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5928904 |
DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
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5925351 |
Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
This invention relates to compositions and methods comprising "lymphotoxin-β receptor blocking agents", which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are...
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5925352 |
Method of treating inflammation with antibodies to neutrophil chemotactic factor
An isloated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA...
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5922847 |
Methods of purifying hematopoietic cells using an antibody to a stem cell factor receptor
The present invention relates to monoclonal antibodies specific for a cell receptor specific for human stem cell factor (hSCF) as well as pharmaceutical compositions containing such monoclonal...
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5919452 |
Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
Treatment of tumor necrosis factor, TNF, mediated pathologies is provided by administering anti-TNF compounds, such as anti-TNF antibodies and anti-TNF peptides, which compounds are specific for...
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5919911 |
Monoclonal antibodies to stem cell factor receptors
The present invention relates to monoclonal antibodies specific for a cell receptor specific for human stem cell factor (hSCF) as well as pharmaceutical compositions containing such monoclonal...
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5919912 |
Mammalian IAP antibodies and diagnostic kits
Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to...
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5916561 |
Monoclonal antibody against CD44v6
The invention concerns an antibody active against an epitope coded by the exon v6 variant of the CD44 gene. The antibody concerned has characteristics superior to those of prior art antibodies and...
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5914110 |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
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5911988 |
Method for treating asthma using SCF antibody
This invention provides pharmaceutical compositions comprising anti-SCF antibodies for the reduction of eosinophila in the lungs of mammals. This invention also provides for methods of treating...
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5912136 |
Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4.
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5911987 |
Cell surface protein and effector cell bonding reagent
The present invention relates to a bonding reagent, which is characterized in that it comprises a first bonding component specific for the hemagglutinin-neuraminidase molecule of a Newcastle...
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5907033 |
Anti-oncostatin M monoclonal antibodies
The present invention relates to monoclonal antibodies that define Oncostatin M, a novel cytokine. The monoclonal antibodies of the invention are capable of binding to Oncostatin M, inhibiting...
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5891644 |
Antibody specific for an isolated chemotactic factor from patients with endometriosis
A composition comprising a soluble peptide of about 23 kD to about 29 kD, capable of causing neutrophil and macrophage chemotaxis, and which is substantially similar to chemotactic factor from...
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5891722 |
Antibodies to free IGFBP-1
Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and...
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5888510 |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
Methods for inhibiting synovial cell growth and treating chronic rheumatoid arthritis are provided. The methods comprise administering a pharmaceutical composition comprising an interleukin-6...
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5888511 |
Treatment of autoimmune diseases, including AIDS
The present disclosure concerns the treatment of a patient with autoimmune disease, including AIDS, by neutralizing, removing or inhibiting different types of interferons, tumor necrosis factor,...
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5888705 |
Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells ex vivo
A method of inducing the proliferation and/or differentiation of human adult pancreatic cells entails contacting primary cultures of such cells with Hepatocyte Growth Factor/Scatter Factor...
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5874080 |
Anti-IL-8 monoclonal antibodies for treatment of asthma
Methods are provided for the treatment of asthma with anti-IL-8 monoclonal antibodies.
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5872221 |
Antibody having binding specificity to parathyroid hormone related protein (PTHrP) and kit comprising the same
Antibody reagents capable of binding epitopes of PTHrP and a kit for the detection of PTHrP or fragments thereof comprising one or more antibody reagents capable of binding to epitopes of PTHrP.
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5866689 |
Monoclonal antibodies to GP130 protein
Monoclonal antibodies recognizing gp130 protein and binding to the protein to inhibit IL-6 functions completely (that is to the same level as that is the absence of IL-6) when present in enough...
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5863537 |
Humanized monoclonal antibodies against human interleukin-4
Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal...
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5853697 |
Methods of treating established colitis using antibodies against IL-12
The present invention provides a method for treating the inflammatory response of an established colitis in a subject with inflammatory bowel disease (IBD), comprising administering to a subject...
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5851525 |
Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
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5846536 |
Restoration of normal phenotype in cancer cells
A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying β 1 integrin function-blocking antibody to the cells. The method can be used...
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5831032 |
Interleukin-8 anti-peptide antibodies
Polypeptide analogs, antibodies, diagnostic and therapeutic compositions as well as methods for detecting the presence of IL-8 and preventing the inflammatory response in patients are described.
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5830469 |
Fas antagonists and uses thereof
The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of...
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5798213 |
Monoclonal antibodies
The present invention provides monoclonal antibodies against peptides having an amino acid sequence described in Sequence No. 1 or No. 2, the peptides being found in human thymidine phosphorylase...
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5798229 |
Bispecific molecules recognizing lymphocyte antigen CD2 and tumor antigens
The present invention relates to novel and highly effective bispecific antibody fragments which recognize lymphocyte CD2 antigen and any variable tumor antigen. Moreover, the invention relates to...
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5798274 |
Method for selecting monoclonal antibodies for human G-CSF permitting low-level detection in human fluids
The present invention relates to a high affinity monoclonal antibody for human G-CSF and to an enzyme immunoassay using said antibody. Specifically, the practice of the invention permits one...
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5795967 |
Tumor necrosis factor antagonists and their use
Tumor necrosis factor antagonists are administered in therapeutically effective doses to suppress inflammatory immune-potentiated events. The antagonists of this invention typically are selected...
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5789185 |
Selective immunoassay for IL-1β
The subject invention concerns a novel selective, sensitive, and highly reliable immunoassay for detecting human IL-1β in cultured mononuclear cells or human body fluids. It is a sandwich...
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5783184 |
Method for treatment and diagnosis of IL-5 mediated disorders
The present invention relates to treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs and other altered antibodies such as Fabs,...
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5780597 |
Monoclonal antibodies to cytotoxic lymphocyte maturation factor
The present invention relates to antibodies which bind to a novel cytotoxic lymphocyte maturation factor. When bound to the cytotoxic lymphocyte maturation factor, the antibodies can neutralize...
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5777085 |
Humanized antibodies reactive with GPIIB/IIIA
Humanized immunoglobulins specifically reactive with GPIIb/IIIa proteins are prepared employing recombinant DNA technology for use in, e.g., treatment of various thrombosis-related disorders.
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5767240 |
Activity-dependent neurotrophic factor
The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increase the survival of spinal cord neuron cells, cerebral cortical cells and...
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5763195 |
Method and compositions for making ACSF and ACSF antagonists
The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid...
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5762923 |
Stabilized interferon alpha solutions
An aqueous interferon composition which comprises an amount of interferon-alpha dissolved in water with a non-ionic detergent and benzyl alcohol in amounts sufficient to stabilize the amount of...
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5760186 |
Antibody to macrophage-derived inflammatory mediator (MIP-1α and MIP-1β)
Antibodies to an inflammatory cytokine are disclosed. The inflammatory cytokine has been isolated from cells that have been incubated with a stimulator material and comprises a protein that is...
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5756342 |
BCRF1 antagonists for treating epstein-barr virus infections
A method of treating EBV infections is provided. The method comprises administering an effective amount of an monoclonal antibody antagonist to the EBV protein, BCRF1. Preferably, the antagonist is...
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5730976 |
Method for treating macrophage pathogen infections by TGF-B antagonists
There is disclosed a method of treating a mammal infected with a macrophage pathogen comprising administering an effective amount of a TGF-β antagonist. Macrophage pathogens include any pathogenic...
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5728813 |
Antibodies directed against elk ligand
Antibodies to elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface...
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5723582 |
Antigen-specific human glycosylation inhibiting factor
The present invention provides antigen-specific human glycosylation inhibiting factor (GIF), Hybridoma cell lines ATCC HB 10473 and 11052 are provided as exemplary cell lines which produce human...
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5717074 |
Macrophage-derived inflammatory mediator (MIP-2)
An antibody to an inflammatory cytokine is disclosed. The inflammatory cytokine has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine is...
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5714585 |
Antibodies that are immunoreactive with interleukin-7
Antibodies that are immunoreactive with interleukin-7 (IL-7) proteins are provided. The anti-IL-7 antibodies may be polyclonal or monoclonal. Certain embodiments are directed to antibodies that are...
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5707621 |
Supression of nephritis-induced protein excretion by anti-IL-8
A method for ameliorating at least one of the symptoms of nephritis is disclosed. Administration of antibodies or immunologically reactive fragments thereof which are immunoreactive with the IL-8...
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5707622 |
Methods for treating ulcerative colitis
Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
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5705615 |
Antibodies specific for HT.sub.m4
The invention relates to a recombinant DNA molecule which encodes a HT m4 protein, a transformed host cell which has been stably transfected with a DNA molecule which encodes a HT m4 protein and...
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5702705 |
Antibody methods for the treatment of a hormone-mediated disease
Cleavage site blocking antibody that binds to prohormones, preferable Tumor Necrosis Factor, thereby preventing the formation of prohormone fragment(s) by proteolysis of the prohormone, and uses of...
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5702946 |
Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders
Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
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