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8153129 |
Antibodies against human cytimegalovirus (HCMV)
The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV...
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8148497 |
Binding molecules capable of neutralizing rabies virus and uses thereof
The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding...
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8142791 |
Multi-modal cancer therapy using viral hitch-hiking
The present invention relates to an antibody fusion protein which specifically recognizes the VA, HN or F surface antigen of the New Castle Disease Virus (NDV), a surface molecule of a...
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8124092 |
Antibodies against H5N1 strains of influenza A virus
Provided are human antibodies that can neutralize a H5N1 strain of influenza A virus. Also provided are antibodies that can neutralize a strain of influenza A virus in clade 2 of the H5 subtype,...
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8124093 |
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a...
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8114402 |
Compositions and methods for the therapy and diagnosis of influenza
The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
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8114586 |
Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
Conformational epitopes of the envelope proteins E1 and E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients...
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8106169 |
Plant production of immunoglobulins with reduced fucosylation
This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the...
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8057796 |
Compositions and methods for the therapy and diagnosis of influenza
The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
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7988971 |
Human monoclonal antibodies against Hendra and Nipah viruses
The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah...
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7988972 |
Immunoreactive peptides from Epstein-Barr virus
The Epstein-Barr virus (EBV) specific polypeptides ETFTETWNRFITHTE (SEQ. ID NO: 1), GMLEASEGLDGWIHQ (SEQ. ID NO:2), HQQGGWSTLIEDNIP (SEQ. ID NO:3), and KQKHPKKVKQAFNPL (SEQ. ID NO:4) are among...
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7959922 |
Liquid anti-rabies antibody formulations
The present invention provides pharmaceutical antibody formulations, in particular liquid pharmaceutical formulations comprising anti-rabies virus antibodies. The formulations can be used in the...
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7955599 |
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralising antibodies which are specific for human cytomegalovirus and bind with high affinity as well as immortalised B cells that produce such antibodies. The invention...
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7947274 |
Human cytomegalovirus neutralising antibodies and use thereof
The invention relates to neutralizing antibodies and antibody fragments having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for a combination of...
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7919314 |
Process for the production of monoclonal antibodies
Provided is a use of a recombinant chimaeric protein as an immunogen in a process for producing a monoclonal antibody, wherein the recombinant chimaeric protein is assembled into a virus-like...
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7879326 |
Human neutralizing monoclonal antibodies to H5N1 influenza A virus
A panel of IgG1 human monoclonal antibodies (HMAbs) identified by hemagglutination inhibition (HI) assay has been produced from peripheral B cells of an individual immunized with prototype H5N1...
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7871621 |
Anti-HBs monoclonal antibody
An anti-HBs monoclonal antibody is described herein. This antibody can bind to the following: (i) a wild type HBsAg; (ii) at least one mutant HBsAg selected from the group consisting of a first...
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7867497 |
Monoclonal antibodies to respiratory syncytial virus and uses therefor
The present invention is directed to particular human monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of respiratory syncytial virus infections....
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7858752 |
Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant...
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7855277 |
Picornaviruses, vaccines and diagnostic kits
A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (I)...
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7811568 |
Smallpox monoclonal antibody
Humanized monoclonal antibodies against the vaccinia virus B5R surface antigen. The antibodies are effective in treating smallpox infection. Also disclosed are nucleic acids that encode the heavy...
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7807405 |
Glycoprotein synthesis and remodeling by enzymatic transglycosylation
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and...
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7786269 |
Antibody to latent membrane proteins and uses thereof
The present invention provides antibodies and antibody fragments directed against extracellular domains of the EBV LMP proteins, including LMP1, LMP2A and LMP2B. The invention also provides methods...
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7785592 |
Stabilized liquid anti-RSV antibody formulations
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which ...
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7740852 |
Binding molecules capable of neutralizing rabies virus and uses thereof
Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules,...
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7732132 |
Monoclonal antibody to the common epitope of NSs protein of watermelon silver mottle virus and assay for tospovirus
The invention is an assay for detection of Watermelon silver mottle virus (WSMoV)-serogroup tospoviruses using a monoclonal antibody and a method for preparing the monoclonal antibody. A hybridoma...
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7727529 |
Human monoclonal antibody Fab fragments directed against HCV E2 glycoprotein and endowed with in vitro neutralizing activity
The invention refers to a human antibody, or its functional fragments, directed against the HCV E2 glycoprotein, able to have a neutralizing activity in vivo; a composition for anti-HCV therapy...
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7728110 |
Antibodies to SARS coronavirus
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize...
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7718775 |
Monoclonal antibody with the capability of neutralizing enterovirus type 71 infection
The present invention provides a monoclonal antibody capable of neutralizing EV71 infection.
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7700735 |
High potency recombinant antibodies and method for producing them
High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for...
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7700726 |
HIV antisense proteins
Disclosed is a novel HIV gene comprising a set of open reading frames encoded with the template as the plus strand of the proviral DNA, and located in the region of HIV-1 long terminal repeat. The...
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7666420 |
Composition for treating pathology associated with MSRV/HERV-W
The inventive composition comprises at least one type of antibody selected in a group (i) of anti-Env-SU MSRV/HERV-W antibodies or in a group of anti-TLR4 antibodies specifically linkable with the...
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7635476 |
Anti-hepatitis a virus antibodies
Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also ...
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7632497 |
Engineering Fc Antibody regions to confer effector function
The present invention relates to molecules having a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region. These...
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7629443 |
Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus
The present invention provides an isolated antibody capable of binding to the receptor-binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV)...
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7622112 |
Anti-SARS monoclonal antibodies
Monoclonal antibody reagents that recognize the SARS-coronavirus (SARS-HCoV) are needed urgently. In this report we describe the development and immunochemical characterization of mAbs against the...
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7579446 |
Binding molecules capable of neutralizing rabies virus and uses thereof
The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding...
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RE40831 |
Human monoclonal antibodies to the hepatitis B surface antigen
Disclosed is a process for obtaining hybridoma cell lines which produce human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as the hybridoma cell lines,...
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7488477 |
Neutralizing monoclonal antibodies to respiratory syncytial virus
The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies,...
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7485430 |
Methods and compositions for evaluation of fertility
The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In...
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7482006 |
Recombinant enterovirus 71 neutralizing antibodies and applications thereof
Provided is an antibody against enterovirus 71 comprising the amino acid sequence shown in SEQ ID NOS: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 or functionally active homologues...
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7442497 |
Methods of determining chronic hepatitis C infection
Methods for determining chronic hepatitis C infection are provided by the present invention. The methods generally involve determining the optical density of fluid samples which have tested...
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7402561 |
Compositions and methods for inhibiting abnormal cell growth
In the US about ⅓ of college women show evidence of HPV infection. The clinical problem may be even larger in developing countries. There are currently no effective therapies for HPV infections, a...
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7396914 |
SARS nucleic acids, proteins, antibodies, and uses thereof
Codon-optimized nucleic acids, polypeptides, and antibodies are described herein.
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7364737 |
Human neutralizing monoclonal antibodies to respiratory syncytial virus
Human monoclonal antibodies and fragments thereof which bind, neutralize and provide passive immunotherapy to respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also...
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7345152 |
Monoclonal antibody specific for an epitope of inactivated feline immunodeficiency-encoded glycoprotein
The present invention provides a monoclonal antibody specific for an epitope which is unique to the surface protein component of an inactivated feline immunodeficiency virus (FIV) envelope...
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7314622 |
Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic...
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7311906 |
Anti-viral activity of an anti-thymidine kinase monoclonal antibody
Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating viral infection.
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7294703 |
PRO6093 Antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7276334 |
Construction and characterization of monoclonal antibodies against western equine encephalitis virus
Construction and characterization of mouse monoclonal antibodies against western equine encephalitis virus (WEE) for potential use in detection, diagnosis, and immunotherapy are disclosed....
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