceutical preparation comprising thiol-group-containing proteins which are heat-treated and processed such that at least 40% of the thiol groups are...
43	6355803	Near infrared chemiluminescent acridinium compounds and uses thereof This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional...
44	6342585	Method of activating denatured protein The invention relates to a method for forming a mixed disulfide of recombinant proteins, by solubilizing with a denaturing agent in the presence of a disulphide component, and then adding a...
45	6328970	Rapamycin position 27 conjugates Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or...
46	6310180	Method for synthesis of proteins A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-α carboxyl groups. The method comprises ligating a first molecule to a second molecule...
47	6307029	Dye-labeled protein conjugate and method for preparing the same The present invention provides a dye-labeled protein conjugate in which a protein conjugate is labeled with a large number of dye molecules. In the dye-labeled protein conjugate, a protein...
48	6303757	Indirect polymerized and labelled antibody and method for manufacturing the same A high-sensitive indirect polymerized and labelled antibody is disclosed. The antibody facilitates detection of a low concentration of antigen as an analyte in a sample solution. The indirect...
49	6299881	Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical...
50	6291198	Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the...

Matches 1 - 50 out of 281

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