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6344543 |
Human transcription factor IIA
The small (γ) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods...
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6344544 |
Semaphorin-specific antibodies
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin...
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6344339 |
Monoclonal antibodies against the extracellular domain of human VEGF-receptor protein (KDR)
Monoclonal antibodies, secreted by hybridoma cell lines, that are directed against an epitope of the extracellular domain of human VEGF-receptor KDR, methods of determining human VEGF-receptor KDR...
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6340743 |
Antibodies to PIGR stalk
Antibody ligands are provided for specific binding to the stalk of a polymeric immunoglobulin receptor (plgr) of a cell with the proviso that the ligand does not substantially bind to secretory...
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6331301 |
Antibodies specific for vascular endothelial growth factor-B
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides,...
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6329159 |
Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The...
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6326471 |
Immunogenic peptides of prostate specific antigen
Peptides derived from prostate specific antigen (PSA) that correspond to the immunodominant epitopes found in the native antigen are disclosed. These peptides were identified using a method that...
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6323324 |
Test kits for detecting the presence of C-terminal hGPIIb fragments
Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
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6319499 |
Methods for activating an erythropoietin receptor using antibodies
Antibodies and fragments thereof which activate an erythropoietin receptor and stimulate erythropoiesis are described. Also described are hybridoma cell lines which produce the antibodies and...
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6316412 |
Polypeptides for promoting cell attachment
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394...
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6313266 |
Human nucleolin-like protein
The invention provides a human nucleolin-like protein (HNLP) and polynucleotides which identify and encode HNLP. The invention also provides expression vectors, host cells, antibodies, agonists,...
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6309637 |
Human microfibril-associated glycoprotein 4 splice variant
The invention provides a human microfibril-associated glycoprotein 4 splice variant (MAG4V) and polynucleotides which identify and encode MAG4V. The invention also provides expression vectors, host...
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6309863 |
Methods for generating phosphorylation site-specific immunological reagents
The present invention provides methods for generating phosphorylation site-specific immunological reagents. More specifically, a phosphopeptide mimetic is incorporated into a polypeptide in place...
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6306608 |
Anti-human LECT2 antibody, cells producing the same, and method and kit for assaying the same
An antibody reacting specifically with human LECT2. This antibody is produced by hybridoma clones G2A5D7 (Accession No. FERM P-15638), A1G1C6 (Accession No. FERM P-15639), 5C5 (Accession No. FERM...
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6306615 |
Detection method for monitoring β tubulin isotype specific modification
This invention relates to monoclonal antibodies that recognize modified β-tubulin isotypes, methods of using such antibodies to detect modified β-tubulin isotypes, methods of using such...
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6307021 |
Human apoptosis regulator
The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors...
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6307027 |
Bradykinin B1 receptor antibodies
DNAs encoding bradykinin B 1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind desArg 10 kallidin and other B...
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6303323 |
Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the...
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6303755 |
Therapeutic multispecific compounds comprised of anti-FCA receptor antibodies
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies and methods of use are provided.
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6300477 |
Antibodies to human cystatin E
Disclosed are antibodies and antibody fragments that bind to novel human CysE polypeptides. Also provided are methods for producing the antibodies. Also disclosed are methods for utilizing such...
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6300472 |
Rab proteins
The invention provides three human Rab proteins (RABP) and polynucleotides which identify and encode RABP. The invention also provides expression vectors, host cells, agonists, antibodies and...
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6300476 |
Anti-peptide antibody against human cytochrome P450 3A4
Anti-peptide antibody raised against a portion of human cytochrome P450 3A4 is disclosed. A particular anti-peptide antibody was raised against a 21-amino acid peptide corresponding to residues...
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6300479 |
Antibodies specific for human thymosin β15 protein and uses thereof
The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin β family. This novel protein, herein referred to as thymosin β15, has the ability to...
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6299877 |
Type I interferons
The invention concerns a novel human interferon-ε, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-α family...
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6297361 |
Use of histidine decarboxylase immunoreactivity to detect human cancer
The present invention provides a purified antibody which specifically reacts with human histidine decarboxylase (HDC), as well as immunogenic compositions comprising HDC peptides.
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6294655 |
Anti-interleukin-1 receptor antagonist antibodies and uses thereof
The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were...
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6290958 |
Anti-flea epoxide hydrolase antibodies and uses thereof
The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to...
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6291653 |
Antibodies to motilin homologs
The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of...
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6291651 |
Antibodies to a novel src-family kinase
The present invention provides a unique src-family kinase (SFK) that plays a key role in the transformation of early-stage embryonic cells to mesodermal cells. Furthermore, this src-family kinase...
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6277963 |
Antibodies directed toward extracellular signal-related kinases
The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and...
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6274710 |
Antibodies which specifically bind T Cell inducible factors (TIFs)
The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid...
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6262239 |
TNF receptor-specific antibodies
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF...
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6261560 |
Method for inhibiting muscle protein proteolysis with antibodies to interleukin-6 receptor
The present invention provides a muscle protein proteolysis inhibiting agent comprising antibody to Interleukin-6 receptor (IL-6R antibody). Antibodies of animals other than humans such as mice and...
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H001973 |
Human neutrophil collagenase splice variant
The subject invention is related to human MMP-8alt genes and gene products and their differential expression when comparing a patient with a disease state to a control. A further aspect of the...
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6248326 |
Regulation of osteoclast formation by inhibition of osteoblastic stem cell factor
The present invention provides an inhibitor of osteoblastic stem cell factor binding and/or activity, for example, an antibody or an antisense oligonucleotide. Also provided are pharmaceutical...
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6248546 |
Assay of IGFBP complex
A method of assaying the growth hormone status of an individual by immuno-assay for the 150 KDa Insulin-like Growth Factor ternary complex (IGF/IGFBP-3/ALS). Alternatively, a binary complex may be...
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6245896 |
Antibodies that binds growth differentiation factor 5
Growth differentiation factor-5 (GDF-5) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-5...
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6242575 |
Antibodies for detecting p27 protein
The subject invention provides an isolated protein having an apparent molecular weight of about 27 kD and capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. The subject...
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6242576 |
Monoclonal and polyclonal antibodies relating to fragile X syndrome
The DNA sequence spanning the fragile X site on the X human chromosome has been obtained in purified and isolated form. As fragile X is associated with mental retardation, the availability of a DNA...
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6238666 |
RANTES homolog antibody
The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a human rantes homolog (PTEC). The invention provides for genetically...
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6239260 |
Binding compositions specific for interleukin-10
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) or interleukin 10 (IL-10), as well as antibodies which specifically bind IL-10, are provided. These proteins,...
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6235879 |
Apoptosis modulators that interact with the Huntington's disease gene
A family of proteins, including a specific human protein designated as HIP1, has been identified that interact differently with the gene product of a normal (16 CAG repeat) and an expanded (>44...
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6232446 |
TNF ligands
Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed together with methods of producing them. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not...
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6232064 |
Methods of diagnosing a pathology characterized by a cell proliferative disorder associated with connective tissue growth factor
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with...
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6228597 |
Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
The invention concerns a polypeptide possessing thyrotropin receptor activity characterized in that it comprises the amino acid sequence shown in FIG. 11 (i.e., SEQ ID NO: 59) and cDNA molecules...
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6228600 |
Immunoassays for the alpha platelet-derived growth factor receptor
Recombinant DNA technology was used to clone encoding nucleic acids for the human alpha platelet-derived growth factor receptor (PDGF-R type alpha). Peptides corresponding to the predicted sequence...
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6224867 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Tumor necrosis factor-α and -β receptors
Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
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6218131 |
Materials and methods for detection of breast cancer
Disclosed are proteins indicative of breast cancer and of other cancers, and methods for their detection. Methods of the invention provide an improvement in cancer detection assays, especially in...
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6218514 |
Antibodies specific for soluble truncated integrins
tr-αIIb, a soluble, truncated integrin found to be exclusively expressed in tumor cells is provided. An additional truncated integrin, tr-β3, has also been found to be exclusively expressed in...
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6211340 |
δ-sarcoglycan antibodies
Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (δ-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the...
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