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7638291 |
Immunoassays for topiramate
Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic...
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7569358 |
Doxorubicin immunoassay
Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are...
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7541330 |
Conjugates with reduced adverse systemic effects
A conjugate of an active agent and a targeting moiety having affinity for a target cell, in which the active agent has been modified by attachment of a cell membrane-impermeabilizing group so that,...
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7498421 |
Degradation fragments
A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y 1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO 2 R 4 , —CO 2 R...
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7459281 |
Docetaxel immunoassay
Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in...
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7402398 |
Measuring receptor homodimerization
The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds...
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7399470 |
Sandwich immunoassay kits for detecting ciguatoxin CTX3C
A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession...
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7385039 |
Methods and compositions for regulating imidazoline receptors
The present invention relates to methods and compositions for regulating the activity of imidazoline receptors. In particular, the invention relates to pharmaceutical compositions comprising...
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7378505 |
Assay method for group transfer reactions
The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer...
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7371829 |
Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites
The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as,...
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7344714 |
Production of motif-specific and context-independent antibodies using peptide libraries as antigens
The present invention is related to a method for producing motif-specific, context-independent antibodies which are specific to at least one modified amino acid residue in the context of variable...
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7276347 |
Cytoxan antibodies and immunoassay
Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and...
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7229782 |
Antibodies specific to multiple beta blockers and methods for their use
The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies.
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7223553 |
Immunoassays for everolimus
Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided.
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7220842 |
Immunoassays for buprenorphine and norbuprenorphine
Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination...
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7205116 |
5-Fluoro-uracil immunoassay
Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and...
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7202348 |
Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused...
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7193065 |
Protease inhibitor conjugates and antibodies useful in immunoassay
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in...
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7192722 |
Phenethanolamine-derived haptens, immunogens, antibodies and conjugates
The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays...
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7189582 |
Compositions and methods for detection of sirolimus
Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at...
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7175993 |
Taxol immunoassay
Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for...
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7169907 |
Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
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7157561 |
Methods of inhibiting transmission of a costimulatory signal of lymphocytes
Activated haptens useful for generating immunogens to the HIV protease inhibitor atazanavir, immunogens useful for producing antibodies to atazanavir, and antibodies and labeled conjugates useful...
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7148029 |
Immunoassay for neonicotinyl insecticides
The present invention provides immunogens for generating anti-neonicotinoid antibodies as well as antibodies, methods, reagents and kits for determining the presence of one or more neonicotinoid...
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7148024 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7138504 |
Reagents and methods for mycophenolic acid immunoassay
The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic...
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7115383 |
Assays for amphetamine and methamphetamine
Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group...
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7115718 |
Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD
The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned...
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7109310 |
Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as...
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7101980 |
Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
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7078495 |
Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus
An IgG 1 λ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several...
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7037669 |
Assays for amphetamine and methamphetamine using stereospecific reagents
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of...
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7026134 |
Haptens, immunogens and antibodies to oxycodone and its metabolites
Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III
wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional...
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7022492 |
Ecstasy haptens and immunogens
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a...
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6991911 |
Assay for entactogens
Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA),...
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6967240 |
Congener independent detection of microcystin and nodularin congeners
The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of...
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6946547 |
Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class...
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6932969 |
Ig fractions having immunomodulatory activity
The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect...
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6911534 |
Method for determination of water treatment polymers
A method for determining the presence and/or concentration of a water treatment polymer in an aqueous sample, comprising producing a polyclonal or monoclonal antibody to the water treatment...
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6869606 |
Biotinylated-chemokine antibody complexes
Biotinylated pharmacologically active agents and complexes containing same are disclosed. In particular, biotinylated-chemokines are described. The complexes further include an anti-biotin antibody...
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6780978 |
Fluorescence-activating antisera and IgG fraction therefrom
This invention allows the fluorescence analysis of a nonfluorescent dye with high specificity and high sensitivity by virtue of the formation of a complex among an antibody directed against an...
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6750328 |
Antibodies for detection of water treatment polymers
The invention provides an antibody having an affinity to water treatment polymers. The antibodies of the invention are used in assays to determine the presence or concentration of a water treatment...
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6743771 |
Methods and compositions for controlling protein assembly or aggregation
Compositions and methods for controlling prepathological and pathological protein assembly or aggregation using picolinic acid, analogs, or derivatives thereof are described. The compositions of...
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6719975 |
Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.
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6699474 |
Vaccine and immunserum against drugs of abuse
Addictive drugs like cocaine, heroin or amphetamines are spreading in an epidemic manner in the western world and are an important factor in the spread of the acquired immune deficiency syndrome...
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6613537 |
Pyrrolopyridinium derivatives
The present invention is drawn to pyrrolopyridinium derivatives having a new structural skeleton, preferably containing an intramolecular hemiacetal, which is clearly different from any known...
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6610502 |
Compound 2-amino-3-&lsqb 2-(α-mannopyranosyl)indol-3-yl&rsqb propionic acid, process for preparing the same, and method for inspecting function of living body with the novel compound
The present invention relates to a novel endogenous compound 2-amino-3-[2-(α-mannopyranosyl)indole-3-yl]propionic acid; to a method for testing a biological function by quantitating...
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6576746 |
Site-specific labeling of disulfide-containing targeting vectors
A method of producing a diagnostic or therapeutic conjugate of a protein, polypeptide or peptide containing at least one disulfide bond which is necessary to maintain its biological activity, and...
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6548645 |
Immunoassay for 2-oxo-3-hydroxy LSD
To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an...
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6541004 |
Cocaethylene immunogens and antibodies
The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for...
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