|
Match
|
Document |
Document Title |
|
|
7618941 |
Treating degenerative joint disorders with tribonectins
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
|
|
|
7598354 |
Campylobacter glycans and glycopeptides
Multiple strains and species of Campylobacter share a common glycan moiety which is present in a plurality of surface-exposed glycoproteins. This glycan has the formula: GalNAc-a1,...
|
|
|
7592423 |
Globular adiponectin variants
An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does...
|
|
|
7585943 |
Compositions and methods for fusion protein separation
The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.
|
|
|
7575908 |
Immobilization method for producing active α1-acid glycoprotein
A method and kit for immobilization of a glycoprotein. The method may include activating an affinity support. The affinity support may be activated by reacting the affinity support with a compound...
|
|
|
7569351 |
P53 dependent apoptosis-associated gene and protein
A novel apoptosis-associated gene p53AIPI is isolated by screening for a gene the expression of which is induced by p53. Since the protein encoded by this gene has an activity of inducing...
|
|
|
7557188 |
Methods of treating blood coagulation disorders using a pharmaceutical preparation comprising vWF propeptide
Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWF propeptide as well as a method for producing such a preparation.
|
|
|
7553939 |
T cell regulatory genes and methods of use thereof
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and...
|
|
|
7550561 |
p16INK4 polypeptides
The present invention relates to the discovery in eukaryotic cells, particularly human cells, a novel polypeptide of 16 kDa (hereinafter “p16 INK4 ” or “p16”) can function as an inhibitor...
|
|
|
7550159 |
Orally ingestible preparation of mistletoe lectins and method
An orally ingestible preparation consisting essentially of Mistletoe lectin I (ML-I), Mistletoe lectin II (ML-II), and Mistletoe lectin III (ML-III), which specifically excludes the nausea-inducing...
|
|
|
7524814 |
Lactoferrin compositions and methods of wound treatment
The present invention relates to lactoferrin compositions and methods of using the compositions to treat wounds. The compositions can be administered alone or in combination with other standard...
|
|
|
7514240 |
EGR-EGFR complex
The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating...
|
|
|
7507556 |
Nucleic acids encoding rat hyaluronan receptor for endocytosis
A purified nucleic acid segment encoding a functionally active hyaluronan receptor for endocytosis (HARE) or an active peptide fragment thereof, and methods for producing functionally active HARE...
|
|
|
7499847 |
Crystalline VAP-1 and uses thereof
The present invention relates to crystalline vascular adhesion protein-1 (VAP-1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or...
|
|
|
7494975 |
Anti-HIV composition, production method thereof and medicament
The present invention relates to an anti-HIV composition and to the method for producing it. The composition of the present invention comprises a polyanion and a molecule capable of inducing the...
|
|
|
7485429 |
Integrin heterodimer and an alpha subunit thereof
A recombinant or isolated integrin heterodimer comprising a novel subunit α11 in association with a subunit β is described. The integrin or the subunit α11 can be used as marker or target of all...
|
|
|
7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
|
|
|
7452859 |
Human bikunin
The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental...
|
|
|
7449292 |
Methods for predicting relative efficacy of a beta blocker therapy based on a B1-adrenergic receptor polymorphism
Methods and compositions for the detection, diagnosis, and prevention of cardiac conditions are provided. Polymorphisms of β 1 -adrenergic receptor are provided. The Gly389 β 1 -adrenergic...
|
|
|
7438915 |
Immunopotentiating effect of a Fomitella fraxinea-derived lectin on chicken immunity and resistance to coccidiosis
This study reports a novel immunopotentiating effect of a lectin (FFrL) extracted from the mushroom Fomitella fraxinea on poultry cell-mediated immunity and poultry coccidiosis. We describe the...
|
|
|
7431921 |
Interferon beta-like molecules
The invention relates to a conjugate exhibiting interferon β (IFNB) activity and comprising at least one first non-polypeptide moiety covalently attached to an IFNB polypeptide, the amino acid...
|
|
|
7427671 |
Compositions of alpha platelet derived growth factor receptor nucleic acid and protein and method of making
A DNA sequence which encodes a human type α platelet derived growth factor receptor protein which preferentially binds to the AA homodimer and AB heterodimer forms of platelet derived growth...
|
|
|
7423130 |
PRO1158 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7405198 |
Glycopegylated erythropoietin
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the...
|
|
|
7402562 |
Composition for stabilizing corneal tissue during or after orthokeratology lens wear
An orthokeratological procedure is provided that prevents or retards relaxation of corneal tissue back to the original anterior curvature of the cornea. The procedure comprises applying a...
|
|
|
7399838 |
Single chain class I major histo-compatibility complexes
A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant polypeptide comprises a chimeric polypeptide including an...
|
|
|
7396529 |
Compositions and methods for regulating receptor clustering
The invention relates to isolated complexes comprising one or more galectin associated with Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan...
|
|
|
7381805 |
Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino...
|
|
|
7381804 |
G-CSF analog compositions and methods
The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions...
|
|
|
7381411 |
Aglyco products and methods of use
Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which...
|
|
|
7378506 |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs)...
|
|
|
7378392 |
Bone and cartilage inductive proteins
Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and...
|
|
|
7355017 |
Blood group antigen fusion polypeptides and methods of use thereof
The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection.
|
|
|
7354594 |
Merozoite surface protein 1 lacking glycosylation sites
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
|
|
|
7354588 |
Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV
The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as...
|
|
|
7351435 |
Deglycosylated ricin toxin a-chain vaccine
The present invention relates to a vaccine comprising deglycosylated ricin toxin A-chain and method for making and using the composition.
|
|
|
7335733 |
Tissue cement proteins from Rhipicephalus appendiculatus
The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful...
|
|
|
7329643 |
Inhibition of HMGB1 release by fetuin
Methods of inhibiting HMGB1 release by a mammalian cell are provided. The methods comprise treating the cell with sufficient fetuin to inhibit HMGB1 release. Methods of inhibiting an inflammatory...
|
|
|
7326775 |
Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation...
|
|
|
7323443 |
Lactoferrin in the reduction of pain
The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone...
|
|
|
7312198 |
Protein compositions for promoting wound healing and skin regeneration
Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell...
|
|
|
7306791 |
Agent for preventing and/or treating multiple organ failure
The present invention provides methods of preventing and/or treating multiple organ failure comprising the step of administering a therapeutically effective amount of agent comprising tumor...
|
|
|
7282481 |
Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same
A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active...
|
|
|
7268219 |
Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means
A complex comprising an HLA Class 1 molecule and attaching means for selectively attaching the HLA class 1 molecule to a target cell is disclosed, and a method is provided for producing or...
|
|
|
7262177 |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use
A conjugate of formula A-L-P, in which:
A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise...
|
|
|
7262166 |
Chemically modified novel erythropoietin stimulating protein compositions and methods
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
|
|
|
7262058 |
Method for determining lipid associated sialoprotein in body fluids
The amount of lipid associated sialoprotein (LSP) in body fluids such as cerebrospinal fluid, peritoneal fluid, pleural fluid, bronchial washings, saliva and sputum samples, may be determined by a...
|
|
|
7255854 |
Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases
Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly...
|
|
|
7241735 |
Pharmacologically active polypeptide glycoconjugates
The invention relates to glycopeptidic glycoconjugates, in which the polysaccharide is obtained from Candida utilis cells and the peptides are obtained from Ricinus communis seeds. The...
|
|
|
7235525 |
Agent for treatment of metabolic bone disease
An agent for treatment of metabolic bone disease, which contains EPO as an active ingredient, or a method for treating a patient with metabolic bone disease, which comprises EPO, is provided....
|