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7306782 |
Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases
The present invention relates to a method for the preparation of a conjugate comprising a first and a second polypeptide, said method comprising the steps of (a) incubating said first polypeptide...
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7268219 |
Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means
A complex comprising an HLA Class 1 molecule and attaching means for selectively attaching the HLA class 1 molecule to a target cell is disclosed, and a method is provided for producing or...
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7238789 |
Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates
Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a...
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7229620 |
Method for radiolabeling antibodies with yttrium-90
Methods and kits for radiolabeling proteins, peptides and ligands with radiolytic isotopes, particularly yttrium-90, are disclosed, whereby sufficient purity, specific activity and binding affinity...
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7198958 |
Method for increasing hydrophilicity of fluorescent label compounds
A fluorescent label compound of formula
where Z is a reactive group that can be used for covalent coupling of the fluorescent label compound to other molecule. Either the fluorophore is a...
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7189816 |
Compounds
An antibody, or a derivate or a fragment thereof, having a binding structure for a target structure is described. The antibody is displayed in, and on the cell surface of, human gastrointestinal...
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7183392 |
Site-specific, covalent bioconjugation of proteins
Heterofunctional crosslinking groups are provided having the formula:
wherein W is a covalent core component; L 1 , L 2 and L 3 are independently linking groups; X is a non-covalent or...
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7172907 |
Cyanine dye labelling reagents with meso-substitution
Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1):
in which groups R 3 and R 4 are attached to...
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7153701 |
Method for quantitatively detecting antigen
A method for quantitatively detecting an antigen which comprises (1) a first step of providing an Fab′ antibody having a uniform isoelectric point, said antibody forming an immune complex with an...
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO 2 , —NH 2 , —NCS, —NHCOCH 2 -Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH 2 -Q, or...
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7118741 |
Transepithelial transport of molecular species
There is disclosed a synthetic cross-linker protein capable of binding a molecule or macromolecular species to a transcytosis receptor for transport of the molecule or macromolecule species across...
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7105160 |
Antibody-serum protein hybrids
Hybrid proteins are described which comprise one or more antigen-binding antibody fragments covalently linked to one or more serum carrier proteins. The hybrid proteins can bind antigens, have a...
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7048925 |
Acid-sensitive polyacetals and methods
Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II):
wherein A comprises at least one acetal group; B is selected...
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z,...
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7045605 |
Modified antibodies to prostate-specific membrane antigen and uses thereof
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or...
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7018851 |
Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
This invention relates to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of formula (I)
wherein
R 1 is selected from the group consisting H, —COOH,...
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RE39047 |
Luminescence by reacting an acridinium ester with superoxide
A light emitting method of an acridinium ester, comprising reacting said acridinium ester and a superoxide anion, and a method of detecting a substance to be examined, comprising detecting a light...
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RE38994 |
Pyropheophorbides conjugates and their use in photodynamic therapy
Conjugate are formed by covalently linking a target-specific compound to pyropheophorbide compound which conjugated are injected into a host and accumulate in tumor tissue to a higher degree than...
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6998106 |
Radioconjugation of internalizing antibodies
Antibodies to cell surface ligands such as EGFRvIII can be used to therapeutically or diagnostically deliver a radiolabel to tumor cells with high selectivity. The utility of radioconjugated...
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6994840 |
Kit for radiolabeling ligands with yttrium-90
Methods and kits for radiolabeling proteins, peptides and ligands with radiolytic isotopes, particularly yttrium-90, are disclosed, whereby sufficient purity, specific activity and binding affinity...
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6979575 |
Fluorochromes for labelling biomolecules and polymer particles and bioanalytical and screening methods based thereon
New reactive dyes are described which can be used to fluorescently label bioorganic molecules such as amino acids, proteins, antibodies, nucleotides and also polymer particles. The color of the new...
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6953667 |
Antibodies against human protein HUVDJ43
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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6924154 |
Hydrophilic chemilumescent acridinium labeling reagents
In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid,...
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6890724 |
Methods and compositions for neural progenitor cells
The invention relates to methods and compositions for the isolation of neural progenitor cells.
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6878374 |
Biodegradable polyacetals
A polymer comprising recurring units represented by formula (I):
wherein X is selected from the group consisting of C(O)OR 1 , C(O)SR 1 , C(O)NR 1 R 2 , and VZ, where R 1 and R 2 are...
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6844425 |
Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of...
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6818417 |
Method for locating hidden microorganism contaminated surfaces in industrial water systems
A method for locating hidden microorganism contaminated surfaces in industrial water systems is described and claimed. The method works by applying a solution or dispersion of a fluorogenic reagent...
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6811785 |
Multivalent MHC class II—peptide chimeras
The present invention provides a multimeric complex of at least two chimeric molecules, wherein the chimeric molecules comprise an immunoglobulin constant region element and two MHC elements...
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6808939 |
ECL labels having improved non-specific binding properties, methods of using and kits containing the same
Bipyridine or phenanthroline ligands presenting functional groups that prevent non-specific binding (in particular, negatively charged functional groups that are unaffected by standard conditions...
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6803059 |
Anti-tumor metallocomplexes of crude extracts from Canavalia ensiformis
An anti-tumor pharmaceutical composition comprises the conjugation of Canavalia ensiformis -extracted protein with metal ions to form a metalloprotein complex for inhibiting the growth of tumor...
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6774228 |
Tetra-aza macrocycles and metal complexes thereof
1,4,7,10-Tetrazacyclododecanes carrying a side chain terminating in a group capable of reacting with an antibody, and their complexes with a di- or tripositive metal having a coordination number of...
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6765087 |
Immunoglobulins devoid of light chains
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the...
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6737279 |
Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform
The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property...
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6716967 |
Rupestris stem pitting associated virus nucleic acids, proteins, and their uses
This invention relates to purified monoclonal antibodies that specifically bind to a Rupestris stem pitting associated virus coat protein or coat protein polypeptide, and methods of detecting a...
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6676941 |
Antibody conjugate formulations for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6664043 |
Acridinium ester labels having hydrophilic modifiers
The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such...
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6645724 |
Assays for endotoxin
The horseshoe crab, Carcinoscorpius rotundicauda Factor C cDNA (CrFC21) has been cloned into a shuttle baculoviral vector and another vector suitable for expression in insect cells. The...
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6642356 |
Peptides which function as hinge regions in protein
Peptides comprising the amino acid sequence set forth in SEQ ID NO:1 are described wherein the amino acid at position 7 of SEQ ID NO:1 and the amino acid at position 8 of SEQ ID NO:1, which may...
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6642007 |
Assays for measurement of type II collagen fragments in urine
This invention provides novel methods for monitoring urine for type II collagen fragment using a combination of a capture antibody and a detection antibody, such that type II collagen is...
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6627460 |
Method for preparing water-soluble cross-linked conjugates
A novel preparative methodology yields water-soluble, cross-linked conjugates and conjugate complexes that confer an improved sensitivity in immunochemical assays, particularly in the context of...
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6623926 |
Methods for producing 5′-nucleic acid-protein conjugates
Disclosed herein is a method for generating a 5′-nucleic acid-protein conjugate, the method involving: (a) providing a nucleic acid which carries a reactive group at its 5′ end; (b) providing a...
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6613583 |
Electrochemiluminescent label based on multimetallic assemblies
Electrochemiluminescent label compounds containing multimetallic centers separated by bridging ligands are described. An example of a multimetallic electrochemiluminescent label suitable for use in...
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6602989 |
Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents
The detection of gallium in biological samples is required due to its role in the diagnosis of tumor and for possible treatment of malignancies. However, the use of purely instrumental techniques...
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6582930 |
Porphyrin compounds, their conjugates and assay methods based on the use of said conjugates
The preparation of phosphorescent metalloporphyrin labelling reagents and their use for preparation of phosphorescent conjugates with biomolecules. The labelling reagents obtainable are water...
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6576746 |
Site-specific labeling of disulfide-containing targeting vectors
A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and...
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6576445 |
Chemokine α-4
The present invention relates to a novel CKα-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-4 protein....
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6565827 |
Radioimmunotherapy of lymphoma using anti-CD20 antibodies
Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies...
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6531278 |
Ligand-DNA composition for capture and detection of contaminants on a solid surface
Compositions and methods of use thereof for capture and detection of selected molecules are described. In one embodiment, a first composition includes a ligand component, such as an antibody...
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6495137 |
Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains
Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
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6482648 |
Stable troponin preparation and the use thereof as a calibrator/control in immunoassays
The present invention relates to methods for the production of a stable troponin preparation and its use as a calibrator and/or control in immunoassays. The formulation is prepared from mammalian,...
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