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6551996 |
Super-active porcine growth hormone releasing hormone analog
Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH...
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6551991 |
Recombinant proteins derived from HGF and MSP
Recombinant proteins deriving from recombination of structural domains deriving from the α subunits of HGF and/or MSP growth factors. The recombinant proteins of the present invention have...
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6541217 |
Hematopoietic stem cell growth factor (SCGF)
The present invention provides a novel polypeptide possessing growth activities on hematopoietic stem cells, a gene encoding the polypeptide and an antibody reacting specifically with the...
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6541447 |
Wound healing composition and method for use thereof
A composition for wound healing and hair growth is disclosed. The composition comprises at least 5.0% by weight of ovalbumin, about 1.0% phenoxyethanol, about 0.5% carbomer, and about 0.3%...
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6537965 |
Amino-terminal modified parathyroid hormone (PTH) analogs
Disclosed are novel parathyroid hormone (PTH) peptide derivatives. In particular, the invention relates to PTH derivatives having amino acid substitutions that confer PTH-1/PTH-2 receptor agonist...
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6534634 |
Diagnostic agent and method to determine pregnancy in ruminants
The present invention relates to diagnosis aids and processes for detecting pregnancy in ruminants based on the relaxin-like factor detectable in ruminants. Antibodies against the relaxin-like...
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6531134 |
Mammalian milk growth factor
A mammalian milk growth factor (MMGF) having the following amino acid sequence or substantially homologous sequence:...
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6528050 |
Growth factor homolog zvegf3
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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6525023 |
Vascular smooth muscle cell growth factor
The present invention provides a novel vascular smooth muscle cell growth factor, a DNA encoding VSGF, a vector containing the DNA, a method for producing a transformant obtained by transformation...
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6521591 |
Pharmaceutical composition for muscular anabolism
A pharmaceutical composition suitable for enhancing muscular anabolism contains, per daily dose, at least 5 mg of anabolic initiators comprising anabolic growth factors, at least 0.12 g of protein...
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6518238 |
Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3
Methods are provided for treating or alleviating the symptoms of subjects with psychological disorders, metabolic disorders, chronic stress-related disorders, sleep disorders, conditions associated...
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6518236 |
FGF homologs
The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for...
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6514481 |
Magnetic nanoparticles for selective therapy
The present invention provides novel nanosized particles termed as “nanoclinics” for therapeutic and/or diagnostic use. The particles have a core made of a therapeutic or diagnostic material...
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6515105 |
Neuropilin/growth factor complexes and uses thereof
Complexes of a protein selected from the group consisting of VEGF-B 167 , VEGF-C, VEGF-D and processed VEGF-B 186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain...
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6509443 |
IGF-I point variants
IGF-I and insulin variants are provided that selectively bind to IGFBP-1 or IGFBP-3. These agonist variants are useful, for example, to improve the half-lives of IGF-I and insulin, respectively.
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6509318 |
TGF-B inhibitors and methods
A family of small peptides have been found to be inhibitory to TGF-β activity, and preferably have the primary structure of Formula I: AA 1 -AA 2 -AA 3 -Pro-D-Glu-Ala FORMULA I wherein AA 1 is...
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6506727 |
Nerve regeneration
It has been found that the growth factor PDGF, when used in combination with another growth factor such as IGF-I, acts synergistically with the other factor to promote neuronal regeneration.
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6506884 |
Variant of vascular endothelial growth factor
The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and...
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6504005 |
Long-acting drugs and pharmaceutical compositions comprising them
Disclosed are conjugates of a polypeptide or oligopeptide with a low molecular weight lipophilic compound, the peptide and lipophilic group being covalently linked to one another either directly or...
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6500925 |
Human thyroid protein ZSIG45
The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used...
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6498144 |
Use of scatter factor to enhance angiogenesis
This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.
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6492129 |
Fragments of connective tissue growth factor that induce extracellular matrix synthesis, collagen synthesis and/or myofibroblast differentiation
The present invention is directed to CTGF fragments comprising at least exon 2 or exon 3 of CTGF and having the ability to induce extracellular matrix synthesis, in particular, collagen synthesis...
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6489294 |
Truncated insulin-like growth factor binding protein-5 having mitogenic activity
Purified C-terminally truncated insulin-like growth factor binding protein-5 (IGFBP-5) compounds are described. The compounds are mitogenic and bind to insulin-like growth factors (IGFs) with...
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RE37919 |
Recombinant DNA method for production of parathyroid hormone
A recombinant DNA molecule coding for human parathyroid hormone operably linked to an inducible bacterial promoter, a leader growth hormone sequence, and a selective enzymatic cleavage site,...
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6485942 |
Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production
Described herein are vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminus heparin binding domain. The variants exhibit reduced clearance rates for systemic...
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6482408 |
Fibroblast growth factor 15 antibodies
The present invention relates to antibodies directed to the human protein called Fibroblast Growth Factor 15.
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6479643 |
Single chain analogs of the TGF-β superfamily (morphons)
Disclosed are a family of single-chain polypeptide constructs designed to agonize or mimic members of the TGF-β superfamily by binding to a cell surface receptor complementary to the superfamily...
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6479642 |
Cortistatin: neuropeptides
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with...
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6468543 |
Methods for promoting growth of bone using ZVEGF4
Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective...
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6465259 |
Non radioactive receptor assay suitable for quantitative and qualitative analysis of trace amounts of receptor binding analyte
A method for quantitatively and/or qualitatively assaying an analyte in a sample, wherein the analyte is a receptor binding compound, has low detection limits equivalent to those of radioreceptor...
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6464983 |
Methods and uses of connective tissue growth factor for differentiation of mesenchymal stem cells
The present invention relates to novel methods and compositions related to the administration of connective tissue growth factor, alone or in combination with other growth factors, compositions or...
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6458764 |
GRF analogs with increased biological potency
The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone...
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6458541 |
BDNF polymorphism and association with bipolar disorder
Methods for diagnosing and treating neuropsychiatric disorders, especially bipolar disorder, and to methods for identifying compounds for use in the diagnosis and treatment of neuropsychiatric...
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6455049 |
Biologically active and particularly peptide molecules having a potentiating effect on growth hormone biological activity
A peptide construct including all or part of the sequence between positions 104 and 113 of growth hormone GH, or a homologous sequence cross-reactive therewith, is disclosed. The peptide fragment...
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6455283 |
Nucleic acids encoding vascular endothelial cell growth factor-E (VEGF-E)
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor...
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6451312 |
VEGF-gelonin for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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RE37850 |
Recombinant human endothelial cell growth factor
Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering...
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6451347 |
Method for purifying human growth hormone
A method of purifying human growth hormone (hGH) from deamidated hGH, oxidized hGH or both. The method comprises the steps of forming a metal cation complexed-hGH composition enriched in native hGH...
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6448381 |
DNA encoding heparin-binding growth factor
A novel heparin-binding growth factor of 18.9 kDa mol. wt. is disclosed which is purified from bovine uterus and human placenta and has a unique 25 N-terminal amino acid sequence as follows: ...
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6447783 |
Compositions comprising FGF9 and use thereof for stimulating cartilage and bone repair
The invention provides murine and chicken FGF9 polypeptides and recombinant DNA sequences encoding them. Also included in the invention are compositions containing FGF9 or an agent that binds to...
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6448382 |
Analysis and separation of platelet-derived growth factor proteins
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of...
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6444793 |
Hydrophobically-modified hedgehog protein compositions and methods
Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or...
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6440954 |
Inhibition of vascular smooth muscle cell proliferation
Methods of treating a mammal having a condition characterized by vascular smooth muscle cell proliferation, where the mammal is treated with progesterone or an agonist thereof. Also disclosed are...
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6436389 |
Stimulation of cell proliferation by glycosylated cystatin C
The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a co-factor to stimulate and/or potentiate the...
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6436668 |
Process for the expression and production of the recombinant growth factor protein (BEGF) derived from BEAN 58058 virus (BEV)
The present invention describes recombinant growth factor (BEGF) protein isolated from the virus BeAn58058, their corresponding encoding recombinant DNA molecule and the process of production of...
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6437101 |
Methods for protein purification using aqueous two-phase extraction
Methods are provided in this invention for the isolation of human growth hormone, growth hormone antagonist, or a homologue of either, from a biological source. The methods of the invention use...
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6432643 |
Method of determining Alzheimer's disease risk using apolipoprotein E4 genotype analysis in combination with decreased estrogen levels
A method of screening a subject for risk of developing Alzheimer's disease is carried out by determining the presence of at least one ApoE4 allele in a subject, and determining the presence or...
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6432406 |
Method for reducing angiogenesis by administration of a scatter factor inhibitor
This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.
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6429195 |
Aqueous prolonged release formulation
Prolonged parenteral release into the circulatory system of a cow of a bioactive growth hormone releasing factor at desirably effective levels can be achieved using novel compositions in which the...
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6428781 |
Composition of an endogenous insulin-like growth factor-II derivative
The effects of endogenous insulin-like growth factor can be appreciated by administering compounds capable of increasing free IGF in living bodies. Compounds are described which can elevate the...
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