|
Match
|
Document |
Document Title |
|
|
7385040 |
Antibody purification
The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support...
|
|
|
7368542 |
Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions
The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter...
|
|
|
RE40070 |
Antibody purification
This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins. The questions raised in...
|
|
|
7183391 |
Kunitz domain polypeptide zkun10
We claim the proteinase inhibitors comprising a Kunitz domain, wherein the Kunitz domain comprises amino acid residues 57–107 of SEQ ID NO: 2. We also claim a fusion protein comprising said...
|
|
|
7138120 |
Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion...
|
|
|
7118675 |
Process for removing protein aggregates and virus from a protein solution
A process is provided for selectively removing protein aggregates from a protein solution in a normal flow (NFF) filtration process. Preferably, it relates to a process for selectively removing...
|
|
|
7041798 |
Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use
The invention relates to the fractionation of plasma or serum into at least one albumin fraction and one immunoglobulin fraction by hydrophobic interaction chromatography. The fractionation is...
|
|
|
6893639 |
Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
The method for immune serum globulin purification relates to the purification of immune globulins from blood plasma with a high degree of efficiency and a high rate of recovery. The immune globulin...
|
|
|
6875848 |
Process for the production of virus-inactivated human gammaglobulin G
The gammaglobulin is extracted from a fraction isolated by fractionation with ethanol in the presence of a carbohydrate, and after reducing the content of contaminants with PEG, it is applied to an...
|
|
|
6875432 |
Reduced-viscosity concentrated protein formulations
The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method...
|
|
|
6737405 |
Stabilized protein preparation and process for its preparation
A stabilized protein preparation is described which contains no antithrombin III and is protected against loss of activity during pasteurization by the addition of stabilizers which comprise one or...
|
|
|
6709655 |
Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof
The present invention is directed to a pharmaceutical composition comprising F(ab′) 2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free...
|
|
|
6646108 |
Process for isolating IgG and IgA
A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a...
|
|
|
6504012 |
Method for preparing dual virally inactivated immune globulin for intravenous administration
A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the...
|
|
|
6485725 |
Room temperature storable immunoglobulin preparation for intravenous injection
A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v% of polyethylene...
|
|
|
6307028 |
Chromatographic method for high yield purification and viral inactivation of antibodies
An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of...
|
|
|
6281336 |
Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion...
|
|
|
6252055 |
Concentrated antibody preparation
Concentrated monoclonal antibody preparations for administration to humans are described in which the antibody is present at a concentration of greater than 100 mg/ml and as high as 350 mg/ml.
|
|
|
6177548 |
Enhanced aggregate removal from bulk biologicals using ion exchange chromatography
Disclosed are methods and processes for removing aggregates and other impurities from partially purified protein bulk product, in particular, from partially purified monoclonal antibody, using...
|
|
|
6165467 |
Stabilized human monoclonal antibody preparation
A stabilized human monoclonal antibody preparation containing 1 to 20 mg of D-mannitol per 1 mg of a human monoclonal antibody. This preparation is excellent in stability in a solution state, a...
|
|
|
6162904 |
Manufacturing method for intraveneously administrable immune globulin and resultant product
A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by heat treating for viral inactivation and fractionating an impure gamma...
|
|
|
6136312 |
Method for producing an IgM preparation for intravenous application
In the method for producing an immunoglobulin solution suitable for intravenous application with an IgM proportion of more than 5% by weight with respect to the immunoglobulin proportion, an...
|
|
|
6124437 |
Immunoglobulin preparation and preparation process thereof
An immunoglobulin preparation comprising an immunoglobulin, wherein the preparation contains, as a contaminant, serum albumin in an amount not greater than 10 μg per 50 mg of immunoglobulin;...
|
|
|
6090380 |
Treatment of rheumatoid arthritis by oral administration of pooled human immunoglobulin
Pooled human immunoglobulin may be administered orally to rheumatoid arthritis patients to treat the rheumatoid arthritic condition of those patients. Oral administration of pooled human...
|
|
|
5972632 |
Anticomplement activity assays
Immunoassays for complement components, complement activation products or, preferably both, can be used to determine an acceptable level of anticomplement activity (AC) in plasma derived...
|
|
|
5945098 |
Stable intravenously-administrable immune globulin preparation
Stable, intravenously-administrable immune globulin preparations are stabilized against aggregation and polymerization and rendered isotonic with amino acid(s) and non-ionic detergents, polysorbate...
|
|
|
5917021 |
Stabilized monomeric protein compositions
The present invention relates to a stabilized protein composition comprising a monomeric protein and a storage-stabilizing amount of sucrose, histidine or glycine, which is sufficient to inhibit...
|
|
|
5889157 |
Humanized B3 antibody fragments, fusion proteins, and uses thereof
This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More...
|
|
|
5871736 |
Liquid immunoglobulin formulations
Immunoglobulin preparations, particularly liquid preparations of immunogllin G for intravenous infusion, are stabilized against dimer formation by the addition of one or more amphiphilic...
|
|
|
5780593 |
Method of isolating biomolecules by ion exchange
A method of isolating a biomolecule from a medium containing biomolecules by ion exchange wherein the ion exchange material consists of a material having ion exchanging groups which can be...
|
|
|
5670623 |
Methods of use of cellulose binding domain proteins
A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion...
|
|
|
5665866 |
Process for obtaining antibodies utilizing heat treatment
This invention relates to a process for obtaining antibodies in soluble and correctly folded and assembled form. It comprises a step to raise the temperature at a time in the process selected to...
|
|
|
5654403 |
Immunoglobulins stabilized with a chelator of copper ions
A stabilized immunoglobulin composition comprises at least one immunoglobulin together with a stabilizing amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin...
|
|
|
5641870 |
Low pH hydrophobic interaction chromatography for antibody purification
A process for purifying an antibody is provided. In this process, a mixture containing the antibody and contaminant is subjected to low pH hydrophobic interaction chromatography (LPHIC) optionally...
|
|
|
5612033 |
Methods of treatment using heat-treated IGM antibody preparations
Mild heat-treatment of IgM antibody concentrates diminishes the potential to induce non-specific complement activation without significant loss of normal immunologic effector functions. These IgM...
|
|
|
5602234 |
Stable antibody solution and method for preparing same
An antibody solution containing (1) an antibody or a labelled antibody, (2) albumin, and (3) an azo dye containing naphthalenesulfonic acid in its structure and a method for stabilizing an antibody...
|
|
|
5548066 |
Failure of passive transfer immune serum and method of making same
An immunological serum and method of making same. The serum essentially consists of purified and concentrated materials, sometimes known as transfer factor, and immunoglobulins, expressed from the...
|
|
|
5510465 |
Heat-treated IgM antibody preparations
Mild heat-treatment of IgM antibody concentrates diminishes the potential to induce non-specific complement activation without significant loss of normal immunologic effector functions. These IgM...
|
|
|
5410025 |
Unmodified intravenously administered immunoglobulin preparations containing immunoglobulin M and/or A
Intravenously administered chemically unmodified immunoglobulin preparation containing more than 5% of its total immunoglobulin by weight consisting of IgM and/or more than 10% of its total...
|
|
|
5371196 |
Process for producing secretory immunoglobulin A preparations
Secretory immunoglobulin A preparations substantially not containing virus are produced by a process wherein secretory immunoglobulin A which might be contaminated with viruses is (1) heated about...
|
|
|
5362859 |
High-capacity affinity supports and methods for the preparation and use of same
An affinity support having an improved capacity for binding target compounds. The support includes an immobilized modified ligand of increased molecular weight. The molecular weight of the ligand...
|
|
|
5359038 |
Method for isolating immunoglobulin compounds in the feces
A method for isolating the immunoglobulin compounds in the feces of animals and humans including the steps of placing said feces in a container with a buffer solution, homogenizing the feces in a...
|
|
|
5310877 |
Method for separating serum albumin and gamma globulin
The invention is directed to a method for the separation of gamma globulin from albumin contained in an aqueous solution of both having a pH of 8-10 by ultrafiltration using an altered substrate...
|
|
|
5256771 |
Heat treatment of IgM-containing immunoglobulins to eliminate non-specific complement activation
Mild heat-treatment of IgM antibody concentrates diminishes the potential to induce non-specific complement activation without significant loss of normal immunologic effector functions. These IgM...
|
|
|
5248767 |
Process for the preparation of a pasteurized immunoglobulin preparation using ethanol
A process for the production of a pasteurized immunoglobulin preparation is described, which comprises heating a solution of an immunoglobulin in the presence of a carboxylic acid or one of its...
|
|
|
5245016 |
Pseudomonas maltophilia immunoglobulin binding protein and methods for its use
A protein isolated from Pseudomonas maltophilia is found to possess an exposed, immunologically accessible protein which binds to the FC region of several species of immunoglobulins. The protein is...
|
|
|
5219999 |
Immunoglobulin G and process for the production thereof
Crude immunoglobulin G isolated from human blood plasma is treated according to a conventional technique (such as the tricalcium phosphate adsorption method) to remove aggregates therefrom to such...
|
|
|
5190752 |
Intravenously administerable polyclonal immunoglobulin preparation containing IgM and method of manufacture
An intravenously administrable polyclonal immunoglobulin preparation for the treatment and prophylaxis of bacterial infections containing at least 50% by weight of IgM in terms of the total content...
|
|
|
5177194 |
Process for purifying immune serum globulins
A multi-step process for purifying an immune serum globulin fraction from a crude plasma protein fraction involves precipitating non-serum globulin proteins from an aqueous suspension of the crude...
|
|
|
5164487 |
Manufacturing intravenous tolerable immunoglobulin-G preparation
Method of manufacturing an intravenously tolerable immunoglobulin-G preparation that is free of aggregates, vasoactive substances and proteolytic enzymes and accordingly appropriate for all types...
|