|
Match
|
Document |
Document Title |
|
|
7217799 |
Antibodies that recognize the 85P1B3 protein useful in treatment and detection of cancer
A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
|
|
|
7214373 |
Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
|
|
|
7211255 |
Contraceptives based on SP22 and SP22 antibodies
Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.
|
|
|
7211256 |
Plasmodium falciparum antigens inducing protective antibodies
The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein...
|
|
|
7208152 |
Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine receptor Bonzo (also referred to as STRL33, TYMSTR, HBMBU14 and CXCR6) and blocks the...
|
|
|
7205381 |
Mammalian cytokines; related reagents and methods
Nucleic acids encoding mammalian, e.g., rodent, IL-1δ, IL-1ε, purified IL-1δ and IL-1ε proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
|
|
|
7205390 |
Enzyme
A substantially pure 3-phosphoinositide dependent protein kinase that phosphorylates and activates protein kinase Bα. A recombinant polynucleotide encoding a protein kinase as defined. Uses of the...
|
|
|
7205391 |
Antibodies to a polypeptide suppressed in stomach tumors
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7202347 |
Antibodies to ELF-3 protein
Early developing stage-specific liver proteins and the genes coding for them that have been isolated and sequenced are provided, and these genes and proteins can be utilized to diagnose and/or...
|
|
|
7202345 |
PRO 1384 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7198789 |
Methods and compositions for modulating interleukin-21 receptor activity
Methods and compositions for modulating interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using agonists or antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed....
|
|
|
7199225 |
Human extracellular matrix-1
A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing...
|
|
|
7195926 |
Antibodies to a cathepsin C homolog
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for...
|
|
|
7196175 |
Antibodies to JTT-1 protein and cells secreting such antibodies
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have...
|
|
|
7193059 |
Antibodies that recognize a polypeptide overexpressed in rectal tumors
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7192583 |
Methods for modulating bone mineralization
Antibodies to a novel family of TGF-β binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases...
|
|
|
7193051 |
Histidine phosphatase interacting protein with 240kD
PHPIP-240 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PHPIP-240 polypeptides and...
|
|
|
7192711 |
Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders
Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in...
|
|
|
7193060 |
Antibodies to a polypeptides encoded by a nucleic acid overexpressed in kidney tumor and underexpressed in lung tumor
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7189823 |
Antibody against illfdyfnr
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and...
|
|
|
7179606 |
IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
|
|
|
7179610 |
Complement C3 precursor biopolymer markers indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
|
|
|
7169759 |
Tetrapeptide inhibitors of β-secretase
Statine-derived peptide inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in...
|
|
|
7169904 |
Immunocytokine sequences and uses thereof
The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified...
|
|
|
7166285 |
Anti-IL-12 antibodies and compositions
The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods...
|
|
|
7164007 |
Anti-PR020044 antibodies
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or...
|
|
|
7160990 |
Antibodies to a fibrinogen binding protein of staphylococcus epidermidis
A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding...
|
|
|
7160869 |
Biologically active metal-containing nucleic acids
The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal...
|
|
|
7160989 |
Antibodies that recognize and bind phosphorylated human androgen receptor and methods of using same
A phosphorylation site-specific antibody that recognizes phosphorylated serine 213 within the N-terminus of the androgen receptor was obtained which can be used in methods for determining the...
|
|
|
7157237 |
Antibodies for enzymes of the ω-oxidation pathway and methods relating thereto
The present invention provides antigenic peptides useful for the production of antibodies which selectively bind to an enzyme involved in the ω-oxidation of fatty acids and alkanes to...
|
|
|
7157085 |
Method for treating IgE-mediated disorders
The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which...
|
|
|
7153941 |
Antibodies that bind PRO4994 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7153666 |
Methods and compositions for determination of glycated proteins
This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits...
|
|
|
7151166 |
Antibody to mammalian cytokine-like polypeptide-10
A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and...
|
|
|
7148023 |
Immunoglobulin E detection in mammalian species
The present invention provides antibodies (e.g., monoclonal antibodies) that specifically binds to mammalian IgE (e.g., dog IgE). In some embodiments the antibodies bind to an epitope between amino...
|
|
|
7148330 |
Binding compounds for IL-27
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are...
|
|
|
7148331 |
Isolated human dehydrogenases, nucleic acid molecules encoding these human dehydrogenases, and uses thereof
The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the dehydrogenase polypeptides of the present invention. The present invention...
|
|
|
7144731 |
SCF antibody compositions and methods of using the same
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
|
|
|
7144990 |
Antibody to a polypeptide overexpressed in tumors
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7138498 |
Antibodies to MCP-4
Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods...
|
|
|
7138502 |
Antibodies to the propeptide of Candida albicans and methods of use
Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing...
|
|
|
7138508 |
Inhibitor protein of the wnt signal pathway
The present invention relates to an inhibitor protein of the wnt signal path, a DNA encoding such a protein and a process for the preparation of such a protein. In addition, this invention concerns...
|
|
|
7138499 |
Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the proteins of the present invention. The present invention specifically provides...
|
|
|
7138246 |
Methods for identifying or screening for agents that modulate 17β-HSD3
Methods for determining whether a test agent inhibits a 17β-HSD3, the methods comprising: obtaining a recombinant host cell that expresses the 17β-HSD3; obtaining a reaction mixture comprising...
|
|
|
7138501 |
Antibodies that immunospecifically bind BLyS
The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for...
|
|
|
7138496 |
Human monoclonal antibodies against human CXCR4
Compositions are provided that comprise antibody against membrane proteins such as chemokine receptors. In particular, monoclonal human antibodies against human CXCR4 are provided that are capable...
|
|
|
7135555 |
Mammalian TNF-α convertases
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and...
|
|
|
7135182 |
Inhibition of transglutaminase-mediated microbial interaction with a mammalian host
The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit...
|
|
|
7132099 |
Methods of modulating T lymphocyte costimulation with an antibody to an 8F4 polypeptide
A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the...
|
|
|
7129054 |
Antibodies to a growth/differentiation factor of the TGF-β family
The invention relates to an antibody or antibody fragment which specifically binds to a protein of the TGF-β family. The invention also relates to a kit for detecting a protein of the TGF-β...
|