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RE39355 |
Preparation of human IGF via recombinant DNA technology
Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.
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7119177 |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7119066 |
Modified ciliary neurotrophic factor (CNTF)
Modified ciliary neurotrophic factor, methods for production and methods of use, especially in the treatment of Huntington's disease, obesity, and gestational or adult onset diabetes.
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7118752 |
Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for...
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7115390 |
Connective tissue growth factor fragments and methods and uses thereof
The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF...
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RE39321 |
Supplemented and unsupplemented tissue sealants, methods of their production and use
This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds,...
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7112658 |
Orphanin FQ receptor polypeptides
The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the...
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7112341 |
Pulmonary administration of dry powder formulations for treating infertility
Provided are stabilized follicle stimulating protein (FSP) dry powder compositions for aerosolized delivery to the deep lung, methods of preparing and administering such compositions, and methods...
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7112659 |
OB fusion protein compositions and methods
The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or...
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7109030 |
Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other...
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7105182 |
Periodontal regeneration composition and method of using same
A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. All particles are sized to be less than...
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7105168 |
Method of improving ischemic muscle function by administering placental growth factor
The present invention relates to prevention and treatment of strokes and ischemic diseases and to post-ischemic therapeutic treatment. The invention furthermore relates to the use of a growth...
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7105480 |
Method of treatment and agents useful for same
The present invention relates generally to a method of modulating bone resorption and to agents useful for same. More particularly, the present invention provides for the use of leptin and its...
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7101539 |
Use of LP82 to treat hematopoietic disorders
The present invention relates to a method of using a mammalian gene sequence and polypeptides encoded thereby to treat mammalian hematopoietic disorders. More specifically the present invention...
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7101981 |
Bovine growth hormone recombinantly produced in E. coli
Recombinant materials have been obtained which permit the production of bovine growth hormone in E. coli.
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7101971 |
Erythropoietin analog-human serum albumin fusion
Erythropoietin analog-human serum albumin (EPOa-hSA) fusion protein and methods of making and using the fusion protein.
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7098183 |
Nucleotide and amino acid sequences of oocyte factors for altering ovarian follicular growth in vivo or in vitro
Aspects of the present invention relate to nucleotide and amino acid sequences of oocyte factors for altering ovarian follicular growth in vivo or in vitro. The present invention also concerns...
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7098318 |
Fusion protein having enhanced in vivo activity of erythropoietin
The present invention relates to a fusion protein having enhanced in vivo activity of erythropoietin wherein a carboxy terminal peptide fragment of thrombopoietin is fused with the carboxy terminal...
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7094884 |
Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them
The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble Aβ-chaperone complex and the advantageous use of such chaperone-Aβ...
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7094569 |
Hair follicle growth factor proteins
The present invention relates to novel hair follicle growth factor (HFGF) proteins, genes encoding HFGFs, methods for preparing HFGF proteins and therapeutic uses of HFGF proteins. The HFGF...
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7091326 |
Fusion protein having enhanced in vivo erythropoietin activity
Provided is a fusion protein comprising, at its carboxy terminal of human erythropoietin (EPO), a mutant having one to four amino acid substitutions in the carboxy terminal peptide (CTP) fragment...
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7090834 |
Vascular endothelial cell growth factor variants and uses thereof
The present invention provides VEGF variants having one or more amino acid mutations in the KDR and/or FLT-1 receptor binding domains in the native VEGF sequence and selective binding affinity for...
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7087411 |
Fusion protein capable of binding VEGF
Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF mini-traps are disclosed which are therapeutically useful for treating...
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7084262 |
Analysis and separation of platelet-derived growth factor proteins
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of...
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7081443 |
Chimeric comp-ang1 molecule
The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.
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7078514 |
Chicken growth hormone releasing hormone receptor
The present invention relates to chicken growth hormone releasing hormone (GHRH), its corresponding receptor, and nucleic acid sequences encoding these proteins. More particularly the present...
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7078487 |
PTH1R receptors
The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present...
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7078484 |
Melanin concentrating hormone receptors
Isolated polynucleotides encoding monkey Melanin Concentrating Hormone (MCH) Type 1 receptors and chimeric polypeptides are provided. Vectors and cells for recombinant expression of such MCH1R...
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RE39192 |
Supplemented and unsupplemented tissue sealants, methods of their production and use
This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation...
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7078382 |
Modulation of eNOS activity and therapeutic uses thereof
The present invention provides uses of VEGF or VEGF receptor agonists for the up-regulation of eNOS expression and activity. VEGF and VEGF receptor agonists are useful in the treatment of or...
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7074763 |
Stable formulations of nerve growth factor
Aqueous formulations of nerve growth factor suitable for lyophilization and subsequent reconstitution in which nerve growth factor is admixed with sugars and buffer are provided.
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7074762 |
Composition and method for improving function of embryonic kidney transplants
A method and composition for enhancing the development of metanephric tissue upon transplantation into an allogenic or xenogenic host are disclosed. Metanephric tissue is removed from an embryonic...
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7070946 |
Bone metabolism related protein and gene thereof
The present invention is directed to a novel method of detecting a function or activity of a polypeptide which is related to bone metabolism, in particular, differentiation (maturation) of...
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7071313 |
Methods of purifying authentic IGF from yeast hosts
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a...
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7071312 |
Epidermal differentiation factor
A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are...
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7067628 |
PRO788 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7067485 |
IGF-I composition and its use
A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I...
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7056886 |
GLP-2 formulations
The invention is directed to formulations of GLP-2 peptides and analogs thereof exhibiting superior stability following storage and/or exposure to elevated temperatures. The GLP-2 compositions...
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7056885 |
Fibroblast growth factor and nucleic acids encoding same
The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX...
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7052514 |
Methods and reagents for tissue engineering of cartilage in vitro
The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for...
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7048922 |
Stimulation of hematopoiesis by ex vivo activated immune cells
A protocol of activating and administering human blood cells so that bone marrow histology and/or blood cell counts of patients suffering from aplastic anemia approach normal. The protocol includes...
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7049403 |
Insulin/IGF/relaxin family polypeptides and DNAS thereof
The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a...
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7048934 |
Combined regulation of neural cell production
This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating...
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7045595 |
Hemopoietin receptor protein, NR12
A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence....
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7045318 |
Recombinant fusion proteins to growth hormone and serum albumin
The invention describes methods of producing fusion proteins of albumin and growth hormone and products obtained by the methods.
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7037894 |
Stabilized proteins
Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or...
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7038022 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of...
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7033610 |
Growth-promoting agent
The invention relates to pharmaceutical or veterinary compositions for the treatment of surface wounds; pharmaceutical or veterinary compositions for the treatment of gastrointestinal injuries,...
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7030218 |
Pseudo native chemical ligation
The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an...
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7026291 |
Epithelial cell specific growth factor, keratinocyte growth factor (KGF)
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of...
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