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7364737 |
Human neutralizing monoclonal antibodies to respiratory syncytial virus
Human monoclonal antibodies and fragments thereof which bind, neutralize and provide passive immunotherapy to respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also...
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7314919 |
Human recombinant antibody against the hepatitis C (HCV) non structural NS3 protein nucleic acid and uses thereof
An human antibody anti-NS3 protein of the hepatitis C virus (HCV) is described, as will as synthetic and recombinant fragments thereof able to inhibit the helicase activity of the NS3 protein, both...
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7244427 |
Isolated bovine IgG heavy chain protein and its use as an antimicrobial
A new protein derived from acid hydrolyzed IgG concentrate which has a molecular weight of about 55,000, and is activated by heat within the defined narrow temperature range provides resulting...
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7112664 |
Variable region of the monoclonal antibody against the HBV S-surface antigen and a gene encoding the same
The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatis B virus and a gene encoding the same, a recombinant vector containing the said...
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7101554 |
Picornaviruses, vaccines and diagnostic kits
A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (I)...
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7091324 |
Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes
Conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with...
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7087377 |
Method and kit for detection of tat protein with anti-tat oyi antibodies
The invention relates to an anti HIV 1 vaccine comprising the entire or part of the Tat HIV 1 protein, in addition to the identification of said protein in individuals affected by HIV. The Tat...
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7067638 |
Small round structured virus (SRSV) detection kit
This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related which makes it possible to detect most SRSV-related viruses and further to distinguish their serotypes...
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7033593 |
Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
The invention relates to an immunogen comprising an HIV envelope protein bound to a ligand, which ligand upregulates at least one of the CD4 binding site and the CCR5 binding site on the protein,...
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7008622 |
Methods and compositions for impairing multiplication of HIV-1
A composition which elicits antibodies to greater than 95%, and even greater than 99%, of the known variants of HIV-1 Tat protein contains at least one peptide or polypeptide of the formula of...
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6984721 |
Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins GP300, P200, and P90/80
Immunological reagents obtained from multimeric forms of the HIV-2 and SIV envelope glycoproteins and their use in the detection of HIV-2, particularly, the HIV-2 proteins gp300, p200, p90, and...
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6982156 |
Compositions and methods modulating variola and vaccinia virus
Antibodies directed to SPICE and VCP which may be used for detection, prevention, and treatment of variola virus or vaccinia virus are provided. Recombinant SPICE and VCP proteins are also provided...
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6939954 |
Isolated bovine lgG heavy chain protein and its use as an antimicrobial
A new protein derived from acid hydrolyzed IgG concentrate which has a molecular weight of about 55,000, and is activated by heat within the defined narrow temperature range provides resulting...
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6927281 |
Adeno-associated virus-its diagnostic use with early abortion
The present invention relates to a method of detecting a causative agent of the so-called spontaneous early abortion by investigating patients' samples for the presence of adeno-associated virias...
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6824778 |
Prophylactic and therapeutic monoclonal antibodies
In this application are described monoclonal antibodies which recognize E3 glycoprotein of alphavirus and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of...
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6818748 |
Cloning, expression, sequencing, and functional enhancement of monoclonal ScFv antibody against Venezuelan equine encephalitis virus (VEE)
A single chain variable fragment (ScFv) antibody from a monoclonal antibody (Mab) against Venezuelan equine encephalitis (VEE) virus, is generated by cloning linked variable regions of the heavy (V...
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6682909 |
Immunogenic composition of hepatitis C and methods of use thereof
The present invention provides truncated HCV E2 polypepides. The invention HCV E2 polypeptides lack the HVR1 region that provides immune protection against HCV. The present invention also provides...
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6677127 |
Nucleic acid respiratory syncytial virus vaccines
Vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described. Such...
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6670466 |
Human endogenous retrovirus in breast cancer
The present invention is related to mammary tumor virus (MTV). MTV represents a group of retroviruses which possess very high homology to mouse mammary tumor virus (MMTV), a virus known to cause...
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6610303 |
Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. In addition, this invention concerns proteins coded by the...
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6610295 |
Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor
HCMV glycoproteins B and H have been identified. The gB protein is encoded by DNA in the HindIII F fragment of the HCMV genome lying between 1378 and 4095 bases from the F/D boundary. The gH...
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6608179 |
Antibodies, that bind to HIV-2 transmembrane glycoprotein homodimer (gp 80)
Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for...
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6600023 |
Antibody directed against HIV-1 P25 antigen
Antibodies which bind with antigens of human immunodeficiency virus type 1 (HIV-1), such as Lymphadenopathy Associated Virus (LAV), are disclosed. Retroviruses associated with Acquired Immune...
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6596497 |
Screening of antiviral compounds targeted to the HIV-1 gp41 core structure
A method for the screening of antiviral compounds targeted to the HIV gp41 core structure comprising capturing polyclonal antibodies from an animal other than a mouse directed against a trimer of a...
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6557296 |
Non-infectious, protease defective HIV particles and nucleic acid molecules encoding therefor
This invention is directed toward mutated DNA, proteins, or protein fragments and particles from the L-2 cell line. The invention is also directed to diagnostic, prophylactic and therapeutic...
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6528057 |
Method for removal of HIV and other viruses from blood
This invention discloses a method for reducing the viral load by removal of viruses or fragments or components thereof from the blood by extracorporeally circulating blood through hollow fibers...
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6413515 |
Avian, vitelline antibodies directed against HIV antigens
The present invention is drawn to avian vitellin antibodies that are immunologically reactive with HIV antigens, a process for the preparation thereof, a use thereof and a food substance in the...
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6372216 |
Method of producing specific immunoglobin to block HCV infection
A drug which protects individuals against hepatitis C virus (HCV) is made of HCV hyperimmune globulins, which guarantee a substantial hyperimmunity against HCV thanks to a substantial...
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6322794 |
Seroreactive epitopes on proteins of human papillomavirus (HPV) 18
The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or...
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6297355 |
Polypeptides displaying HBV antigenicity or hbv antigen specificity
Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts,...
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6270955 |
Pharmaceutical compositions and methods for producing antibodies to hepatitis b virus and kits and methods for detecting antibodies to hepatitis b virus
Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV anti-genicity and genes coding therefor and methods of making and using these molecules, hosts,...
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6268122 |
Recombinant DNA molecules and their method of production
Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts,...
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6235284 |
Synthetic polypeptides belonging to the hepatitis C virus (HCV) and which can be used especially for detecting the latter
The invention relates to a polypeptide comprising a peptide sequence belonging to the sequence of the first 62 amino acids of the terminal part of the CORE (or capsid) protein of the human...
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6190859 |
Method and kit for detection of dengue virus
An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable...
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6174685 |
Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use
The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the...
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6171596 |
Oligomeric HIV-1 envelope glycoproteins
Immunogenic compositions and methods of stimulating an immune response against the envelope protein of HIV-1. Immunogenic compositions include a purified oligomeric structure that comprises a...
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6165710 |
Method for immobilizing viral glycoproteins for use in solid-phase immunoassays
A process for selectively immobilizing viral glycoproteins on lectin-coated surfaces for use in solid phase immunoassays is disclosed. This method does not require that the virus or antigen be...
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6156883 |
Polyclonal and monoclonal antibodies to Norwalk virus and methods for making them
Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13...
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6156314 |
Chimeric infectious bursal disease virus cDNA clones, expression products and vaccines based thereon
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal...
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6140043 |
Pharmaceutical compositions for competitively inhibiting the binding of a retrovirus to the IFN-receptor and means for diagnosis of an HIV infection
The present invention is based on the observation that HIV does not only interact with the CD4 receptor of target cells but that there exists a different type of interaction between HIV envelope...
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6136319 |
Method of treating viral diseases in animals
A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a...
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6121006 |
Immunoassay utilizing two incubations with labeled antigen
The present invention relates to an immunoassay for antibodies against an infectious agent. The present invention also relates to the use of the immunoassay and a kit for performing the immunoassay...
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RE36866 |
Anti-aids immunotoxins
The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptase. Also...
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6107020 |
Model for protective and pathogenic roles of HIV-1 env-directed antibody dependent cellular cytotoxicity interaction with viral load, and uses thereof
Methods and kits for diagnosing the presence of and prognosing the of stages of HIV disease, involving correlating rate of CD4% decline, CMC activity and plasma HIV RNA load, are disclosed. In...
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6103878 |
Antibody to carboxy-terminus of human herpesvirus 6 immediate early protein
An antibody raised against an epitope of a peptide having an amino acid sequence selected from a group consisting of Leu Asp Gly Tyr Pro Ser Asp Tyr Asp Pro Phe Val Glu Asn Ala Gln Ile Tyr (SEQ ID...
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6099840 |
Hepatitis B vaccine
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a...
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6077511 |
Antigenic peptide derived from the G protein of RSV for type- and subtype-specific diagnosis of respiratory syncytial virus (RSV) infection
Antigenic substance or precursor thereof comprising a peptide part derived from an amino acid sequence located between two mucin-like regions of a protein G of a respiratory syncytial virus (RSV)....
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6071516 |
Treatment of Post-Polio Syndrome with gamma-globulin
A method for treating a patient suffering from Post-Polio Syndrome (PPS) comprises the intravenous, intramuscular or subcutaneous administration of a pharmacologically effective amount of an...
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6060254 |
Reagent for examining agglutination of virus and kit for virus examination
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6040146 |
Detection of mammary tumor virus-like sequences in human breast cancer
The present invention relates to materials and methods for diagnosing breast cancer in humans. It is based, at least in part, on the discovery that a substantial percentage of human breast cancer...
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