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7148063 |
Mitochondrial creatine kinase antibody
The object of the present invention is to provide a method for more accurately assaying the enzyme activities of mCK isozymes and a method for separately assaying the enzyme activities of CK...
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7135555 |
Mammalian TNF-α convertases
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
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7115382 |
Method for detecting IGFBP-4 protease without detecting IGFBP-4 protease/proMBP Complex
Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A) are described. Methods for...
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7115715 |
Anti-idiotype antibodies to MN proteins and MN polypeptides
Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for...
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7112325 |
Antibodies to calcium independent cytosolic phospholipase A2/B enzymes
The invention provides a novel calcium-independent cytosolic phospholipase A 2 /B enzyme, polynucleotides encoding such enzyme, antibodies to such enzyme, and methods for screening unknown...
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7108992 |
ATM kinase compositions and methods
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation...
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7105330 |
Human plasma hyaluronidase
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7101675 |
Modulators of regulatory proteins
A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a...
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7101680 |
Method for detecting the presence of monomeric brain associated human glutamine synthetase
A method for diagnosing Alzheimer's disease(AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically human glutamine synthetase, in bodily fluid,...
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7094881 |
Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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7091323 |
Human TIMP-1 antibodies
Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute...
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7083786 |
MASP-2, a complement-fixing enzyme, and uses for it
The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease-2 (MASP-2), a new serine protease that acts in the MBLectin complement fixation pathway.
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7081519 |
Antibodies to serine protease polypeptides
Antibodies that specifically bind to novel serine protease polypeptides are disclosed. The polypeptides are selected from the group consisting of a polypeptide as shown in SEQ ID NO:2 from residue...
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7078491 |
Selective binding agents of telomerase
The present invention relates to novel selective binding agents including polyclonal and monoclonal antibodies that recognize and bind to the catalytic subunit of human telomerase (hTERT). The...
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7074554 |
Antibodies specific for NEBR1 and methods of use thereof
Materials and methods are provided to inhibit HIV replication in targeted host cells.
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7074903 |
Monoclonal antibody specific to tartrate-resistant acid phosphatase 5b and use thereof
Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to...
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7070945 |
Process for determining the presence of monomeric brain associated human glutamine synthetase in patients exhibiting mild cognitive impairment
A method for determining those patients suffering from mild cognitive impairment (MCI) who have a likelihood of progressing to Alzheimer's disease (AD) is disclosed. The method involves directly...
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7067113 |
Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
Screening methods for identifying compounds that bind to or activate (D 1 or D 5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in...
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7056718 |
Polypeptides having oxaloacetate hydrolase activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having oxaloacetate hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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7053188 |
Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase
Compositions and methods for diagnosis of neoplastic tissue are described. Monoclonal antibodies which specifically recognize the tumor cell specific NADH:protein thiol reductase and the hybridoma...
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7052890 |
Transglutaminase gene products
The invention provides a nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 10 A, FIG. 6 B or FIG. 10 A or FIG. 10 B; nucleotides which hybridise to the...
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7048923 |
Antibodies to mitogenic oxygenases
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention...
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7049412 |
Antibodies to aggrecan-degrading metalloprotease and diagnostic methods using same
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu 373 -Ala 374 ....
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7049407 |
Heparanase specific antibodies and their use in research and medical applications
A variety of heparanase specific antibodies which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific...
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7026140 |
Serum paraoxonase
Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of...
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7015008 |
Antibodies for human cytochrome P450 2D6
The present invention features antibodies referred to herein as “MAb50-4” and “MAb184-10”, and polypeptides that compete with MAb50-4 and MAb184-10 for binding to CYP2D6. MAb50-4 can be...
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6951923 |
Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
This invention provides for antibodies directed to OLD-35 protein, the product of the OLD-35 gene, which displays enhanced expression during cellular senescence and terminal cell differentiation.
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6933369 |
Mammalian proteinases; oxidoreductases; related reagents
Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related...
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6893831 |
Immunoassay of PIVKA-II
The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing...
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6890721 |
Interleukin-1β converting enzyme like apoptotic protease-6
Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilize...
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6887705 |
Tyrosine phosphorylated cleavage furrow-associated proteins (PSTPIPs)
This invention concerns new PSTPIP polypeptides which are bound by and dephosphorylated by the PEST family of protein tyrosine phosphatases. The invention specifically concerns native murine PSTPIP...
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6878810 |
Zace1: a human metalloenzyme
Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the...
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6849450 |
Antibodies to the metalloproteinase inhibitor
A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders...
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6825000 |
Immunoassay reagent and immunoassay method
An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an...
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6822080 |
Human cyclin-dependent kinase-like proteins and methods of using the same
Substantially pure human cyclin-dependent kinase-like proteins PITALRE and PISSLRE and isolated protein complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that...
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6797812 |
Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use
The invention relates to an isolated nucleic acid molecule encoding a caspase-14 polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that...
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6790614 |
Selectable cell surface marker genes
The present invention concerns a method of identifying genetically modified mammalian cells using a mutated protein-tyrosine kinase receptor (PTKR) as a selectable marker in mammalian cells....
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6783986 |
Sucrose phosphate synthetase (SPS), a preparation method and cDNA therefor, and use of the cDNA for modifying SPS expression in plant cells
Proteins having the activity of saccharose phosphate synthetase (SPS) and a process for obtaining the same.
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6767540 |
Use of antagonists of plasminogen activator inhibitor-1 (PAI-1) for the treatment of asthma and chronic obstructive pulmonary disease
The invention relates to methods for treatment of asthma and chronic obstructive pulmonary disease (COPD) by administration of antagonists to plasminogen activator inhibitor type-1 (PAI-1)....
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6767997 |
Antibodies that bind deoxyribonuclease IIβ enzyme proteins
The present invention provides cDNAs encoding deoxyribonuclease IIβ and isolated, purified deoxyribonuclease IIβ proteins. Antibodies against this protein and antisense agents targeted to a cDNA...
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6759204 |
Method and kit for early diagnosis of cancer
The invention concerns a method for early diagnosis of cancer in a patient which consists in identifying by any appropriate method the presence of autoantibodies directed against the Csk protein in...
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6747134 |
Antibody immunologically reactive with serine protease EOS
Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized...
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6743897 |
Aspergillus fumigatus profilin
The invention provides isolated nucleic acid and amino acid sequences of A. fumigatus profilin, methods of screening for A. fumigatus profilin modulators using biologically active A. fumigatus...
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6740737 |
Cardiovascular system associated protein kinase 2 (CSAPK-2) antibodies
The invention provides isolated nucleic acids molecules, designated CSAPK nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules,...
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6733981 |
Antibodies to interleukin-1 β converting enzyme like apoptosis protease-3 and 4
Disclosed are human interlude-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by...
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6730488 |
Immunological materials and methods for detecting dihydropyrimidine dehydrogenase
Monoclonal antibodies against dihydropyrimidine dehydrogenase are disclosed. Immunologic assays using the monoclonal antibodies are also disclosed.
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6716960 |
Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use
The invention provides an isolated gene encoding Mch3, or functional fragment thereof. Also provided is an isolated nucleic acid sequence encoding Mch3 or functional fragment thereof. The gene or...
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6713060 |
Nek1-related protein kinase
The invention provides a human Nek1-related protein kinase (NRPK) and polynucleotides which identify and encode NRPK. The invention also provides expression vectors, host cells, antibodies,...
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6709653 |
Antibodies specific for human inositol monophosphatase H1
Human Inositol Monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for...
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6693175 |
Method for diagnosing bone dysbolism
A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. ...
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