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8183347 |
Anti-TAT226 antibodies and immunoconjugates
Anti-TAT226 antibodies and immunoconjugates thereof are provided. Methods of using anti-TAT226 antibodies and immunoconjugates thereof are provided.
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8163888 |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected...
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8163889 |
Physiologically active polypeptide conjugate having prolonged in vivo half-life
A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is...
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8153768 |
Calicheamicin derivative-carrier conjugates
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate...
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8124364 |
Biotin derivatives
A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or...
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8110665 |
Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition...
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8088387 |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected...
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8067006 |
Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in...
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8057798 |
Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells
The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached...
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8039273 |
β-glucuronide-linker drug conjugates
Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided.
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7999083 |
Immunoconjugates with an intracellularly-cleavable linkage
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and...
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7989598 |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected...
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7985843 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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7977465 |
Peptidyl prodrugs and linkers and stabilizers useful therefor
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming...
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7867972 |
Fusion protein of exendin-4 to a transferrin (Tf) polypeptide
The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and...
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7868142 |
Protein, method for immobilizing protein, structure, biosensor, nucleic acid, vector and kit for detecting target substance
It is intended to provide an anti-photocrosslinking group antibody capable of specifically binding to a photocrosslinking group and available in the binding of a substrate and a substance of...
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7862820 |
Immunoglobulin chimeric monomer-dimer hybrids
The invention relates to a chimeric monomer-dimer hybrid protein that comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an...
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7737260 |
Protein complex using an immunoglobulin fragment and method for the preparation thereof
Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an...
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7585491 |
Immunoconjugates with an intracellularly-cleavable linkage
The invention relates to therapeutic conjugates with improved ability to target various cancer cells containing a targeting moiety and a therapeutic moiety. The targeting and therapeutic moieties...
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7527787 |
Multivalent immunoglobulin-based bioactive assemblies
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred...
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7399644 |
Immunoassay, reagent for immunoassay, and production method of the same
An assay method for determining presence of a target antibody or antigen in a specimen qualitatively or quantitatively by mixing the specimen with an antigen or antibody immunologically reactive...
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7351807 |
Cyanine-sulfenates for dual phototherapy
Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080 where E is selected from the group...
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7306782 |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide...
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7262177 |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use
A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor,L represents a bifunctional linker, which does not comprise a...
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7247301 |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a...
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7166708 |
Process for preparing conjugate vaccines and the conjugate vaccines
This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate,...
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7157546 |
Water-soluble polymer alkanals
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
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7125541 |
Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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7122635 |
Method and composition for angiogenesis inhibition
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple...
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7112317 |
Combined methods and compositions for tumor vasculature targeting and tumor treatment
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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7074878 |
Hydrolytically degradable polymers and hydrogels made therefrom
A water soluble polymer is provided having two or more oligomers linked to each other by hydrolytically degradable carbonate linkages. The polymer can be hydrolytically degraded into oligomers...
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7041855 |
Monofunctional polyethylene glycol aldehydes
The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a...
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RE38994 |
Pyropheophorbides conjugates and their use in photodynamic therapy
Conjugate are formed by covalently linking a target-specific compound to pyropheophorbide compound which conjugated are injected into a host and accumulate in tumor tissue to a higher degree than...
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6942972 |
Efficient synthesis of protein-oligonucleotide conjugates
The present invention relates to an improved method for forming a protein-oligonucleotide conjugate. The method is particularly amenable for forming antibody-oligonucleotide conjugates. The...
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6913936 |
Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances
A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of...
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6884874 |
Process and intermediates
Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.
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6811785 |
Multivalent MHC class II—peptide chimeras
The present invention provides a multimeric complex of at least two chimeric molecules, wherein the chimeric molecules comprise an immunoglobulin constant region element and two MHC elements...
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6765087 |
Immunoglobulins devoid of light chains
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the...
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6756041 |
Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At...
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6677164 |
Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds
The present invention provides biologically active linear polypeptides that possess a plurality of biologically active groups, methods employing such peptides to target molecules to cells, and...
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6676941 |
Antibody conjugate formulations for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6645490 |
Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by a recombinant chimeric protein...
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6642007 |
Assays for measurement of type II collagen fragments in urine
This invention provides novel methods for monitoring urine for type II collagen fragment using a combination of a capture antibody and a detection antibody, such that type II collagen is...
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6642356 |
Peptides which function as hinge regions in protein
Peptides comprising the amino acid sequence set forth in SEQ ID NO:1 are described wherein the amino acid at position 7 of SEQ ID NO:1 and the amino acid at position 8 of SEQ ID NO:1, which may be...
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6623926 |
Methods for producing 5′-nucleic acid-protein conjugates
Disclosed herein is a method for generating a 5′-nucleic acid-protein conjugate, the method involving: (a) providing a nucleic acid which carries a reactive group at its 5′ end; (b) providing a non...
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6576445 |
Chemokine α-4
The present invention relates to a novel CKα-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-4 protein. C...
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6548645 |
Immunoassay for 2-oxo-3-hydroxy LSD
To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an...
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6451311 |
Anti-procalcitonin antibodies and the preparation and use thereof
The invention relates to anti-procalcitonin antibodies, their preparation and use, in particular in therapy and diagnostics. The antibodies comprise binding to procalcitonin but not to free...
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6451980 |
Signal enhancement of bispecific antibody-polymer probe for immunoassay use
An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a...
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6416758 |
Antibody conjugate kits for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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