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6210671 |
Humanized antibodies reactive with L-selectin
Humanized immunoglobulins specifically reactive with L-selectin are prepared employing recombinant DNA technology for use in e.g., treatment of inflammatory disorders.
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6211341 |
Polypeptide having factor Xa inhibitory activity
The present invention provides an antibody which specifically reacts with an epitope of a polypeptide comprising the amino acid sequence X-Y-CYS GLN GLU GLU GLU CYS PRO ASP PRO TYR LEU CYS SER PRO...
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6207156 |
Specific antibodies and antibody fragments
The present invention relates to methods and products for immunotherapy resulting in the stimulation of T-cell proliferation. The products of the invention are peptides that bind to CTLA-4 and...
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6200559 |
Use of antibodies against MxA or MxB to determine levels of type I interferons in vivo
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6201107 |
Cystic fibrosis gene
The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier...
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6187549 |
Protein as a diagnostic of cancer
The presence of A-protein in an abnormally large amount in a sample, such as blood, from an individual is diagnostic of primary or metastatic cancer in the individual. The presence of A-protein is...
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6180370 |
Humanized immunoglobulins and methods of making the same
Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor...
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6180762 |
Glycyrrhetinic-acid-like factor
A human glycyrrhetinic-acid-like factor which inhibits certain enzymes in pathways of steroid hormone degradation is disclosed.
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6180102 |
Monoclonal antibody to human Mx protein MxA
This invention provides a monoclonal antibody which recognizes an epitope corresponding to amino acids 10 to 220, amino acids 221 to 297, or amino acids 469 to 662, counting from the N-terminus of...
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6177547 |
Antibodies to P-selectin glycoprotein ligand
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [ 3 ...
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6171588 |
Anti-αvβ3 integrin antibody antagonists
Monoclonal antibodies that recognize the α v β 3 integrin receptor complex, but do not significantly bind to α IIb β IIIa , inhibit α v β 3 integrin-mediated diseases.
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6165784 |
Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies
Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals, and postmortem detection...
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6165464 |
Monoclonal antibodies directed to the HER2 receptor
A method of inhibiting growth of tumor cells which overexpress a growth factor receptor or growth factor by treatment of the cells with antibodies which inhibit the growth factor receptor function,...
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6162902 |
Human BNP-specific antibodies
The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes...
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6156882 |
Antibody 4G8B4B12
The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as...
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6156519 |
(➝)-β- d-glucan binding protein, an antibody recognizing the protein and use thereof
A (1➝3)-β-D-glucan binding protein obtainable by affinity chromatography or gel filtration of an extract of horseshoe crab amoebocytes and having a molecular weight of about 580 kDa, as...
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6139839 |
Control of infectious microorganisms by modulation of chorionic gonadotropin-related protein activity
A method of controlling, in a warm-blooded animal, an infectious microorganism expressing a chorionic gonadotropin-like growth-regulating protein comprises modulating the activity of the protein by...
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6140470 |
Human monoclonal anti-tumor antibodies
Human monoclonal anti-tumor antibodies are isolated from fusion phage single-chain Fv and V H antibody libraries constructed from the peripheral blood lymphocytes of immunized cancer patients....
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6140485 |
Nucleic acid encoding human neuronal calcium channel subunits
Nucleic acids encoding each of three subunits, α1B, α2δ, and β3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells...
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6132722 |
Recombinant antibody-enzyme fusion proteins
The invention is related to recombinantly produced fusion polypeptides comprising antibody V H and V L sequences operatively linked to a β-lactamase for use in the delivery of cytotoxic drugs to...
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6123915 |
Methods for using agents that bind to VCAM-1
A therapeutic method of modulating the immune response, by administering to a patient an amount of IL-4 effective to promote peripheral blood lymphocyte adhesion to microvascular endothelial cells...
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6123939 |
Anti-neoplastic drugs in cancer therapy
This invention is directed toward novel synergistic combinations of ligand-mimicking agents specific to the c-erbB-2 protein and anti-neoplastic drugs or agents, which can be used to treat a...
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6120766 |
CDW52-specific antibody for treatment of multiple sclerosis
The invention relates to the use of an antibody recognizing the Cdw52 antigen in the treatment of multiple sclerosis. Preferably, the antibody is the humanized antibody in the humanized antibody...
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6117981 |
Hybridomas for lung cancer marker and monoclonal antibodies thereof
Hybridomas secreting monoclonal antibodies specific for an epitope found in the amino acids of LCGA associated with non-small cell lung carcinoma protein have been found. The monoclonal antibodies...
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RE36866 |
Anti-aids immunotoxins
The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptase. Also...
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6113901 |
Methods of stimulating or enhancing the immune system with anti-CD3 antibodies
Disclosed are immunopotentiating agents, and vaccines thereof, which enhance and/or otherwise modify immune responses, and methods for their preparation and use in vivo. Immunopotentiating agents...
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6103879 |
Bivalent molecules that form an activating complex with an erythropoietin receptor
Antibodies and Bivalent molecules which activate erythropoietins and induce the proliferation or differentiation of erythroid progenitor cells are provided. Also provided are methods of using such...
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6096311 |
Methods for use of monoclonal antibodies specific for the high affinity Fc receptor for immunoglobulin G
Monoclonal antibodies which react specifically to Fc receptor of human effector cells are disclosed. Binding of the antibodies to the receptor is not blocked by human immunoglobulin G. The...
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6090923 |
Murine monoclonal antibody binding TNFα
A cytotoxic protein expressed by human peripheral blood mononuclear cells is isolated in essentially homogenous form. This protein may be used to elicit production of polyclonal or monoclonal...
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6086879 |
Antibody to the syncytiotrophoblast antigen R80K and use thereof
This invention relates to a method for suppressing the cytotoxic activity of mammalian Natural Killer (NK) cells, especially in women experiencing repeated miscarriages. An antibody which binds to...
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6087113 |
Monoclonal antibodies for human mesenchymal stem cells
The invention relates to isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i e. mesenchymal stem cells or "MSCs"), and...
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6074833 |
Osteoblast and fibroblast antigen and antibodies recognizing it
Monoclonal antibodies (MAb) are provided which have binding specificity to an antigen expressed on osteogenic and fibroblastic cells (OFA) and are capable of binding to osteogenic and fibroblastic...
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6071517 |
Bispecific heteroantibodies with dual effector functions
Bispecific molecules which react both with the high-affinity Fcγ receptor of human effector cells and with a target cell surface antigen are disclosed. Binding of the molecules to the Fc receptors...
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6071519 |
Immunotoxins specific for CD86 expressing cells
An immunotoxin molecule comprising an antibody specific for human CD 86 antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof, wherein the binding...
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6068840 |
Recombinant CDR-grafted and chimeric anti-IL-8 antibodies containing CDRs or the variable region from the mouse monoclonal antibody, WS-4
Monoclonal antibodies immunospecific for the neutrophil chemotactic factor, IL-8, have been humanized by reshaping the variable regions to conform more closely to human counterparts. These...
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6063906 |
Antibodies to integrin alpha subunit
The present invention relates to antibodies that bind to a highly charged region of the integrin α E subunit and its functional equivalents. The antibodies are useful in screening assays to...
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6063620 |
Type I angiotensin II receptor specific monoclonal antibodies and hybridomas
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6060309 |
Immune mediators and related methods
A method for preparing a responder cell clone that proliferates when combined with a selected antigenic peptide presented by a stimulator cell is disclosed. CD56 negative, CD8 negative responder...
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6056959 |
CD40 antigen antibody complex
Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen...
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6054561 |
Antigen-binding sites of antibody molecules specific for cancer antigens
Novel compositions are provided that are derived from antigen-binding sites of immunoglobulins having affinity for cancer antigens. The compositions exhibit immunological binding properties of...
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6051230 |
Compositions for targeting the vasculature of solid tumors
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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6040148 |
Corynebacterial stress proteins
The present invention relates to a purified stress protein of 86 Kd and fragments thereof isolated from the genus Corynebacterium. Particular fragments include those with apparent molecular weights...
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6037453 |
Immunoglobulin variants
Two classes of polypeptides derived from human IgE are described. One class binds selectively to the high affinity IgE receptor on mast cells and basophils, but not to the low affinity IgE receptor...
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6033667 |
Method for detecting the presence of P-selectin
The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes...
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6030614 |
Ameliorating immunological rejection of allograft
The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a...
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6024936 |
Antibody-based method of localizing activated thrombin receptors
The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at...
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6025477 |
Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
This invention provides purified antigens which are indicative of the presence of atherosclerotic plaque. Different concentrations of these antigens have been found to coincide with the progression...
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6022541 |
Immunological preparation for concurrent specific binding to spatially exposed regions of vascular permeability factor bound in-vivo to a tumor associated blood vessel
The present invention provides an immunological preparation comprising not less than two types of conjugate molecules in admixture for concurrent specific binding to a spatially exposed region of...
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6020306 |
Receptor-type tyrosine kinase and use thereof
The present invention relates to an isolated receptor-type tyrosine kinase. The receptor-type tyrosine, in its naturally occurring form, is characterized by being reactive to monoclonal antibody...
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6020170 |
Method of preparing a monoclonal antibody
The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only...
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