|
Match
|
Document |
Document Title |
|
|
6211341 |
Polypeptide having factor Xa inhibitory activity
The present invention provides an antibody which specifically reacts with an epitope of a polypeptide comprising the amino acid sequence X-Y-CYS GLN GLU GLU GLU CYS PRO ASP PRO TYR LEU CYS SER PRO...
|
|
|
6207452 |
Antibody of the anti-proliferation domain of human Bcl-2
A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2....
|
|
|
6207804 |
Genetically engineered antibody analogues and fusion proteins thereof
Disclosed are a family of synthetic proteins having affinity for a preselected antigen. The proteins are characterized by one or more sequences of amino acids constituting a region which behaves as...
|
|
|
6203995 |
Agouti-related transcript antibodies and methods of use
Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are...
|
|
|
6201108 |
TGF-β type receptor cDNAs encoded products and uses therefor
DNA encoding TGF-β TYPE III receptor of mammalian origin, DNA encoding TGF-β type II receptor of mammalian origin, TGF-β type III receptor, TGF-β type II receptor and uses therefor.
|
|
|
6200770 |
Protein kinase molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated CSAPK nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules,...
|
|
|
6197937 |
Modified low density lipoprotein receptor
The present invention provides a DNA sequence essentially encoding a mammalian vascular endothelial receptor for modified low-density lipoprotein. The sequence is set forth in the Sequence No. 1, 2...
|
|
|
6191261 |
Growth differentiation factor-9 antibodies and methods
Growth differentiation factor-9 (GDF-9) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-9...
|
|
|
6184359 |
Antibodies to epithelium-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
|
|
|
6184358 |
IP-10/Mig receptor designated CXCR3, antibodies, nucleic acids, and methods of use therefor
The present invention relates to proteins or polypeptides, referred to herein as isolated and/or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3...
|
|
|
6183971 |
Human betacellulin-specific antibodies and uses thereof
Disclosed are an antibody which have a binding activity to human betacellulin protein or a mutein thereof with specificity; especially a monoclonal antibody which does not have cross reactitivity...
|
|
|
6184357 |
Prostate-specific kallikrein
The present invention provides a human prostate-specific kallikrein (HPSK) and polynucleotides which identify and encode HPSK. The invention also provides genetically engineered expression vectors...
|
|
|
6177254 |
Nucleolus autoantigenic marker for systemic lupus erthyematosus
A novel nucleolus protein has been identified and cloned using human autoimmune serum. Its cDNA and amino acid sequences have been determined and are disclosed. This antigenic protein, termed...
|
|
|
6174997 |
Cloning and uses of the genetic locus BCL-6
This invention provides an isolated vertebrate nucleic acid molecule the bcl-6 locus. This invention also provides an isolated human nucleic acid molecule of bcl-6 locus. This invention further...
|
|
|
6172198 |
PAPP-A, its immunodetection and uses
This invention concerns PAPP-A, its immunodetection and the clinical benefits of such immunodetection. Specifically, the invention includes monoclonal antibodies against PAPP-A and the use of these...
|
|
|
6172199 |
Human ubiquitin-conjugating enzyme
The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors...
|
|
|
6171587 |
Antibodies to tissue factor inhibitor
A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined. Antibodies having a...
|
|
|
6169167 |
Antibodies to ligands for HEK4 receptors
Polypeptides which bind to one or more EPH-like receptors, particularly the HEK4 receptor, are described. The polypeptides are designated HEK4 binding proteins. Nucleic acids encoding HEK4 binding...
|
|
|
6168791 |
Antibodies that bind immunomodulators
This invention relates to a polypeptide other than human interleukin (10) which has at least one of the following properties: a) induces inhibition of spontaneous IL-8 production by human...
|
|
|
6166185 |
Antibodies to human TIE-2 ligands
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2...
|
|
|
6165731 |
Assay for the ubiquitination-promoting activity of human proteins
A method is provided for identifying an compound that affects an activity of a polypeptide subunit of a SCF complex. The method includes contacting a sample comprising a chimeric SCF complex...
|
|
|
6162902 |
Human BNP-specific antibodies
The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes...
|
|
|
6156876 |
D-type cyclin and uses related thereto
A novel class of cyclins, referred to as D-type cyclins, of mammalian origin, particularly human origin, DNA and RNA encoding the novel cyclins, and a method of identifying other D-type and non-D...
|
|
|
6156564 |
Cellular apoptosis susceptibility protein (CSP) and antisense CSP
The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of CAS gene in normal and cancer cells. An antisense CAS gene...
|
|
|
6153732 |
Kit for detecting analyte indicative of type II collagen resorption in vivo
Immunoassay test kit for detecting analyte indicative of type II collagen resorption in vivo. including an immunological binding partner which binds to an amino-terminal or carboxy-terminal...
|
|
|
6150120 |
Methods to assay a thrombopoietin signaling defect in polycythemia vera platelets
Impaired TPO-mediated platelet protein tyrosine phosphorylation was consistently observed in patients with polycythemia vera (PV) as well as those with idiopathic myelofibrosis (IMF), in contrast...
|
|
|
6150116 |
Transcription factor DP-1 antibody
The invention provides a polynucleotide in substantially isolated form which includes a contiguous sequence of nucleotides which is capable of selectively hybridizing to SEQ ID NO: 1 or the...
|
|
|
6146633 |
Method for treatment of antigenically modified polypeptides
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the...
|
|
|
6147194 |
Eukaryotic IMPDH polynucleotide and antibody compositions
Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g.,...
|
|
|
6143874 |
Antibodies to the neurotrophic factor NNT-1
Disclosed are nucleic acids encoding novel neurotrophic factors, designated NNT-1. Also disclosed are amino acid sequences for NNT-1 polypeptides, methods for preparing NNT-1 polypeptides, and...
|
|
|
6143509 |
Prostate specific antigen peptides and uses thereof
The present invention relates to peptides which may be used, for example, in the detection of free and complexed Prostate Specific Antigen and thus in the diagnosis of prostate cancer.
|
|
|
6143273 |
Therapeutic composition containing antibodies to soluble polypeptide fractions of LAG-3 protein
Soluble polypeptide fraction consisting of all or part of one at least one of the four immunoglobulin-type extracellular LAG-3 protein domains (amino acids 1-159, 160-230, 240-330 and 331-412 of...
|
|
|
6143875 |
Antibody to DNase involved in apoptosis
The present invention relates to novel DNases α, β and γ capable of selectively cleaving the linker sites of chromatin DNA. The present invention also relates to novel DNase γ involved in...
|
|
|
6140473 |
Antibodies specific for MTS2 Polypeptide
The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further...
|
|
|
6140064 |
Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3
The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells...
|
|
|
6136957 |
Antibodies which bind granulocyte-macrophane colony-stimulating factor receptor
The invention provides a recombinant or synthetic receptor or a derivative thereof, for granulocyte-macrophage colony-stimulating factor (GM-CSF). The GM-CSF receptor is useful, inter alia, in the...
|
|
|
6136958 |
Antibodies to vertebrate smoothened proteins
Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and...
|
|
|
6133426 |
Humanized anti-IL-8 monoclonal antibodies
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed...
|
|
|
6132980 |
Antibodies specific for TRP-2 a human tumor antigen recognized by cytotoxic T lymphocytes
The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized...
|
|
|
6124436 |
Purified mammalian monocyte antigens and related reagents
Cell surface antigens from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
|
|
|
6124439 |
OB polypeptide antibodies and method of making
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and...
|
|
|
6124438 |
Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
Antibodies or epitope-binding portions thereof raised to a synthetic polypeptide having an amino acid sequence that corresponds substantially to an amino acid residue sequence of at least a portion...
|
|
|
6121003 |
Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use
|
|
|
6121002 |
Method to detect bone and other connective tissue disorders in humans and animals
The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free...
|
|
|
6117981 |
Hybridomas for lung cancer marker and monoclonal antibodies thereof
Hybridomas secreting monoclonal antibodies specific for an epitope found in the amino acids of LCGA associated with non-small cell lung carcinoma protein have been found. The monoclonal antibodies...
|
|
|
6110690 |
SODD-specific antibodies and methods
The invention provides methods and compositions relating to Suppressor of Death Domain (SODD) proteins which regulate cellular signal transduction and transcriptional activation, and related...
|
|
|
6110722 |
F.sub.0 ATP synthase subunit
The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules,...
|
|
|
6110507 |
Human 3-hydroxyisobutryl-coenzyme a hydrolase
The present invention provides a human 3-hydroxyisobutyryl-coenzyme A hydrolase (HIBCOH) and polynucleotides which identify and encode HIBCOH. The invention also provides expression vectors, host...
|
|
|
6111080 |
Monoclonal antibodies
A monoclonal antibody which specifically reconizes a receptor that binds to proteins that contain the amino acid sequence Arg-Gly-Asp which on binding said proteins causes the cells to become...
|
|
|
6107047 |
Assaying protein fragments in body fluids
Degradation of body proteins such as bone collagen is studied by detecting in body fluids isomerized peptide fragments of said proteins in which peptide bonding to the α-carboxylic acid group of...
|