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8952133 Nonviral vectors for delivering polynucleotides to target tissue  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
8927691 Transducible polypeptides for modifying metabolism  
Methods and compositions for modifying the metabolism of a subject are provided. One embodiment provides a recombinant polypeptide having a polynucleotide-binding domain, a protein transduction...
8895701 Peptide-conjugated oligonucleotide therapeutic and method of making and using same  
Conjugates for the efficient delivery of sequence-specific antisense to cells of a selected type for the inhibition of a target protein have the general formula: peptide-HBL-antisense in which the...
8592645 Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis  
The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene...
8541550 Methods and compositions for delivering polynucleotides  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
8507277 Nonviral vectors for delivering polynucleotides  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
8133733 Nonviral vectors for delivering polynucleotides to target tissues  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
8088897 Assay method for group transfer reactions  
An isolated antibody produced against a donor product of an enzymatically catalyzed group transfer reaction is disclosed. In one aspect, the antibody has the ability to preferentially recognize...
8076461 Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids  
An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or...
8062891 Nonviral vectors for delivering polynucleotides to plants  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
8039587 Methods and compositions for delivering polynucleotides  
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein...
7893016 Stabilisation of double-stranded nucleic acids using proteins  
A composition for treating a nucleic acid duplex, wherein the composition is capable of inhibiting denaturation of the duplex, characterised in that the composition comprises a ubiquitin-like...
7838637 Single-chain multiple antigen-binding molecule, its preparation and use  
The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the...
7799327 Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment  
This invention describes a method whereby human autoimmune antibodies are used as carrier compounds to deliver imaging agents and pharmaceutical drugs to the tumor in the human patient. These...
7771972 Gene cluster of pederin biosynthesis genes  
The present invention relates to the cloning, sequencing and analysing of a gene cluster encoding a modular polyketide synthase enzyme involved in the biosynthesis of the antitumor compound...
7569390 Selection of intracellular immunoglobulins  
A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This...
7537932 Antibodies that bind purified mammalian FLT3 ligands  
Flt3 ligand from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said ligand. Methods of using said reagents and diagnostic kits are...
7432346 Gene expressed in prostate cancer  
A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety...
7399589 Immunological detection of RNA:DNA hybrids on microarrays  
The present invention provides a hybridization method and kit for the detection and measurement of biological molecules. A test sample containing the biological molecules of interest is hybridized...
7378505 Assay method for group transfer reactions  
The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer...
7378091 Antibodies against carbonic anhydrase IX (CA IX) tumor antigen  
The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the...
7368293 Liver enriched transcription factor  
HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes...
7071311 Antibodies having specificity for 2′-C-allyl nucleic acids  
The present invention relates to antibodies, antibody conjugates, and compositions thereof, methods of antibody synthesis, and applications of antibodies useful for detecting the presence of...
7037894 Stabilized proteins  
Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or...
6998229 Glucuronide repressors and uses thereof  
Clones containing a sequence encoding a glucuronide repressor are described. The nucleotide and amino acid sequences of a repressor (gusR) are presented. A glucuronide repressor is used to control...
6927035 Antiuracil monoclonal antibody  
A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying...
6905860 Artificial chromosome  
An artificial mammalian chromosome, more specifically, a clone containing a mammalian centromere sequence and a DNA replication origin with mammalian telomere sequences added to both ends of the...
6723548 DNA repair polypeptides and methods of use  
The present invention provides polypeptides having pyrimidine glycosylase activity, preferably, pyrimidine glycosylase/AP lyase activity. The polypeptides include a targeting sequence, preferably...
6653103 Inhibition of nucleocytoplasmic transport by vesicular stomatitis virus M protein-like polypeptides  
A fragment of vesicular stomatitis virus (VSV) matrix protein (M protein) and M proteins of other viral species that can inhibit nucleocytoplasmic transport of RNA, proteins and RNA-protein...
6608034 Immunovectors for the intracellular and intranuclear transport  
A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into...
6537566 Compositions and methods for the non-invasive treatment of uterine fibroid cells  
The proliferation of uterine fibroid leiomyoma cells is inhibited by certain Fibroid Cell Growth Inhibitor (FGI) agents. The pharmacological doses of these FGI agents in the milieu of uterine...
6503736 Antibodies to crosslinkers and methods for using the same  
The present invention is directed to the discovery of antibodies that will react to proteins or nucleic acids bound to particular crosslinkers, but not to the free crosslinkers or free proteins or...
6399748 In-vitro method for prognosticating the illness development of patients with carcinoma of the breast and/or for diagnosing carcinoma of the breast  
The present invention is directed to a method of prognosticating the illness development of patients with carcinoma of the breast and/or for diagnosing carcinoma of the breast, the method...
6358711 Antibody to human testin and methods of making and using  
The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists....
6355609 Methods for stabilizing liquid nutritional products and products so stabilized  
Nutritional solutions and methods of making same are disclosed. The solutions include protein, lipid, and a carbohydrate source including high amylose starch and guar gum.
6183121 Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets  
The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an...
6057097 Marker for pathologies comprising an auto-immune reaction and/or for inflammatory diseases  
The present invention comprises a marker for inflammatory diseases and/or pathologies comprising an autoimmune reaction, which is the plasmatic membrane and/or a portion therof, in particular the...
6001657 Antibodies that selectively bind quadruplex nucleic acids  
Antibodies that selectively bind to quadruplex nucleic acids are described. Isolated cells that produce such antibodies, and methods utilizing these antibodies, are also described.
5993818 Use of autoantibodies for tumor therapy and prophylaxis  
A method of inhibiting the growth of a tumor cell in a mammal by administering to the mammal an autoantibody, e.g, an antinuclear autoantibody from an aged mammal, that binds to either one or both...
5811247 Monoclonal antibodies to nucleolar protein  
The invention relates to a hybridoma cell line which produces a monoclonal antibody which cross reacts with both yeast and human fibrillarin. Diagnostic kits are also described. These are useful...
5756684 Cloning and expression of PUR protein  
The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. Inhibitors of PUR activity may be used to...
5721341 Derivatives of nucleosides, processes for the production of these derivatives of nucleosides and specific polyclonal and monoclonal antibodies of these derivatives  
The invention relates to derivatives of nucleosides, processes for the production of these derivatives of nucleosides, as well as specific polyclonal and monoclonal antibodies of the...
5691137 Methods of screening candidate agents for biological activity using yeast cells  
Methods of identifying and screening for agents with biological activity against target molecules using yeast cell cultures are described.
5612458 Antibody to PNA/nucleic acid complexes  
This invention relates to antibodies to complexes formed between PNA (Peptide Nucleic Acid) and nucleic acids, particularly antibodies to PNA/DNA or PNA/RNA complexes. The preferred antibodies are...
5589341 Origin of replication complex genes and methods of using the same  
Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening...
5221609 Molecular genetic probe, and method of forming same, assay technique and kit using said molecular genetic probe  
A method of assaying for the presence or quantity of a suspect nucleic acid in a suspect sample using a modified genetic probe in combination with an imaging procedure. The probe is modified by...
5221611 ddI immunoassays, derivatives, conjugates and antibodies  
This invention relates to a method for the immunoassay of ddI (2',3'-dideoxyinosine), also known as didanosine, in biological fluids such as serum, semen, plasma and urine, as well as other body...
5210077 Antibodies to cytokinins having a glycosylated isoprenoid side chain and immunoassay methods  
Antibodies (polyclonal and monoclonal) having specificity for cytokinins having a glycosylated isoprenoid side chain are described. The antibodies simultaneously recognize a purine ring, an...
5192683 Monoclonal antibodies to cruciform DNA structure  
The present invention relates to monoclonal antibodies of class IgG1 and IgM possessing among others the property to bind to stable heteroduplex cruciform DNA structures constructed from two DNA...
5053336 Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use  
Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when...

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