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7638608 |
Assay for the separation and quantification of hemagglutinin antigens
The present invention relates to novel methods for separating hemagglutinin (HA) antigens, comprising the steps of applying a reduced and derivatized antigen preparation comprising solubilized HA...
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7619072 |
Purification method for recombinant glucose binding protein
The present invention relates to a method for purifying a recombinant glucose binding protein, in particular the lectin Concanavalin A (Con A). The method specifically utilizes a buffer in which...
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7550159 |
Orally ingestible preparation of mistletoe lectins and method
An orally ingestible preparation consisting essentially of Mistletoe lectin I (ML-I), Mistletoe lectin II (ML-II), and Mistletoe lectin III (ML-III), which specifically excludes the nausea-inducing...
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7452543 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
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7332470 |
Methods and compositions for treating ocular disease
The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease.
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7329739 |
Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells
It is intended to provide lectins and a lectin library comprising these lectins which are useful in recognizing differences in carbohydrates on cell surface (for example, sugar chains and cell...
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7306821 |
Process for producing a high solubility, low viscosity, isoflavone-enriched soy protein isolate and the products thereof
A soy protein isolate that has increased amounts of isoflavones and saponins and a high Nitrogen Solubility Index (“NSI”) is produced by a process that involves ultrafiltration and the...
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7282481 |
Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same
A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active...
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7052702 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
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7049414 |
Isolation of lectins
The invention relates to a process for isolating a lectin composition, in particular comprising the mannose-binding lectin (MBL), suitable for using recombinantly produced lectins as starting...
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7041782 |
Lectin ss3939 DNA and polypeptides
The invention is directed to purified and isolated novel ss3939 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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7015313 |
Lectin protein prepared from Korean marine crab Philyra pisum, process for preparing the same and the use thereof
The present invention relates to a lectin protein prepared from Korean marine crab Philyra pisum , process for preparing the same and the use thereof. This protein can be used as a diagnosing...
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6992178 |
Agent imparting resistance to external stimuli
The invention provides an agent for conferring resistance comprising a lectin as an effective component, which are able to confer resistance against external stimuli to animal cells, particularly...
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6987022 |
Leukemic cell-adsorbing material containing lectin protein from Dolichos beans or soybeans
An efficient method for therapeutic treatment of a leukemic patient is disclosed in which the patient's body fluid under external circulation is brought into direct contact with an adsorbent...
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6979727 |
Recombinant conglutinin and producing method thereof
A recombinant conglutinin which contains a collagen region consisting of six amino acids containing two amino acid sequences Gly-Xaa-Xaa (SEQ ID NO:3, wherein Xaa stands for a protein-constituting...
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6960652 |
Compositions and methods for modifying toxic effects of proteinaceous compounds
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines...
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6919210 |
Method for identifying autoimmune disease, method for detecting anti-Reg protein autoantibody and diagnostics for autoimmune disease
A method for judging an autoimmune disease by detecting the existence of an anti-Reg protein autoantibody in a specimen; and a method for judging insulin-dependent or non-insulin-dependent diabetes...
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6846913 |
Crude extract from Viscum album coloratum, and proteins and lectins isolated therefrom
Disclosed is an extract from Korean mistletoe KM-110, which is of immunity enhancement and activity against tumor metastasis and can be used as an adjuvant material for vaccines applicable for the...
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6846649 |
Recombinant human mannan-binding lectin
The present invention relates to methods of producing and/or isolating MBL compositions. In particular the invention relates to methods of producing and/or isolating novel recombinant human MBL...
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6787639 |
Collectin
A gene encoding a novel collectin protein which is expected to exhibit an antibacterial activity, an antiviral activity, etc. particularly in the human body, and its amino acid sequence.
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6774220 |
Compounds having lectinic properties and their biological applications
The invention relates to nucleotide sequences capable of coding for polypeptides having lectinic properties and to corresponding polypeptides of the sarcolectin type and their uses in therapeutics....
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6770758 |
Polysaccharide separation method
A method for the separation of polysaccharides. The method comprises conjugating a ligand to a thermo-sensitive polymer to form a conjugate, wherein the ligand specifically recognizes a...
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6605699 |
Galectin-11 polypeptides
The present invention relates to galectin 11 proteins which are members of the galectin superfamily. In particular, the present invention relates to full-length polypeptides, fragments, and...
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6514716 |
Detection of the end-position sialic acid groups of the human transferrin molecule
The subject matter of this invention is a method of determining terminal sialic acid residues in human transferrin according to a sandwich principle, which is characterized in that the sample fluid...
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6492499 |
Human pancreatitis-associated protein
The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells,...
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6407068 |
Method of treating humans with diseases characterized by high secretion of cytokines from macrophage cells
A method of treating an individual who is suffering from human immunodeficiency virus infection is disclosed. Methods of treating a human suffering from a disease characterized by high secretion of...
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6306613 |
Modulators of leaderless protein export and methods for identifying and using the same
Methods of modulating the export of a leaderless protein from a cell by contacting the cell with a compound that alters the binding of the leaderless protein and a transport molecule are provided....
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6281197 |
Cardiac glycosides and their aglycone derivatives treat complications of diabetes
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
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6156519 |
(➝)-β- d-glucan binding protein, an antibody recognizing the protein and use thereof
A (1➝3)-β-D-glucan binding protein obtainable by affinity chromatography or gel filtration of an extract of horseshoe crab amoebocytes and having a molecular weight of about 580 kDa, as...
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6153195 |
Method of delivering drugs to cells specific for an HL-60 lectin
Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment...
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6117836 |
Glycosylation-mediated inhibition of factor X
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6107283 |
Cardiac glycosides inhibit proliferation of cells bearing FGF receptors
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
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6083706 |
Inhibitors of leaderless protein export
Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are...
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6084072 |
Purified lectin and methods of use
Amaranthin, a new lectin isolated from the seeds of Amaranthus caudatus, is purified and characterized. Amaranthin, designated ACA (Amaranthus caudatus agglutinin), has a high affinity for the...
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6084073 |
Recombinant ricin toxin
DNA sequences encoding full length precursor proteins, which proteins contain both A and B portions of two ricin isotoxins and ricin agglutinin, as well as the linker regions have been determined....
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6071885 |
Treatment of FGF-mediated conditions by administration of a cardiac glycoside or aglycone derivative thereof
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include...
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6054315 |
Method for making activated neutrophils recognizable to macrophages
Methods for treating and modulating an inflammatory response using compositions containing a primarily monomeric or primarily dimeric form of galectin-1. The dimeric form stimulates apoptosis of...
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5981493 |
Method of treating humans infected with human immunodeficiency virus
A method of treating an individual who is suffering from human immunodeficiency virus infection is disclosed. The method comprises administering to a human who is suffering from human...
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5965712 |
LZ-CD23 chimera for inhibition of IgE-mediated allergic disease
CD23 is a low affinity receptor for IgE. The extracellular part of this molecule has been linked to a modified leucine zipper. This results in a trimeric configuration, since the stalk region of...
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5945514 |
Antiviral raw materials
The present invention relates to an antiviral raw material having mannose-binding type lectin bound, through a hydrophilic high-molecular chain, to a base material composed of a hydrophobic...
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5929036 |
Ligand or GMP-140 selectin and methods of use thereof
Fucosylated sialyated lactosaminoglycan structures that bind to GMP-140 have been discovered. The structure is created by expression of α(1,3) fucosyltransferases capable of modifying acceptors...
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5895811 |
Artificial positive controls derived from bifunctional conjugates
The invention relates to an artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.
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5880091 |
Glycoprotein ligand for P-selectin and methods of use thereof
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of 3 ...
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5858368 |
Vaccine comprising a baculovirus produced influenza hemagglutinin protein fused to a second protein
A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of...
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5760177 |
Lipopolysaccharide binding protein and process for producing the same
The invention provides a lipopolysaccharide (LPS) binding protein isolated from horseshoe crab. The LPS binding protein is isolated by (i) extracting the hemocyte membrane fraction of horseshoe...
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5710257 |
Method of causing selective immunosuppression using HL-60-related lectins
Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment...
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5693760 |
Method of causing selective immunosuppression using HL-60 related lectins
Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment...
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5644035 |
Method for purifying secreted Mac-2-binding glycoprotein
A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approximately 25S and having the ability to selectively bind human Mac-2 or...
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5607920 |
Concanavalin a binding proteins and a 76kD chondrocyte membrane protein (CMP) from chondrocytes and methods for obtaining same
The invention is directed to purified and isolated concanavalin A-binding proteins from chondrocytes that are not present in dedifferentiated cells from chondrocytes. The invention is also directed...
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5587460 |
14-beta-gal mammalian lectins
Human HL-60 lectin having an amino acid sequence different from other known animal lectins is disclosed. This is one member of a class of mammalian lectins extractable in lactose or detergent and...
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