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7378090 |
Alleviation of the memory deficits and memory components of psychiatric dysfunctions by altering atypical PKM activity
Methods have been developed for alleviating memory problems or psychiatric dysfunctions that have a memory formation component. These methods are based on the finding that a truncated form of an...
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7371828 |
Extracellular signal-regulated kinase sequences and methods of production and use
The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5...
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7368237 |
Cell death-related nucleases and their uses
An assay uses apoptotic nucleases to screen for apoptosis modulators, in a method of modulating apoptosis, and in a method of aiding in a diagnosis of a disease, among other methods. materials for...
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7361741 |
Antibody, or fragment thereof, capable of binding specifically to human pancreatic lipase
An antibody, or fragment thereof, capable of binding specifically to one or more human dietary enzymes, said antibody or fragment thereof comprising a heavy chain variable domain derived from an...
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7358352 |
Nucleic acids encoding human TNF-α convertase
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
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7355015 |
Matriptase, a serine protease and its applications
The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or...
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7339031 |
Modified bouganin proteins, cytotoxins and methods and uses thereof
The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The...
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7312321 |
Antibody to human enzymes of the metalloprotease family
This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in...
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7311906 |
Anti-viral activity of an anti-thymidine kinase monoclonal antibody
Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating viral infection.
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7309779 |
Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42
The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic...
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7297336 |
Factor IXa specific antibodies displaying factor VIIIa like activity
Ligands such as antibodies that can bind factor IX/factor IXa and increase the procoagulant activity of factor IXa (FIXa), pharmaceutical compositions containing such ligands, methods for treating...
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7294705 |
Anti-PRO3580 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7285643 |
Antibodies to novel murine and human kinases
The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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7279290 |
ATM kinase compositions and methods
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation...
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7279274 |
Method for diagnosing diabetes in a mammal
Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug...
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7276375 |
Monoclonal antibody recognizing phosphatidylinositol-3,4,5-triphosphate
A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4,5-triphosphate (PIP3) but does not cross-react with structurally similar phospholipid antigens is advantageous for...
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7273610 |
Endotheliase-2 ligands
Proteins that bind to ET2, such as immunoglobulins that inhibit ET2 with high affinity and selectivity, are provided. The ET2 binding proteins can be used to treat a variety of disorders, including...
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7264932 |
Nuclease inhibitor cocktail
Methods and compositions for inhibiting and/or inactivating nucleases by using nuclease inhibitors are provided. The nuclease inhibitors comprise anti-nuclease antibodies and non-antibody nuclease...
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7247442 |
Antibodies to HHPEN62 polypeptide
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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7235380 |
CDR-grafted anti-tissue factor antibodies and methods of use thereof
The present invention provides CDR-grafted antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced...
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7232661 |
Diagnostic agents for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing the same
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method,...
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7214373 |
Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
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7195926 |
Antibodies to a cathepsin C homolog
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for...
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7189823 |
Antibody against illfdyfnr
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and...
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7183110 |
Antibody immunoreactive with a 5-enolpyruvylshikimate-3-phosphate synthase
Genes encoding Class II EPSPS enzymes are disclosed. The genes are useful in producing transformed bacteria and plants which are tolerant to glyphosate herbicide. Class II EPSPS genes share little...
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7176291 |
Glycine N-methyltransferase monoclonal antibodies and methods of use therefor
The present invention provides two unique monoclonal antibodies directed against a portion of the human Glycine N-methyltransferase, and methods of use for the monoclonal antibodies in detecting,...
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7169759 |
Tetrapeptide inhibitors of β-secretase
Statine-derived peptide inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in...
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7169566 |
Metalloproteinases
The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins....
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7157237 |
Antibodies for enzymes of the ω-oxidation pathway and methods relating thereto
The present invention provides antigenic peptides useful for the production of antibodies which selectively bind to an enzyme involved in the ω-oxidation of fatty acids and alkanes to...
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7153941 |
Antibodies that bind PRO4994 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7148063 |
Mitochondrial creatine kinase antibody
The object of the present invention is to provide a method for more accurately assaying the enzyme activities of mCK isozymes and a method for separately assaying the enzyme activities of CK...
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7135555 |
Mammalian TNF-α convertases
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
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7115715 |
Anti-idiotype antibodies to MN proteins and MN polypeptides
Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for...
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7115382 |
Method for detecting IGFBP-4 protease without detecting IGFBP-4 protease/proMBP Complex
Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for...
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7112325 |
Antibodies to calcium independent cytosolic phospholipase A2/B enzymes
The invention provides a novel calcium-independent cytosolic phospholipase A 2 /B enzyme, polynucleotides encoding such enzyme, antibodies to such enzyme, and methods for screening unknown...
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7108992 |
ATM kinase compositions and methods
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation...
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7105330 |
Human plasma hyaluronidase
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7101680 |
Method for detecting the presence of monomeric brain associated human glutamine synthetase
A method for diagnosing Alzheimer's disease(AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically human glutamine synthetase, in bodily fluid,...
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7101675 |
Modulators of regulatory proteins
A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a...
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7094881 |
Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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7091323 |
Human TIMP-1 antibodies
Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute...
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7083786 |
MASP-2, a complement-fixing enzyme, and uses for it
The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease-2 (MASP-2), a new serine protease that acts in the MBLectin complement fixation pathway.
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7081519 |
Antibodies to serine protease polypeptides
Antibodies that specifically bind to novel serine protease polypeptides are disclosed. The polypeptides are selected from the group consisting of a polypeptide as shown in SEQ ID NO:2 from residue...
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7078491 |
Selective binding agents of telomerase
The present invention relates to novel selective binding agents including polyclonal and monoclonal antibodies that recognize and bind to the catalytic subunit of human telomerase (hTERT). The...
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7074903 |
Monoclonal antibody specific to tartrate-resistant acid phosphatase 5b and use thereof
Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to...
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7074554 |
Antibodies specific for NEBR1 and methods of use thereof
Materials and methods are provided to inhibit HIV replication in targeted host cells.
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7070945 |
Process for determining the presence of monomeric brain associated human glutamine synthetase in patients exhibiting mild cognitive impairment
A method for determining those patients suffering from mild cognitive impairment (MCI) who have a likelihood of progressing to Alzheimer's disease (AD) is disclosed. The method involves directly...
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7067113 |
Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
Screening methods for identifying compounds that bind to or activate (D 1 or D 5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in...
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7056718 |
Polypeptides having oxaloacetate hydrolase activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having oxaloacetate hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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7053188 |
Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase
Compositions and methods for diagnosis of neoplastic tissue are described. Monoclonal antibodies which specifically recognize the tumor cell specific NADH:protein thiol reductase and the hybridoma...
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