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8183346 |
Anti-ferroportin 1 monoclonal antibodies and uses thereof
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of...
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8184000 |
Personal radio location system
Methods and apparatus for using an energy emanating device to find a person (17a,b) or an object based on preselected attributes (33) stored in the energy emanating device (10) are disclosed. A...
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8163286 |
Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are...
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8163885 |
Humanized antibodies against human interferon-alpha
The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ...
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8158759 |
Compositions and methods relating to glucagon receptor antibodies
The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure...
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8153765 |
Anti-CD38 antibodies for the treatment of cancer
Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of...
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8133982 |
FcγRIIB specific antibodies and methods of use thereof
The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention en...
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8128932 |
Anti-VEGFR monoclonal antibody, method of making and uses thereof
The subject invention is directed to a VEGFR2 (vascular endothelial growth factor receptor II) monoclonal antibody (mAb), and the amino acid sequence of the heavy chain and the light chain of the...
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8124093 |
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a...
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8105595 |
Methods of using neutralizing anti-TLR4/MD2 antibodies
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not...
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8097428 |
Monoclonal antibodies and their use
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof....
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8092804 |
Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
Binding members, especially antibody molecules, for interleukin (IL)-4 receptor alpha (IL-4Rα), and their therapeutic use e.g. in treating or preventing disorders associated with IL-4Rα, IL-4 a...
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8093360 |
Antibodies that bind B. anthracis exotoxin, formulations thereof, and methods of use
The present invention provides an antibody which binds to B. anthracis with toxin, formulations for administration of such antibodies intramuscularly, and methods of administering such antibodies...
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8088383 |
Methods of therapy for B-cell malignancies using antagonist anti-CD40 antibodies
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment...
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8084031 |
Method for the treatment of inflammatory disorders
A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable...
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8080638 |
Anti-interferon alpha monoclonal antibodies and methods for use
The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFNα”) protein subtypes for the prot...
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8080245 |
Anti-pathogen immunoadhesins
Chimeric molecules that include a pathogen recognition module derived from a pathogen binding domain of a pathogen recognition protein, e.g., a toll-like receptor (TLR), CD14, BPI, MD-2, scavenger...
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8071372 |
Tumor endothelial marker 5α molecules and uses thereof
The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host c...
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8071096 |
Anti-C5aR antibodies and uses thereof
The present invention relates to antibodies which bind to C5aR and which are useful in diagnostic and therapeutic methods. The antibodies of the present invention are reactive with an extracellular...
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8067002 |
Humanized anti-factor D antibodies
The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the...
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8058400 |
Composition and method for modulating dendritic cell-t cell interaction
The present invention relates to the use of a compound that binds to a C-type lectin on the surface of a dendritic cell, in the preparation of a composition for modulating, in particular reducing,...
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8038997 |
Anti-marinobufagenin antibodies and methods for their use
Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen...
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8039226 |
Anti NC1 monoclonal antibody
The present invention dedicates to detect nephritis in early stage of either primary or secondary nephritis using an anti NC1 monoclonal antibody. The present invention dedicates to provide useful...
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8034607 |
Methods of enhanced heterologous protein secretion
A method of enhancing heterologous protein secretion in a yeast cell is disclosed. In one embodiment, the method comprising the steps of engineering a yeast cell to overexpress at last one gene...
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8030025 |
Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and/or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs...
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8030454 |
Anti-hedgehog antibodies
The invention relates to anti-hedgehog antibodies, their use in the detection of hedgehog expression in tissue, and to the use of such detection in the treatment of cancer.
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8003764 |
Folliculin-specific antibodies and methods of detection
The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and antibodies that specifically bind to the BHD protein (folliculin). In addition, the present ...
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7999081 |
Anti-C5 alpha antibodies
The present invention refers to recombinant antibodies of human origin specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5...
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7999082 |
Anti-factor B antibodies
Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway...
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7988971 |
Human monoclonal antibodies against Hendra and Nipah viruses
The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah...
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7988964 |
NOGO-a neutralising immunoglobulin for treatment of neurological diseases
The present invention provides immunoglobulins, particularly antibodies that bind to NOGO and neutralise the activity thereof, polynucleotides encoding such antibodies, pharmaceutical formulations...
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7982016 |
Antigen binding proteins capable of binding thymic stromal lymphopoietin
The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular...
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7981628 |
Monoclonal antibodies and their use
Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof....
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7977461 |
Anti-platelet membrane glycoprotein VI monoclonal antibody
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI...
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7960518 |
Human binding molecules having killing activity against enterococci and uses thereof
The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding...
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7955599 |
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralising antibodies which are specific for human cytomegalovirus and bind with high affinity as well as immortalised B cells that produce such antibodies. The invention...
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7947808 |
Toxin detection method
According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the...
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7947274 |
Human cytomegalovirus neutralising antibodies and use thereof
The invention relates to neutralizing antibodies and antibody fragments having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for a combination of...
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7947809 |
Compositions and methods relating to glucagon receptor antibodies
The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure...
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7943334 |
Method of detecting allergen
The present invention provides an immunological detection method that can detect milk allergens, allergens of albumen, flour, buckwheat and peanut with high sensitivity in foods containing these...
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7943327 |
Simultaneous assay of target and target-drug binding
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding...
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7939073 |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
B-cell malignancies, such as the B-cell subtype of non-Hodgkin's lymphoma and chronic lymphocytic leukemia, are significant contributors to cancer mortality. The response of B-cell malignancies to...
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7932047 |
Method for detecting neoplastic disorders in a solubilized body sample
The present invention relates to a method for the early diagnosis of neoplastic disorders such as cancers as well as their precursor stages, particularly cancers of the respiratory tract, the...
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7928204 |
Spore specific antigen
The invention relates to a Bacillus spore specific antigen. Compositions and methods relating to the antigen are provided along with antibodies against the antigen. The antigen is specific for...
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7927593 |
TGF-beta binding antibodies
The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are us...
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7927595 |
Methods for downregulating CCR5 in T cells with anti-CD3 antibodies and anti-CD28 antibodies
Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for...
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7927596 |
Methods of antagonizing binding of CD40 to CD40L with CD40L-specific monovalent polypeptides
The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential...
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7919255 |
Assessment of skeletal growth using measurements of NT-CNP peptides
A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further...
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7915389 |
Anti-acharan sulfate antibody and its application
An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody...
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7897149 |
Fully human anti-VAP-1 monoclonal antibodies
Novel fully human anti-VAP-1 antibodies and fragments thereof are disclosed. Nucleic acids encoding anti-VAP-1 antibodies or fragments thereof, as well as expression vectors and host cells...
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