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9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9040251 Biomolecule fixing board and method of manufacturing the same  
This invention provides a biomolecule modifying substrate comprising biomolecules selectively fixed to given regions thereon. The biomolecule modifying substrate comprises: a substrate at least...
9040478 Derivatisation of granulocyte colony-stimulating factor  
The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200...
9034661 Method for producing molecule immobilizing substrate, and molecule immobilizing substrate  
There is disclosed a method for producing a molecule immobilizing substrate, comprising at least the steps of: forming, on a substrate, a monomolecular film including hydroxyl groups, cyano...
9029516 Antibodies and molecules derived therefrom that bind to STEAP-1 proteins  
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and...
9029323 Neurturin conjugates for pharmaceutical use  
The present invention relates to neurturin protein products conjugated to polyols and to pharmaceutical compositions comprising neurturin conjugates as active ingredients, preferably PEGylated...
9029328 Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands  
The invention provides methods and compositions for reducing, preventing or reversing cardio toxicity side effects associated with certain therapeutic agents. The invention also provides methods...
9017655 Bispecific EGFR/IGFIR binding molecules  
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The...
9018360 Modified biotin-binding protein  
The present invention provides a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2 or its modified sequence and having a biotin-binding activity and...
9006182 Light activated composite tissue adhesives  
A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are...
9005600 Compounds useful for multi-level specific targeting of cancer cells  
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more...
8999661 Compositions for detecting cell death and methods of use thereof  
The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective...
8980276 Conjugates for the prevention or treatment of nicotine addiction  
The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III): wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain...
8969532 Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography  
The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which...
8962555 PlGF-1 in homodimeric form  
The present invention relates to a new homodimeric form of recombinant PlGF-1, to a process for its preparation and to compositions containing it.
8962804 Meditopes and meditope-binding antibodies and uses thereof  
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using,...
8957189 Multi-site modified SP1 polypeptides and uses thereof  
The present invention, in some embodiments thereof, relates to material science in general, and, more particularly, to sequence variants of Stable Protein 1 (SP1), to uses thereof, for binding of...
8933396 Analyte mass spectrometry quantitation using a universal reporter  
Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
8932829 Recombinant alpha-fetoprotein and compositions thereof  
Disclosed are pharmaceutical and synergistic compositions comprising human recombinant alpha-fetoprotein expressed in eucaryotic cells for preparation of therapeutic agents for use in oncology,...
8933203 Vault and vault-like carrier molecules  
A method of using vaults as carrier molecules to deliver one or more than one substance to an organism, or to a specific tissue or to specific cells, or to an environmental medium. A vault-like...
8933026 Derivatisation of erythropoietin (EPO)  
The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide...
8932828 Method for preparing recombinant granulocyte colony stimulating factor cysteine muteins  
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine...
8927232 Fusion protein capable of binding VEGF-A and TNF-alpha  
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide...
8916690 Growth-inhibited hydroxyapatite, process for its preparation and use  
The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in...
8907064 Modified human four helical bundle polypeptides and their uses  
Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
8906681 Reliable stabilization of N-linked polypeptide native states with enhanced aromatic sequons located in polypeptide tight turns  
A chimeric therapeutic polypeptide of a pre-existing therapeutic polypeptide is disclosed, as are a method of enhancing folded stabilization and a pharmaceutical composition of the glycosylated...
8906703 Surface-bound fluorinated esters for amine capture  
A method for immobilizing an amino-containing material to a substrate is described. The method involves providing a tethering compound with two reactive groups: a substrate reactive group and a...
8901277 Interferon alpha mutant and its polyethylene glycol derivative  
IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in...
RE45272 β-glucuronide-linker drug conjugates  
Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided.
8895706 Chromatography matrices including novel Staphylococcus aureus protein A based ligands  
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylooccus aureus Protein A (SpA), as well as...
8895281 Method for preparing a site-specific physiologically active polypeptide conjugate  
The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a...
8889147 DNA vaccine against multitypes of avian influenza viruses and influenza virus-like particles comprising adjuvant-fused M2 protein  
A DNA vaccine comprising hyperglycosylated mutant HA gene, which is derived from avian influenza virus, is provided. A DNA vaccine composition comprising: (a) the DNA vaccine; and (b) a booster is...
8889837 Purification of pegylated polypeptides  
The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both...
8883161 Fusion polypeptide against EB virus-induced tumor and colicin Ia mutant  
The present invention provides a fusion polypeptide against EB virus-induced tumor, which comprises an antibody or a mimetic antibody against EB virus and an ion channel forming colicin selected...
8865188 Methods and compositions for controlling assembly of viral proteins  
Provided herein are methods and compositions for controlling assembly of modified viral core proteins, for example, into a viral capsid or a nanocage. In some embodiments, the disclosed modified...
8859294 Method for binding a protein consisting of protein A or consisting of at least one domain of the A to E domains of the protein A to the substrate  
The object of the present invention is to provide a method for immobilizing the SpA protein on the surface of a substrate with high density without causing dimerization. The following method...
8841251 Method for making a homogenous vaccine composition comprising a conjugate of EGF and 64K for the treatment of tumors  
A vaccine composition for therapeutic use thereof on cancer patients includes a chemical conjugate of human recombining Epidermic Growth Factor (hrEGF) and a combining protein P64k for performing...
8841257 Inhibitors of STAT3 and uses thereof  
Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to...
8840879 Conjugates of hydroxyalkyl starch and a protein  
Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and...
8835144 Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate  
Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials....
8816050 Method of preparing glycopeptides  
A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coopled with a C-terminal...
8815794 Treatment of amyloidoses using myelin basic protein and fragments thereof  
In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the...
8816052 Mutant apoprotein of photoprotein with low calcium sensitivity  
Calcium-binding photoproteins showing the luminescence pattern with a slow decay of are desired. The invention provides a mutant apoprotein comprising an amino acid sequence wherein the 23rd to...
8815611 Surface for label independent detection and method thereof  
A functional group and spacer group modified polymer composition, articles incorporating the composition, and methods for label-independent-detection using the articles, as defined herein.
8809453 Branched polymers  
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core...
8809005 Conjugate and its use as a standard in an immunoassay  
A composition comprising a conjugate of an anti-idiotype antibody specifically binding to a CDR region of a parent antibody and method of using polyclonal human serum immunoglobulin of class E, G,...
8802824 Modified recombinant human endostatin and uses thereof  
Provided is a kind of modified recombinant human endostatin that has the structure of CH3O—(CH2CH2O)m—CH2CH2CH2—NαH-Endostar, wherein the average molecular weight of CH3O—(CH2CH2O)m—CH2CH2CH2— is...
8796216 Suppression of neuroendocrine diseases  
The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumor cell, preferably...
8796207 Derivatisation of erythropoietin (EPO)  
The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide...
8796431 Efficient production of peptides  
The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than...