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6559286 |
Antibodies to occludin proteins
The present invention discloses antibodies that bind to mammalian occludin proteins which are transmembrane adhesion molecules of the tight junction. Nucleic acid and amino acid sequences encoding...
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6555111 |
Method of inhibiting the cytocidal effect of TNF with TNF receptor-specific antibodies
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF...
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6552170 |
PEGylation reagents and compounds formed therewith
Compounds are disclosed having the general formula R 1 -X-R 2 , wherein R 1 and R 2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R 1...
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6551599 |
Monoclonal antibodies against campylobacter jejuni and campylobacter coli outer membrane antigens
The present invention is directed to a method of producing monoclonal antibodies that are highly specific for (1) unique epitopes of Campylobacter jejuni (Cj) only and (2) epitopes conserved...
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6545130 |
Monoclonal antibodies to mycobacterium tuberculosis and a modified ELISA assay
The present invention provides for monoclonal antibodies, the hybridoma cell lines which produce these antibodies, and the use of such monoclonal antibodies in the detection of M. tuberculosis. ...
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6545128 |
Anti-bax inhibitor protein antibodies
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
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6541214 |
N-terminally truncated HER-2/neu protein as a cancer prognostic indicator
There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western...
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6541206 |
Objective biochemical method for assessment of sperm quality
A method of testing sperm quality including obtaining a sample of sperm to be tested; detecting and measuring the testis-specific HspA2 chaperone protein (or, the chaperone protein homologues to...
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6541611 |
LO-CD2b antibody
A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when...
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6537550 |
Use of avian antibodies
The present invention relates to use of avian antibodies and/or antigen binding fragments thereof, for the production of a drug for treatment and/or prevention of respiratory tract infection. The...
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6538108 |
Compositions and methods relating to DNA mismatch repair genes
Genomic sequences of human mismatch repair genes and gene products are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing...
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6534058 |
Anti-C5 monoclonal antibodies
The invention relates to C5 inhibitors, which inhibit type II endothelial cell activation, wherein the inhibition is manifested by the suppression of E-selectin. These inhibitors are useful in...
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6534057 |
Method increasing the delayed-type hypersensitivity response by infusing LFA-1-specific antibodies
Methods for treating and inhibiting disease and symptoms associated with the human immunodeficiency virus (HIV) are provided. The method includes transforming the human immunodeficiency virus (HIV)...
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6528061 |
Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a...
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6528625 |
Anti-CCR5 antibodies and kits comprising same
The present invention relates to an antibody or functional portion thereof which binds to a mammalian (e.g., human) chemokine receptor 5 protein (CKR-5 or CCR5) or portion of the receptor. The...
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6525180 |
Antibodies to mammalian T cell surface antigen
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided....
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6511665 |
Antibodies to interleukin-1 receptors
The present invention provides monoclonal antibodies and binding proteins which specifically bind to the IL-1 receptor. Also provided are methods for detecting IL-1 receptors on cells, and for...
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6511664 |
Intercellular adhesion molecule—2 and its binding ligands
The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as...
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6506383 |
Methods of suppressing immune responses to transplanted tissues and organs with gp39-specific antibodies
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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6506382 |
Method for inhibiting reperfusion injury using antibodies to P-selectin glycoprotein ligand
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [ 3...
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6503755 |
Particle transfection: rapid and efficient transfer of polynucleotide molecules into cells
A rapid, simple method of directly transfecting a large number of eukaryotic, prokaryotic or plant cells, which retains substantial cell viability is achieved by the present invention. The method...
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6503509 |
Method for receptor desensitization
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell...
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6498237 |
Tumor necrosis factor antibodies
The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is...
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6488930 |
Anti-CCR4 antibodies and methods of use therefor
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding...
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6489448 |
Antiparasitic helminth larval thiol specific antioxidant-antibodies, and uses thereof
The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA...
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6489126 |
Method of identifying cells expressing a protein having pre-B cell growth-supporting ability
A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability, and a novel membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell...
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6485970 |
Immunointeractive antibody
The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to...
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6482926 |
Antibody compositions for preparing enriched cell preparations
The present invention relates to antibody composition that are useful in preparing enriched cell preparations such as human hematopoietic progenitor cells and stem cells and non-hematopoietic tumor...
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6479247 |
Dendritic cell-specific antibodies
Isolated antibody or preparation of antibodies comprising an antigen-binding domain wherein the antigen is present on activated dendritic cells and wherein the antibody does not interact with...
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6479640 |
Antibody specific for a protein tyrosine phosphatase that localizes to focal adhesions
An antibody is provided that is specific for a PTPH1 protein, a phosphatase that dephosphorylates phosphotyrosine residues in phosphoproteins having tyrosyl residues that are phosphorylated by...
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6472511 |
Stimulation of an immune response with antibodies labeled with the α-galactosyl epitope
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using an antibody that binds with an epitope of an antigen that is associated with a tumor or...
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6468531 |
Method of promoting cellular function
The present invention relates, in general, to a method of producing a therapeutic effect and, in particular, to a method of using antibodies to promote cellular function, to antibodies suitable for...
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6458934 |
Humanized antibody specific for human 4-1BB
The present invention is directed to humanized antibodies that specifically bind the protein 4-1BB. The antibodies can be made by grafting of the complementarity determining regions (CDR's) of...
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6455044 |
5c8 antigen
This invention provides for an isolated protein specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916. This invention also provides for an...
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6451979 |
Methods of treatment using NBS-1, antibodies and proteins thereto, and uses of the antibodies
Antibodies that will specifically bind to NBS-1 are described. It is also shown that NBS-1 will interact with p53 responsive elements in a p53 promoter. Thus, NBS-1 can be used in subjects having a...
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6451310 |
Method for inhibiting an allergic response with a 5c8-specific antibody
This invention provides a method of inhibiting an allergic response in a subject by inhibiting T cell activation of B cells, wherein said method comprises administering to the subject an antibody...
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6451981 |
Antibodies against lymphocyte-associated cell surface protein LAM-1
Human lymphocyte-associated cell surface protein LAM-1, which includes domains homologous with binding domains of animal lectins, growth factors, and C3/C4 binding proteins, and the cDNA encoding...
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6451982 |
Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy...
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6448379 |
IL8 inhibitors
Inhibitors, including antibodies, of IL8 binding to its receptors, that interact with the amino-terminal extracellular domain of the IL8 receptor and which compete with IL8 for receptor-binding,...
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6440733 |
Monoclonal antibodies recognizing antigens on the surface of endothelial cells of tumor vessel
A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing said monoclonal antibody,...
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6440416 |
Vaccines against cancer and infectious diseases
A method of stimulating an immune response in a human against malignant cells or an infectious agent comprises the step of administering to the human an immunogenic amount of a primate...
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6440418 |
Methods of treating autoimmune diseases with gp39-specific antibodies
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune...
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6440417 |
Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments
Antibodies to a therapeutic agent and its derivatives and conjugates are disclosed, including antibodies to argatroban and its derivatives and conjugates. The antibodies are useful as reagents in...
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6441139 |
Agents and method for identifying insects
The present invention provides an isolated immunoreactive molecule (IRM) capable of binding to a target molecule from at least one species or sub-species of the insect but not to at least one other...
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6432404 |
Methods of inhibiting locomotor damage following spinal cord injury with α D-specific antibodies
Methods to treat spinal cord injury using α d monoclonal antibodies are disclosed.
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6423500 |
Mammalian receptors for interleukin-10
Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified...
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6419925 |
Toxoplasma gondii antigens, the preparation thereof and the use thereof
The present invention relates to the identification of toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared....
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6413514 |
Methods of using antibodies against human CD40
A method for the treatment of T cell mediated disorders is described. The method involves administering to a subject a therapeutically effective amount of an anti-human CD40 antibody. Disease...
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6407214 |
Antibodies against E-selectin
This invention relates to whole antibodies of neutral isotype having specificity for E-selection, process for their preparation (using vectors), pharmaceutical compositions containing them, and...
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6399301 |
Human phospholipase A2 protein
The invention provides a human phospholipase A2 protein PHPLA2 and polynucleotides which identify and encode PHPLA2. The invention also provides expression vectors, host cells, agonists, antibodies...
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