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7632497 |
Engineering Fc Antibody regions to confer effector function
The present invention relates to molecules having a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region. These...
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7632498 |
MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that...
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7625859 |
HER-2 binding antagonists
There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an iso lated polypeptide having from...
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7615216 |
Antibodies against CCR5 and uses thereof
Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease.
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7615372 |
Antibodies with immune effector activity and that internalize in endosialin-positive cells
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing endosialin and...
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7611706 |
RG1 antibodies and uses thereof
The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and...
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7611708 |
Methods of therapy for B-cell malignancies using antagonist anti-CD40 antibodies
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608263 |
RG1 antibodies and uses thereof
The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and...
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7604799 |
EphA4 Antibodies
The invention provides agonistic anti-EphA4 antibodies.
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7595380 |
Monoclonal antibodies and methods for their use in the detection of cervical disease
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that...
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7595379 |
Antibodies and related molecules that bind to PSCA proteins
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is...
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7589181 |
Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use
Humanized anti-TAG-72 CC49 monoclonal antibodies are disclosed herein. The antibodies include a light chain Complementarity Determining Region (L-CDR)1, a L-CDR2, and a L-CDR3; and a heavy chain...
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7589180 |
Specific binding proteins and uses thereof
The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant...
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7585953 |
Antibodies specific for TAT285-1
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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7575922 |
Polypeptide and gene encoding the same
A polypeptide having the amino acid sequence as set forth in SEQ ID NO: 2, 4, or 6, a DNA encoding the same, and an antibody against said polypeptide, and the use thereof. The above amino acid...
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7572895 |
Transferrin receptor antibodies
The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the...
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7572897 |
Antibodies against insulin-like growth factor I receptor and uses thereof
Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed....
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7572442 |
Selected antibody compositions for binding to aminophospholipids
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7569673 |
Humanized anti-tag 72 cc49 for diagnosis and therapy of human tumors
The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody...
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7569356 |
Diagnosis and therapy of cancer using SGP28-related molecules
The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins...
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7563882 |
Polynucleotides encoding antibodies that bind to the C35 polypeptide
The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human...
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7563439 |
Production and use of novel peptide-based agents for use with bi-specific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a...
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7560111 |
HER2 antibody composition
A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed....
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7550143 |
Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular...
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7547768 |
Anti-TAT 113 antibodies
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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7547544 |
Antibodies against GPR64 and uses thereof
GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing...
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7541160 |
ELISA for VEGF
The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions,...
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7541442 |
Antibodies and related molecules that bind to PSCA proteins
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is...
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7541437 |
Breast cancer resistance protein (BCRP) and the DNA which encode it
The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.
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7538195 |
Anti-IGF-I receptor antibody
Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit...
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7534431 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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7531643 |
Monoclonal antibody inducing apoptosis
The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having...
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7527786 |
Methods for inhibiting the growth of cancer cells expressing PSCA
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade...
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7524498 |
Human immunomodulatory monoclonal antibodies for the treatment of cancer
The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
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7521047 |
Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells
The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in...
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7521543 |
A34 and A33-like 3 DNA, proteins, antibodies thereto and methods of treatment using same
Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33like 3. Also described are methods of detecting...
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7521542 |
Humanized FcγRIIB-specific antibodies and methods of use thereof
The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention...
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7517967 |
Monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma
The present invention relates to monoclonal antibody 1A7. This is an anti-idiotype produced by immunizing with an antibody specific for ganglioside GD2, and identifying a hybridoma secreting...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7514221 |
Diagnostic assay and method of treatment involving macrophage inhibitory cytokine-1 (MIC-1)
Methods for diagnosing risk of miscarriage and/or premature birth. The method comprises (i) determining the amount of (MIC-1) present in a body sample taken from a pregnant test subject having a...
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7514538 |
Compositions and methods for the diagnosis and treatment of tumor
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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7511123 |
Immuno-interactive fragments of the alpha-C subunit of inhibin
Novels immuno-interactive fragments of the (alpha)C portion of a mammalian inhibin alpha subunit are disclosed, together with their variants and derivatives for producing antigen-binding molecules...
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7495081 |
Framework patched anti-CD20 antibody
Framework (FR)-patching is a novel approach to modify immunoglobulin for reducing potential immunogenicity without significant alterations in specificity and affinity. Unlike previous described...
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7495083 |
PRO940 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7491801 |
Identification and development of specific monoclonal antibodies to squamous cell carcinoma
The present invention relates to novel antibodies, antibody fragments and antibody conjugates which display a high degree of selectivity for squamous cell carcinoma antigens including carcinomas of...
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7491514 |
Reducing the immunogenicity of anti-CD20 antibodies by framework patching
Framework (FR)-patching is a novel approach to modify immunoglobulin for reducing potential immunogenicity without significant alterations in specificity and affinity. Unlike previous described...
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7488475 |
Antibody therapy of tumors
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer...
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7485621 |
Tumor tag and the use thereof
The invention provides a new tumor tag, RL5 protein, the polynucleotide encoding RL5 protein, and the method of producing RL5 protein by recombinant technology. The invention also discloses the use...
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7485296 |
PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade...
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