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7635476 |
Anti-hepatitis a virus antibodies
Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also...
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7625561 |
Diabody which specifically binds Streptococcus surface antigen I/II and methods of use thereof
Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody...
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7618783 |
Anthrax specific antibodies
The present invention is directed to diagnostic tools and therapies using antibodies to Bacillus anthracis. Specifically, the present invention is directed to a B. anthracis -specific monoclonal...
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7618633 |
Antibodies that bind CD40 and methods of treating cancer and enhancing immune responses
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7611708 |
Methods of therapy for B-cell malignancies using antagonist anti-CD40 antibodies
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7604800 |
Anti-PSGL-1 antibodies
Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of...
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7598351 |
Antibody and use thereof
The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2...
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7595051 |
Methods of treating neovascular glaucoma, macular degeneration and capillary proliferation with alphavbeta3-specific antibodies
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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7592006 |
Composition comprising the LO-CD2a antibody
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
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7592007 |
Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA-4 specific antibodies
Isolated ligands which bind a molecule expressed on the surface of T cells and induce antigen specific apoptosis in activated T cells are disclosed. Preferably, the T cell surface molecule is CTLA4...
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7585501 |
Compositions and methods for treating kidney disease
The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to...
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7585671 |
Hedgehog interacting proteins and uses related thereto
The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to...
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7582736 |
Prostate cancer specific internalizing human antibodies
This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The...
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7563442 |
Antibodies to CD40 and methods of treating cancer and enhancing immune responses
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7563443 |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential...
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7563441 |
Anti-P-selectin antibodies
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind...
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7560242 |
Metadherin polypeptides, encoding nucleic acids and methods of use
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the...
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7547438 |
CD40-binding activating antibodies
Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance...
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7541033 |
Humanized anti-IL-1β antibodies
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof,...
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7538196 |
Bispecific antibody molecule
A first bispecific antibody molecule comprises at least one binding site with a variable domain on a light chain (V L ) and a variable domain for the T-cell receptor CD-28, linked thereto on a...
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7537763 |
Anti-CD40 monoclonal antibody
An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40.
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7534605 |
CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable...
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7531643 |
Monoclonal antibody inducing apoptosis
The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having...
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7531175 |
Methods for modulation of immune responses using humanized immunoglobulins reactive with B7-1 molecules
The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The...
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7528104 |
Peptides that bind to the erythropoietin receptor
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7510712 |
Methods of treating rheumatoid arthritis with 7C10 and 16C10 CD80-specific antibodies
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
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7510713 |
Methods of inducing immunosuppression by administering 7C10 and 16C10 CD80-specific antibodies
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
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7510711 |
Methods for the treatment of cancer using anti-CD40 antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the...
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7507797 |
Single-chain antibody acting against 37 kDa/67 kDa Iaminin receptor as tools for the diagnosis and therapy of prion diseases and cancer, production and use thereof
Single-chain antibodies are described which specifically recognize both the 37 kDa precursor form of the laminin receptor (37 kDa LRP) and the 67 kDa high-affinity form of the laminin receptor (67...
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7507793 |
Mammalian sweet taste receptors t1r3
The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of...
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7501124 |
Methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which...
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7498032 |
Methods for treating immune disorders or cancer with anti-CD40 antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the...
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7494651 |
TGF-β binding antibodies
The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are...
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7491393 |
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
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7488477 |
Neutralizing monoclonal antibodies to respiratory syncytial virus
The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies,...
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7488807 |
Antibody with protein A selectivity
Monoclonal antibodies, and antigen binding fragments thereof, which bind to Protein A of Staphylococcus aureus are provided.
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7482433 |
Peptides and compounds that bind to the IL-5 receptor
Interleukin-5 receptor (IL-5R) ligands comprising amino sequences of formula TGGGDGYVX 3 VEX 4 ARCPTCK, EGYVX 3 VEX 4 ARCPTCK, EGYVX 3 VEX 4 ARCPTCR, GYVX 3 VEX 4 ARCPTCG, EGYVX 3 VEX 4 ARCPTCG,...
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7482003 |
Treatment for asthma with α4-specific antibodies
The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific...
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7482007 |
Methods of inhibiting angiogenesis to treat cancer with alphavbeta3-specific antibodies
The present invention describes methods for inhibition angiogenesis in tissues using vitronectin α v β 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in...
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7479544 |
Anti-PRO87299 antibodies
The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
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7476385 |
Methods of inhibiting IgE responses to thymus-dependent antigens with the anti-gp39 antibody MR1
Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which...
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7473564 |
Kit and method for detecting the ESM-1 protein
The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising:
a) a first antibody specifically binding to the N-terminal region of protein ESM-1 contained between...
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7468256 |
Tools for detecting Moraxella catarrhalis
The present invention provides compositions and methods useful for detecting Moraxella catarrhalis . The compositions are antibodies, proteins or nucleic acid sequences specific to Moraxella...
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7465446 |
Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.
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7465445 |
Methods of preventing or treating graft versus host reaction by administering an antibody or portion thereof that binds to AILIM
An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and...
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7465444 |
Methods of suppressing or treating an inflammatory bowel disease by administering an antibody or portion thereof that binds to AILIM
Antibodies against AILIM (also called ICOS and 8F4) were found to significantly suppress the onset of inflammatory bowel diseases (especially Crohn's disease and colitis (ulcerative colitis and...
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7465464 |
Populations of cells that express flk-2 receptors
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also...
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7459539 |
Antibody that binds zinc transporter protein 108P5H8
A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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