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4318846 |
Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
Diether symmetrically substituted fluoresceins are provided having at least one anionic group and a linking functionality. Depending upon the site of substitution, the compounds can be used as...
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4314993 |
Immunogenic E. coli ST enterotoxin derivatives and compositions containing them
E. coli heat stable (ST) enterotoxin derivatives are prepared by reaction of E. coli ST enterotoxin with crosslinking agents for proteins. The so-obtained crosslinked ST enterotoxins show...
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4310455 |
Antigen for early pregnancy test and contraceptive vaccine
Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the β-subunit of...
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4277460 |
Cortisol radioimmunoassay method and cortisol derivatives useful therefor
The cortisol compound of the formula (E) ##STR1## wherein R represents a hydroxy group, a tyrosine lower alkyl ester residue, a tyramine residue, a histamine residue, a 7-aminoheptanoyl-tyrosine...
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4275160 |
Imipramine derivatives and poly(amino acid) conjugates
Imipramine functionalized compounds are provided for conjugation to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of...
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4275000 |
Peptide macromolecular complexes
Macromolecular complexes which comprise a first and a second macromolecular moiety joined by a link derived from a linking agent having two or more reactive groups, one of these reactive groups...
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4272506 |
Purification of reagents by disulfide immobilization
A method is provided for preparing immunoassay reagents involving labeled members of specific binding pairs substantially enriched relative to contaminating labeled materials. The method involves...
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4268435 |
Chorionic gonadotropin derived antigen for early pregnancy test and contraceptive vaccine
Antisera suitable for detecting the presence of human chorionic gonadotropin in body fluids by immunoassay are prepared by administering to a host animal an antigen comprising the β-subunit of...
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4237044 |
Antibodies against creatinekinase-M8 and process for the production thereof
Antibodies against the M subunit of CK isoenzymes having a molecular weight between about 130,000 and 210,000, and inhibiting the enzymatic activity of the M subunit, optionally also in the...
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4220722 |
Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
Methods and compositions are provided for conjugating a wide variety of compounds, particularly polyfunctional compounds, having a mercapto group, either naturally present or synthetically...
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4218539 |
Enzyme conjugates and method of preparation and use
Novel enzyme conjugates useful in immunoassay methods are prepared with the use of a novel coupling reagent of N-succinimidyl (4-iodoacetyl) aminobenzoate by reacting the coupling reagent, firstly,...
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4215102 |
Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues
A cytochemical agent and method for the detection and identification of estrogen or progesterone receptor cells in carcinomas of the breast is described, involving an estrogen-protein-fluorochrome...
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4214048 |
Reagent suitable for enzyme immuno assay
A novel maleimidobenzoic acid N-hydroxysuccinimide ester of the formula: ##STR1## which is suitable as a binding agent for binding an enzyme and an antigen to give an enzyme-labeled antigen of the...
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4197286 |
Testosterone derivatives and assay method
An anti-testosterone serum is provided which is highly selective to the measurement of testosterone using radioimmunossay techniques in both male and female plasma without resorting to...
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4168263 |
Polypeptide derivatives
There is presented peptide derivatives comprising polypeptides to which are bound via its functional side-chains penicilloyl residues of the formula ##STR1## wherein R signifies 2-pentenyl,...
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4158705 |
Antigen-protein complex for blocking allergic reactions
A multivalent complex suitable for blocking allergic reactions comprising (1) at least one Timothy antigen D fragment having the antigenic determinant structure: ##STR1## wherein: G represents...
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4115539 |
Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives
Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form...
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4085202 |
Testosterone derivatives
Testosterone-15α or β-carboxyethyl thioether, 5α-, dihydrotestosterone-15α or β-carboxyethyl thioether related compounds and intermediates for preparation thereof. The compounds are conjugated...
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4081329 |
Preparation of carrier-bound macromolecular compounds
Carrier-bound macromolecular compounds, especially bioactive macromolecular compounds, are produced by reacting a macromolecular compound A with a coupling compound B containing at least one...
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4007089 |
Method for binding biologically active compounds
A method for binding biologically active compounds to carriers comprising reacting an asymmetric bifunctional linking compound having at least one phenyl azide moiety and at least one s-triazine...
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3917582 |
Isothiocyanate and thiourea derivatives of benzoyl ecgonine conjugated to polypeptides
Novel benzoyl ecgonine derivatives are provided having an isothiocyanate group for conjugation to polypeptides and proteins to provide derivatives as reagents in immunoassays or for preparation of...
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3884898 |
Normorphine derivatives bonded to proteins
Normorphine derivatives are provided for preparing compounds for use in immunoassays and for preparing antibodies to morphine. Carboxy functionalities or analogs thereof are bonded through an...
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3867365 |
Penicilloyl-polylysine conjugates having dextro-rotary optical activity, and methods for their preparation and use
The stereo-isomeric penicilloyl-polylysine conjugates having high optical dextro-rotations are useful for eliciting cutaneous responses in persons with penicillin hypersensitivity. The process for...
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3853832 |
SYNTHETIC HUMAN PITUITARY GROWTH HORMONE AND METHOD OF PRODUCING IT
Synthetic human pituitary growth hormone (HGH) is produced by attaching phenylalanine, the COOH terminal amino acid of HGH, to a solid resin support, and then coupling stepwise to the supported...
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3619371 |
PRODUCTION OF A POLYMERIC MATRIX HAVING A BIOLOGICALLY ACTIVE SUBSTANCE BOUND THERETO
A polymeric matrix having a biologically active substance chemically bound thereto, which comprises a polymer and a biologically active substance linked by groups of the formula: ##SPC1## Where Y...
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3453288 |
ELECTRON SPIN RESONANCE LABELS FOR BIOMOLECULES
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3639558 |
Title is not available
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3703352 |
Title is not available
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3825525 |
Title is not available
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3690834 |
Title is not available
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3652761 |
Title is not available
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