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8168758 |
Anti-MN antibodies and methods of using same
The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder.
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8158762 |
Anti-factor B antibodies and their uses
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration...
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8147836 |
Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins
Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and...
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8142791 |
Multi-modal cancer therapy using viral hitch-hiking
The present invention relates to an antibody fusion protein which specifically recognizes the VA, HN or F surface antigen of the New Castle Disease Virus (NDV), a surface molecule of a...
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8124352 |
Methods and compositions for targeting HEPSIN
Anti-HEPSIN monoclonal antibodies, and methods for using the antibodies, are provided.
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8114968 |
Metalloproteinase-12 specific monoclonal antibody
Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described.
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8114606 |
ARL-1 specific antibodies
This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides...
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8106168 |
Metalloproteinase binding proteins
Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
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8071348 |
Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid...
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8048995 |
Human skeletal muscle-specific ubiquitin-conjugating enzyme
The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes...
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8048993 |
Heparanase specific molecular probes and their use in research and medical applications
According to the present invention there is provided an antibody that specifically binds an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in...
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8008452 |
Phosphorylated Ndr kinase
The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying...
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7994291 |
Human E3α ubiquitin ligase family
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, ...
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7989597 |
Immunogenic memapsin 2 β-secretase peptides and methods of use
This application pertains to antibodies which specifically bind to immunogenic memapsin 2β-secretase peptides for use in the treatment of Alzheimer's disease and memapsin 2β-secretase disorders. T...
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7977314 |
Methods and compositions to treat and detect misfolded-SOD1 mediated diseases
The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method...
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7973143 |
Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate...
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7973142 |
Antibodies that bind human protein tyrosine phosphatase beta (HPTPβ)
Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof.
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7960513 |
Antibody against a human ADAM protease
Elucidation of the crystal structure of an ADAM10 substrate-recognition and proteinase-positioning module comprising the protein cysteine-rich and disintegrin domains, and detailed functional...
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7939280 |
Marker for inflammatory conditions
Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
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7939282 |
Methods for detecting sepsis
Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the...
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7906297 |
Reagents for the detection of phosphorylated ATR kinase (Ser 428) and uses thereof
The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA...
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7902340 |
Antibodies binding to the extracellular domain of the receptor tyrosine kinase ALK
The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a...
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7846673 |
Soluble form of carbonic anhydrase IX (s-CA IX), assays to detect s-CA IX, CA IX'S coexpression with HER-2/neu/c-erbB-2, and CA IX-specific monoclonal antibodies to non-immunodominant epitopes
Disclosed herein is the discovery of a soluble MN/CA IX (s-CA IX) found in body fluids, such as, urine and serum. Soluble CA IX comprises the extracellular domain of CA IX or portions thereof. The...
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7829095 |
Inhibitory monoclonal antibody against blood clotting factor VII-activating protease
A monoclonal antibody which inhibits the blood clotting factor VII-activating protease and its proenzyme and a blood clotting factor VII-activating protease, stabilized by the addition of said...
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7824876 |
Method for diagnosing acute coronary syndrome
A bioaffinity assay for quantitative determination in a sample of free PAPP-A, defined as the pregnancy associated plasma protein A (PAPP-A) that is not complexed to the proform of major basic...
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7824682 |
Cardiac myosin light chain kinase-specific antibodies and methods of detecting
The present disclosure provides a cDNA, protein sequence, and genomic structure of the human cardiac isoform of myosin light chain kinase (cMLCK), and describes mutations in the cMLCK gene that are...
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7820797 |
Glycolipopeptide antibodies
A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal...
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7816499 |
Antibodies that selectively bind HDAC9
The present invention features, inter alia, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide comprising the amino acid sequence as set forth in...
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7799326 |
Methods and compositions for cathespin k complex-mediated disorders
Methods and compositions for the amelioration of symptoms mediated by the collagenolytic activity of cathepsin K complex are provided. Methods of specifically modulating the collagenolytic activity...
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7771960 |
Feline pancreatic lipase
Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic...
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7759466 |
Monoclonal antibodies to alpha-amylase
Monoclonal antibody that specifically binds to alpha-amylase and is useful for detecting weather damage (i.e. pre-harvest sprouting) in cereal grain.
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7745588 |
Antibodies to a paralytic peptide
The invention relates to a low molecular weight peptide (or suite of related peptides) isolated from the submaxillary saliva glands of shrews of the species Blarina as a paralytic agent. This novel...
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7745586 |
Human E3α ubiquitin ligase family
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, ...
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7745587 |
Antibodies that bind MMP-14
Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
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7722875 |
Antibodies that bind canine pancreatic lipase
Isolated nucleic acid molecules having a nucleotide sequence encoding canine pancreatic lipase polypeptides, allelic variants and fragments thereof. Vectors and host cells containing the...
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7723049 |
Marker for inflammatory conditions
Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
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7718777 |
MHC-peptide complex binding ligands
Disclosed are protein ligands comprising an immunoglobulin heavy chain variable (VH) domain and an immunoglobulin light chain variable (VL) domain, wherein the proteins bind a complex comprising an...
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7662929 |
Antibody that specifically binds hyaluronan synthase
Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the...
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7662769 |
Glycosyltransferase GnT-V having neovascularization action
The present invention provides a peptide or protein having a neovascularization action and containing a basic amino acid cluster region of β1,6-N-acetylglucosaminyltransferase, a ...
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7601816 |
Antibodies to cyclooxygenase variants
The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring...
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7579002 |
Method for improving body weight uniformity and increasing carcass yield in animals
A method for improving animal body weight uniformity or for increasing animal carcass yield is disclosed. The method involves administering an agent to one or a group of animals wherein the agent...
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7579447 |
Antibodies against LLG polypeptides of the triacylglycerol lipase family
Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the...
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7569674 |
Autophilic antibodies
Antibodies having noncovalent, autophilic properties are disclosed. The autophilic antibodies are derived from antibodies conjugated with an autophilic peptide. Such autophilic antibodies can...
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7569669 |
Calcium independent cytosolic phospholipase A2/B enzymes
The invention provides a novel calcium-independent cytosolic phospholipase A2/B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory...
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7550569 |
Antibodies that specifically bind to GMAD
The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and...
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7541330 |
Conjugates with reduced adverse systemic effects
A conjugate of an active agent and a targeting moiety having affinity for a target cell, in which the active agent has been modified by attachment of a cell membrane-impermeabilizing group so that,...
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7541159 |
Molecular-specific urokinase antibodies
Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of...
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7537762 |
Human monoclonal antibodies to activin receptor-like kinase-1
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and...
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7534433 |
Method for improving body weight gain and feed conversion efficiency in animals
A method for improving body weight gain and increasing feed conversion efficiency of in animals by feeding the animals a diet containing antibodies against anti-nutritional factors in food.
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