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7390489 |
Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody
The present invention relates to a monoclonal antibody binding specifically to the p60 protein of Listeria monocytogenes , a hybridoma cell producing the monoclonal antibody, a test kit comprising...
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7388080 |
Selective inhibition of toll-like receptor-2
It has been found that Toll-like receptor 1 and Toll-like receptor 2 (TLR2) physically interact. Antibodies that specifically bind to TLR2 and selectively inhibit induction of cytokines are also...
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7385038 |
Non-natural labeled amino acid and method of constructing amino acid/tRNA complex
This invention relates to: a labeled amino acid that can be introduced into a protein with the aid of a protein synthesis system; a functional protein having functions derived from a label...
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7381802 |
Human antibodies that specifically recognize the toxin Cn2 from Centruroides noxius scorpion venom
The present invention is directed to recombinant human antibodies specific for Cn2 toxin from C. noxius scorpion venom. The antibodies are able to recognize the toxin and preferably neutralize it...
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7375194 |
Antibodies that bind to an epitope on the Huntington's disease protein
The present invention relates generally to the generation and characterization of anti-huntingtin antibodies binding an epitope on the Huntington's disease protein. The invention further relates to...
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7371382 |
Methods of inhibiting αvβ3-mediated binding with αvβ3-specific antibodies
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to α V β 3 , or a functional fragment thereof. The invention also provides nucleic acid molecules...
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7368256 |
Antibodies against Stachybotrys chartarum and methods for their use
Antibodies to various fungal antigens are disclosed, including monoclonal antibody 9B4 that selectively binds an antigen of Stachybotrys chartarum spores not found in Stachybotrys chartarum ...
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7364737 |
Human neutralizing monoclonal antibodies to respiratory syncytial virus
Human monoclonal antibodies and fragments thereof which bind, neutralize and provide passive immunotherapy to respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also...
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7361345 |
Anti-CD40 antibodies capable of blocking B-cell activation
Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen...
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7361344 |
Co-administration of a thrombolytic and an-anti-CD18 antibody in stroke
A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective...
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7355013 |
PRO6017 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7355009 |
Antibodies to human Elk, a voltage-gated potassium channel subunit
The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and...
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7354586 |
Methods of treating arthritis and diabetic retinopathy with αvβ3-specific antibodies
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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7348406 |
Metabolic gene polynucleotides and polypeptides and uses thereof
The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GMG-3, GMG-4, Cluster 1, GMG-6A,...
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7344848 |
Methods for determining adequacy of heat processing of a cooked meat sample
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7338660 |
Methods of treating cancer and enhancing immune responses with antibodies that bind CD40
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7335744 |
Prostate cancer specific internalizing human antibodies
This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The...
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7329738 |
Assays for detection of Bacillus anthracis
This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis . The methods are based on the discovery of binding agents, including recombinant polyclonal...
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7329406 |
Methods of treating psoriasis with αvβ3-specific antibodies
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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7326577 |
Cell fixation and use in phospho-proteome screening
A new method of cell fixation using a mild denaturing heat and the fixative PERMIFLOW™ or similar fixative that preserves cell morphology, light scatter profiles, nucleic acid content, cell...
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7323331 |
Method for detecting or assaying HBV
A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody...
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7323170 |
Anti-CD80 antibodies
The present invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from...
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7320873 |
Use of antibodies against specific MHC-peptide complexes
The invention describes a method to diagnose the autoimmune disease activity by detecting the presence of an autoimmune specific MHC-peptide complex in a patient suffering from an autoimmune...
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7312320 |
Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not...
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7311910 |
Methods for treating cancer and infectious disease by blocking CTLA4-B7 interactions
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing...
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7306800 |
Treatment of autoimmune disorders with antibodies to costimulating polypeptide of T cells
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against the 8F4 molecule and hybridoma cells which produce the monoclonal...
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7288638 |
Fully human antibodies against human 4-1BB
Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody....
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7288634 |
Isolated antibodies immunoreactive with synthetic peptides used to detect rheumatoid arthritis
The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The...
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7288252 |
Methods of therapy for B-cell malignancies using antagonist anti-CD40 antibodies
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment...
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7288251 |
Antibodies to CD40
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7285642 |
Composition and method for modulating dendritic cell-T cell interaction
The present invention relates to the use of a compound that binds to a C-type lectin on the surface of a dendritic cell, in the preparation of a composition for modulating, in particular reducing,...
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7282205 |
Anti-hepatitis A virus antibodies
Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also...
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7276588 |
Antibody of human mitochondrial voltage dependent anion channel
An isolated antibody that binds to a plasminogen kringle 5 receptor, i.e., the human voltage-dependent anion channel, preferably at an epitope between amino acids Tyr 224 through Lys 255 thereof,...
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7268219 |
Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means
A complex comprising an HLA Class 1 molecule and attaching means for selectively attaching the HLA class 1 molecule to a target cell is disclosed, and a method is provided for producing or...
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7262278 |
Anti-HLA-DR antibody
This invention provides an anti-HLA-DR monoclonal antibody. This invention relates to an antibody binding to HLA-DR or a functional fragment thereof having (a) life-extending effects in nonhuman...
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7262272 |
Polypeptide compositions formed using a coiled-coil template and methods of use
The invention relates to the use of constrained coiled-coil polypeptides to mimic α-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or...
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7259247 |
Anti-human T-cell costimulating polypeptide monoclonal antibodies
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the...
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7250492 |
Compositions and methods for inhibition of cancer invasion and angiogenesis
The invention provides antibodies that specifically bind a membrane protease complex, the complex consisting of two homodimers of seprase and dipeptidyl peptidase IV (DPPIV), obtained from...
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7250167 |
Method of treatment with anti-CD2 antibody LO-CD2b
A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when...
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7244574 |
Method of assaying lupus anticoagulant and assay reagent
A monoclonal antibody having inhibitory activity on blood coagulation reactions, which reacts with prothrombin forming a complex with phosphatidylserine but does not react with prothrombin not...
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7235380 |
CDR-grafted anti-tissue factor antibodies and methods of use thereof
The present invention provides CDR-grafted antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced...
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7235372 |
Use of neuronal apoptosis inhibitor protein (NAIP)
The invention provides a novel NAIP nucleic and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
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7230087 |
P. aeruginosa mucoid exopolysaccharide specific binding peptides
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for...
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7227004 |
Antibodies to vascular endothelial cell growth factor
The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related...
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7227003 |
Anti-TNF antibody fragments
Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as...
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7226593 |
Methods of treating cachexia with chimeric anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α(TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7223549 |
Compositions for identification and isolation of stem cells
The invention provides monoclonal antibodies that selectively bind to ectodermally- and endodermally-derived stem cells and methods for the diagnosis of a neoplasm in a subject by contacting a...
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7223396 |
Methods of treatment of fistulas in Crohn's disease with anti-TNF antibodies
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7220839 |
Antibody recognizing proliferative human liver cells, proliferative human liver cells and functional human liver cells
The invention provides a monoclonal antibody which specifically recognizes proliferative human hepatocytes, a method for isolating proliferative human hepatocytes by using the antibody, and a...
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7217795 |
Tumor suppressor designated TS10q23.3
A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene...
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