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7431927 |
TNFα-neutralizing antibodies
The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from...
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7432360 |
Multi-dose erythropoietin formulations
The present invention is directed to multi-dose erythropoietin formulations for parenteral administrations. The formulations contain one or more of the following preservatives benzethonium...
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7427471 |
Modified “S” antibodies
The invention relates to the field of antibodies, and particularly to modified antibodies, methods of preparing modified antibodies and uses thereof. More particularly, the invention relates to the...
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7425330 |
Methods of inhibiting TNFα activity in the blood of a patient
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7423129 |
Antibodies to human eotaxin
The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or...
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7416729 |
Methods of treating rheumatoid arthritis with anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7411049 |
Hybridoma cell lines and monoclonal antibodies recognizing Prox1
Monoclonal antibodies to Prox1 of vertebrates (pfam05044.5; NM_002763.3) and two continuous cell lines for their production are disclosed. These antibodies are particularly useful in immunoassays...
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7405277 |
Antibodies against monocyte chemotactic proteins
The invention provides antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides cells producing the...
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7405274 |
Connective tissue growth factor antibodies
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention...
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7404955 |
Methods of inhibiting or neutralizing TNFα in patients with tissue injury
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7402662 |
Antibody molecules specific to human tumor necrosis factor alpha
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein...
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7396911 |
Chimeric polypeptides containing chemokine domains
This invention provides a chimeric DNA molecule comprising a sequence encoding a chemokine polypeptide covalently attached to a heterologous polypeptide, the encoded chimeric polypeptide, and uses...
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7390491 |
Agents comprising midkine or an inhibitor thereof as active ingredient
Midkine (MK), which is a retinoic acid-inducible heparin-binding growth factor, enhances neutrophilic migration and exists in an inflammatory state at a high concentration. The midkine or its...
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7390490 |
Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine
There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there...
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7387776 |
Human monoclonal antibodies against CD30
Isolated human monoclonal antibodies which bind to CD30 (e.g., human CD30) are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of...
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7381801 |
Chimerized GM-CSF antibodies
Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically...
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7371825 |
Anti-MCP-1 antibodies, compositions, methods and uses
The present invention relates to at least one novel anti-MCP-1 antibodies, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic...
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7371377 |
Antibodies to polypeptides homologous to VEGF and BMP1
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor...
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7371383 |
Recombinant anti-interleukin-9 antibodies
The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat...
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7368111 |
Human antibodies specific for TGFβ2
Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGFβ) bind specifically isoforms TGFβ2 and TGFβ1 or both,...
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7364865 |
Antibodies to myeloid progenitor inhibitory factor-1 (MPIF-1)
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3...
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7361474 |
Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer
The present invention provides methods for detecting, diagnosing or prognosticating prostate cancer by measuring the levels of macrophage migration inhibitory factor (MIF) in the serum of an...
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7354584 |
Recombinant IL-9 antibodies
The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and...
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7355014 |
Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use
A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-γ inducing polypeptide or active...
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7342110 |
Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced...
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7329737 |
Antibodies that bind hK-1
The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.
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7317089 |
Antagonistic anti-hTNFSF13b human antibodies
Human monoclonal antibodies that specifically bind to TNFSF13 b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13 b (e.g., K D =10 −8 M or less), a slow off rate for...
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7314722 |
Cytostatin II antibodies and methods
The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the...
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7312320 |
Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not...
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7307152 |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7300916 |
Preventives/remedies for thickened scar, keloid or chronic arthritic diseases
A pharmaceutical preparation for preventing and/or treating hypertrophic scars, keloid or chronic arthritic diseases comprising as an effective component an erythropoietin antagonist. More...
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7288250 |
Monoclonal antibodies against HMGB1
In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting...
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7285642 |
Composition and method for modulating dendritic cell-T cell interaction
The present invention relates to the use of a compound that binds to a C-type lectin on the surface of a dendritic cell, in the preparation of a composition for modulating, in particular reducing,...
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7285269 |
Antibodies directed to tumor necrosis factor
Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid...
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7279559 |
Antibodies that bind to interleukin-22
Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
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7276239 |
Recombinant A2-specific TNFα-specific antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7273609 |
Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
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7270816 |
IL-1-like cytokine antibodies
Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided....
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7265211 |
Anti-IL-TIF antibodies and methods of making
The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes...
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7264801 |
EG-VEGF nucleic acids and polypeptides and method of use
The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells...
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7261893 |
Neutralizing antibodies against GDF-8 and uses therefor
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in...
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7259244 |
Human homologue of the DBF4/ASK1 protein, nucleic acids, and methods related to the same
The present invention provides a human polypeptide homolog of DBF4/ASK1 (for “Activator of S phase kinase”) and polynucleotides which identify and encode DRF1 (for “DBF4 Related Factor 1”)....
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7253264 |
Immunoglobulin fusion proteins, their production and use
The invention relates to genetically engineered soluble fusion proteins composed of human proteins not belonging to the immunoglobulin family, or of parts thereof, and of various portions of the...
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7253265 |
Antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1
An antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1.
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7250276 |
Human IL-1 epsilon DNA and polypeptides
The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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7250165 |
Anti-TNF antibodies, compositions, methods and uses
The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or...
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7247711 |
IL-23p40 specific antibody
Novel anti-IL-23p40 specific human Ig derived proteins, including, without limitation, antibodies, fusion proteins, and mimetibodies, isolated nucleic acids that encode the anti-IL-23p40 Ig derived...
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7241576 |
Uses of THANK, a TNF homologue that activates apoptosis
The present invention is directed to the applications of a novel cytokine, named THANK, for TNF homologue that activates apoptosis, NF-κB and c-jun N-terminal kinase. Such applications include...
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7226593 |
Methods of treating cachexia with chimeric anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α(TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7227003 |
Anti-TNF antibody fragments
Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as...
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