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6028058 |
Methods and compositions for regulating nuclear trafficking of proteins
Methods are provided to regulate the trafficking of nuclear proteins, including the high molecular weight forms of FGF-2, to the nucleus. A nuclear trafficking component, which is approximately 29...
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6025204 |
Diagnostic method for detection of placental-derived prostate growth factors
A diagnostic method is described for the detection of placental-derived growth factors which involves contacting a biological tissue or fluid sample with a labeled antibody which is specific to the...
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6025325 |
Pegylated obese (ob) protein compositions
Polyethylene and polypropylene protein conjugates which modulate body weight of animals and humans for the treatment, prevention and control of obesity and associated diseases or conditions, and...
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6025324 |
Pegylated obese (ob) protein compositions
Polyethylene and polypropylene protein conjugates which modulate body weight of ani is and humans for the treatment, prevention and control obesity and associated diseases or conditions, and the...
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6022711 |
Human growth hormone variants having enhanced affinity for human growth hormone receptor at site 1
Growth hormone participates in the regulation of normal growth and development processes. The binding affinity of growth hormone for its target receptors is dependent upon the interaction of site 1...
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6022858 |
Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
A pharmaceutical formulation comprising a growth hormone pretreated with zinc and optionally lysine or calcium ions shows a very high stability against deamidation, oxidation and cleavage of...
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6022554 |
Polymeric microporous film coated subcutaneous implant
This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a...
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6020311 |
GRF analogs with increased biological potency
The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone...
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6017885 |
IGF/IGFBP complex for promoting bone formation and for regulating bone remodeling
IGF and IGFBP are administered to stimulate new bone formation in subjects with bone loss due to bone marrow disorders, connective tissue disorders, drugs, pregnancy, lactation, chronic...
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6017886 |
Use of NDF peptide as growth factor for sensory epithelium
A non-naturally occurring peptide derived from EGF-like domains of NDF/heregulin protein isoforms is used to stimulate the proliferation of cells in the sensory epithelium of the inner ear.
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6017878 |
Nerve growth factor structural analogs and their uses
Cyclic compounds with a 3-dimensional structure that bind at least one neurotrophin receptor (NTR) under physiologic conditions in vitro or in vivo are new. Binding to NTR at least partially mimics...
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6018026 |
Biologically active dimerized and multimerized polypeptide fusions
Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers...
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6013773 |
Pharmaceutical preparation containing human growth hormone
A stable pharmaceutical preparation containing a human growth hormone having a molecular weight of about 20,000, or a derivative thereof, can be formulated by adding a water soluble heterocyclic...
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6013624 |
Method for inducing the proliferation and migration of endothelial cells using scatter factor
The present invention provides a novel method of inducing proliferation and migration of endothelial cells in a subject comprising administering an amount of scatter factor effective to induce the...
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6011009 |
Method for determining angiogenesis using scatter factor
The present invention provides a novel method of determining the presence of angiogenesis in a subject comprising detecting the presence of scatter factor in the subject.
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6011002 |
Circularly permuted ligands and circularly permuted chimeric molecules
The present invention provides for circularly permuted ligands which possess specificity and binding affinity comparable to or greater than the specificity and binding affinity of the original...
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6011004 |
Use of growth factors to treat drug-inducted neuropathy
This invention relates to the use of neuronotrophic factors, such as nerve growth factor (NGF), ciliary derived neuronotrophic factor (CNTF), brain derived neuronotrophic factor (BDNF),...
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6010999 |
Stabilization of fibroblast growth factors by modification of cysteine residues
The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing...
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6008328 |
Method for purifying keratinocyte growth factors
The present invention concerns the purification of keratinocyte growth factors.
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6007981 |
Polynucleotide encoding a receptor for a Bacillus thuringiensis toxin and methods of use
The cDNA that encodes a glycoprotein receptor from the tobacco hornworm which binds a Bacillus thuringiensis toxin has been obtained and sequenced. The availability of this cDNA permits the...
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6004937 |
Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
Methods are provided for the modulation of the effects of GDF-8 and BMP-11, particularly on neural and muscular disorders administration of follistatin for treating neural, muscle, disorders which...
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6005081 |
Purification of recombinant human neurotrophins
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6004929 |
Biologically active PDGF A-chain homodimers
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains...
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6001963 |
Ligands of the neuropeptide receptor HFGAN72
Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or...
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5997868 |
Inhibition of scatter factor for blocking angiogenesis
The present invention provides a novel method of inhibiting angiogenesis in a subject by blocking the ability of endogenous scatter factor to promote angiogenesis in the subject. The endogenous...
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5998588 |
Interactive molecular conjugates
The combination of the capabilities of stimuli-responsive components such as polymers and interactive molecules to form site-specific conjugates which are useful in a variety of assays,...
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5998170 |
Polynucleotides encoding hepatocyte-specific members of the FGF family
Nucleic acid molecules are described which are useful in vectors, transformed or transfected host cells, and methods for the recombinant expression of hepatocyte growth-specific polypeptide members...
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5994302 |
Human vascular IBP-like growth factor
A human Vascular IBP-like growth factor polypeptide (VIGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also...
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5994148 |
Method of predicting and enhancing success of IVF/ET pregnancy
A method of determining the probability of an in vitro fertilization (IVF) or embryo transfer (ET) method being successful is disclosed. Relaxin can be measured directly in the serum or indirectly...
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5994301 |
Corpuscles of stannius protein, stanniocalcin
The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant...
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5990084 |
Compounds with growth hormone releasing properties
The present invention related to truncated GHRs of the general formula I K-(M) x -A-B-(C) w -D-E-(F) z -G-(N) y -L (I) which have the ability to stimulate release of endogenous growth hormone.
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5989584 |
CCK antibodies used to improve feed efficiency
A method of increasing food efficiency in both avians and mammals by using antibodies to gut peptides such as choleocystokinin to elicit a biological response which decreases gastrointestinal...
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5990085 |
Inhibin-HBc fusion protein
A fusion protein formed of an antigenic inhibin peptide inserted into hepatitis B capsid protein is expressed from a chimeric gene forming an effective immunogen which induces anti-inhibin...
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5990078 |
Means of increasing estrogen receptor levels in neural tissue
This invention provides a method of increasing the level of estrogen receptors in the neural tissue of a subject which comprises administering to the subject estrogen in an amount effective to...
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5985583 |
Cloning and expression of gonadotropin-releasing hormone receptor
The present invention relates to the GnRH-R genes and proteins. The DNA sequence disclosed herein may be engineered into expression systems designed for the production of GnRH-R and/or cell lines...
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5985261 |
Use of thioredoxin-like molecules for induction of MnSOD to treat oxidative damage
A method to increase cellular MnSOD production in an animal to treat oxidative damage by administering a protein having a thioredoxin active-site in reduced state. A composition and a method to...
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5986069 |
Human haemopoietic maturation factor polypeptides
Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides...
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5981165 |
In vitro induction of dopaminergic cells
A culture method for inducing the expression of tyrosine hydroxylase in neural cells is provided. Mammalian CNS neural cells are cultured in the presence of a fibroblast growth factor and at least...
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5981215 |
Human criptin growth factor
A human Criptin Growth Factor polypeptide (CGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are...
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5977310 |
Peg-modified HGF
This invention relates to a PEG-modified HGF (Hepatocyte Growth Factor), namely HGF modified by polyethylene glycol. The PEG-modified HGF of the invention has a prolonged clearance in vivo,...
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5977069 |
Pharmaceutical formulation
A pharmaceutical preparation comprising a growth hormone and asparagine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds....
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5977307 |
Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a...
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5977068 |
Stabilized growth hormone compositions
The present invention relates to compositions of growth hormones and preservatives which do not interfere with the activity of the growth hormone.
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5973114 |
Isolation and characterization of the growth hormone releasing hormone receptor
Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which...
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5972889 |
Method for inhibiting the proliferation of epithelial lens cells and implantable lens therefor
A conjugate of a polypeptide reactive with a fibroblast growth factor receptor and a cytotoxic agent is used for inhibiting the proliferation of epithelial lens cells, especially following...
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5969099 |
Growth factor analogs
A peptide having growth factor type activity (mitogenic and agonist/antagonist for the EGF receptor) which is a TGF-α analog but contains a bicyclic Pro analog (for instance...
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5968778 |
PDGF-AB, preparation process and pharmaceuticals containing them
The invention relates to a process for the preparation of PDGF-A and to biologically active PDGF-AA and PDGF-AB.
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5968501 |
Hepatocyte growth factor--induced proliferation and differentiation of erythroid cells
Hepatocyte growth factor stimulates proliferation and differentiation of hematopoietic cells, most preferably burst-forming unit-erythroid cells. The hepatocyte growth factor may be obtained from...
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5965523 |
Method for enhancing transplanted tissue using scatter factor
The present invention provides a novel method of enhancing transplanted tissue in a subject comprising administering an amount of scatter factor effective to promote angiogenesis and enhance tissue...
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5965520 |
Therapeutic treatment of rheumatoid arthritis and polymyalgia rheumatica
Disclosed is a therapeutic regime for treating patients with rheumatoid arthritis (RA) Supplemental growth hormone is periodically administered to raise insulin-like growth factor 1 (IGF-1) levels,...
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