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7625859 |
HER-2 binding antagonists
There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an iso lated polypeptide having from...
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7625567 |
Induction of immune responses to isoaspartyl-modified antigens
The present invention is directed to a method of enhancing the immune response of a patient relative to the normal immune response, by administering isoaspartyl-modified proteins, peptides, or...
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7612171 |
DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7595292 |
Conjugated biological molecules and their preparation
Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking...
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7569358 |
Doxorubicin immunoassay
Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are...
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7566767 |
Synthetic peptides and methods of use for autoimmune disease therapies
The invention provides peptide compositions, and methods of making and using therapeutic compositions for treatment of a subject for an autoimmune or an inflammatory disease. The invention also...
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7563866 |
Modular antigen transporter molecules (MAT molecules) for modulating immune reactions, associated constructs, methods and uses
Modular antigen transporter molecules (MAT molecules), which are used as vaccines and for the treatment of allergies, include three modules: a translocation module which brings about transport of...
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7563864 |
Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7553494 |
WT1 fusion proteins
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7550561 |
p16INK4 polypeptides
The present invention relates to the discovery in eukaryotic cells, particularly human cells, a novel polypeptide of 16 kDa (hereinafter “p16 INK4 ” or “p16”) can function as an inhibitor...
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7547769 |
Immunomodulatory constructs and their uses
The invention relates to immunomodulators. In particular the invention relates to specific immunomodulators based on the superantigen SMEZ-2 and more particularly based on mutants of the...
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7538197 |
Use of neuregulin-β as an indicator and/or target
The invention relates, inter alia, to the use of neuregulin-β as a target in a screening method for active compounds, in particular for exerting an influence on changes in calcium concentration...
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7538182 |
Polypeptide and protein derivatives and process for their preparation
Protein and polypeptide derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the...
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7534866 |
Methods and compositions for generating bioactive assemblies of increased complexity and uses
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In...
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7527798 |
Composition and method for preventing or treating a virus infection
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.
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7527797 |
Vibrio cholerae 0139 conjugate vaccines
The invention pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These...
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7521202 |
Method and apparatus for the production of soluble MHC antigens and uses thereof
The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one...
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7501125 |
Vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete domain and is CD4+ T cell-independent
The present invention relates to a method of inducing a CD8 + CTL response to a molecule in an individual deficient in CD4 + T cells comprising administering to the individual an hsp or a portion...
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7488608 |
Reduction of non-specific binding in assays
Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding...
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7473535 |
Chemical reagents and methods for detection and quantification of proteins in complex mixtures
The invention provides a reagent comprising an affinity tag, a detectable moiety, a linker, an isotope tag and a reactive group. The invention also provides methods of using a reagent of the...
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7459281 |
Docetaxel immunoassay
Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in...
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RE40596 |
Rapamycin assay
Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for...
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7452982 |
Immunogenic complex
The invention relates to an immunogenic complex comprising at a least one glycoside and at least one lipid, integrated into an iscom complex or matrix, and at least one antigen which antigen is...
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7449549 |
PRO9822 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7429640 |
PRO6181 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7429458 |
Methods of using bioelastomers
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
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7423131 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7420043 |
Reagents for detecting efavirenz
The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled...
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7417115 |
PRO6027 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7408044 |
Carrier protein having an adjuvant effect
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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7405320 |
Therapeutic and diagnostic conjugates for use with multispecific antibodies
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or...
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7405279 |
Chimeric proteins for diagnosis and treatment of diabetes
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention...
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7402315 |
Hepatitis-C virus type 4, 5 and 6
The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide...
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7399838 |
Single chain class I major histo-compatibility complexes
A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant polypeptide comprises a chimeric polypeptide including an...
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7399645 |
Constrained cis-diol-borate bioconjugation system
The invention pertains to bioconjugation systems comprising sterically constrained cis-diols and borates.
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7390878 |
PRO6090 polypeptides
The present invention is directed to novel polypeptides having sequence similarity to trypsinogen and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and...
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7388073 |
PRO9835 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7388072 |
MAGE peptides presented by HLA class II molecules
The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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7385031 |
PRO6097 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7384915 |
Chimeric insulin-gad proteins for treating patients with type 1 diabetes or at risk of developing type 1 diabetes
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention...
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7381791 |
PRO9739 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7375183 |
Mesothelin, immunogenic peptides derived therefrom, and compositions comprising mesothelin, or immunogenic peptides thereof
This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form....
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7371829 |
Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites
The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as,...
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7361742 |
Methods and materials for treating inflammatory conditions
The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be...
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7355017 |
Blood group antigen fusion polypeptides and methods of use thereof
The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection.
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7354998 |
PRO7171 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7354589 |
Multiple antigenic agents and methods for using the same
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. The multiple antigenic agents of the invention contain at least one...
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7351435 |
Deglycosylated ricin toxin a-chain vaccine
The present invention relates to a vaccine comprising deglycosylated ricin toxin A-chain and method for making and using the composition.
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7348157 |
Immunoassay
A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two...
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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