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6479640 |
Antibody specific for a protein tyrosine phosphatase that localizes to focal adhesions
An antibody is provided that is specific for a PTPH1 protein, a phosphatase that dephosphorylates phosphotyrosine residues in phosphoproteins having tyrosyl residues that are phosphorylated by...
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6472195 |
Human kallikrein
The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKALL. The invention also provides expression vectors and host cells, agonists,...
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6469144 |
Apo-2LI and Apo-3 polypeptides
Novel polypeptides, designated Apo-3 and Apo-2LI, involved in apoptosis are provided. Compositions including chimeric molecules, nucleic acids, and antibodies are also provided.
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6464978 |
Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations
The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The...
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6458932 |
Interferon-α/β binding protein, its preparation and use
Interferon α/β binding proteins are provided, which are capable of modulating the activity of interferon-α subtypes as well as interferon-β. Cloning of DNA molecules encoding these proteins,...
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6455039 |
Anti-parasitic helminth macrophage migration inhibitory factor antibodies and uses thereof
The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF...
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6455498 |
Structural alterations of the EGF receptor genes in human tumors
Deletions in the EGF-R gene are found in many gliomas, breast tumors, and lung tumors. A particular truncated EGFR protein has been found in many tumors and provides diagnostic and therapeutic...
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6455040 |
Tumor necrosis factor receptor 5
The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic...
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6451760 |
Treatment of inflammation using a 2F1 polypeptide or an antibody thereto
2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting...
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6451981 |
Antibodies against lymphocyte-associated cell surface protein LAM-1
Human lymphocyte-associated cell surface protein LAM-1, which includes domains homologous with binding domains of animal lectins, growth factors, and C3/C4 binding proteins, and the cDNA encoding...
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6447776 |
Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors
The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the...
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6448020 |
Molecules associated with the human suppressor of fused gene
The present invention relates to proteins, polypeptides and nucleotides related to the human homologue of the Drosophila suppressor of fused gene, which is involved in the transduction of signals...
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6441142 |
Immunoassay for peanut allergen
Peanuts are a common cause of food hypersensitivity reactions. The sera of 10 patients who had atopic dermatitis and a positive double-blind placebo-controlled food challenge to peanut were used to...
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6440935 |
Inhibition of eucaryotic pathogens and neoplasms and stimulation of fibroblasts and lymphocytes with lytic peptides
Inhibition of eucaryotic pathogens and neoplasms and stimulation of lymphocytes and fibroblasts with lytic peptides such as cecropins and sarcotoxins. Eucaryotic cells are contacted with cecropin...
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6432708 |
Human choline acetyltransferase
Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods...
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6428966 |
Growth differentiation factor, lefty-1
Growth differentiation factor Lefty-1 polypeptide and polynucleotides are provided herein. Also disclosed are diagnostic and therapeutic methods of using the Lefty-1 polypeptide and polynucleotide...
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6420543 |
Growth differentiation factor-15
Growth differentiation factor-15 (GDF-15) polynucleotide sequence and amino acid sequence are provided herein. Also described are diagnostic and therapeutic methods of using GDF-15 polypeptide and...
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6419924 |
Antibodies of isolated domains of type IV collagen modify cell interactions
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and...
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6416991 |
Human cyclic nucleotide PDES
The invention provides human cyclic nucleotide phosphodiesterases (HSPDE10A) and polynucleotides which identify and encode HSPDE10A. The invention also provides expression vectors, host cells,...
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6413726 |
Antibodies that specifically bind Cytostatin III
The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and...
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6406867 |
Antibody to human endokine alpha and methods of use
The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha...
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6407215 |
Antibodies to Mch2, an apoptotic cysteine protease
A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2α, and an inactive isoform of it, Mch2β, are disclosed. Isolated nucleic acid molecules...
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6407216 |
Vertebrate smoothened antibodies
Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and...
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6403088 |
Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3)
The invention provides antibodies that are reactive with VEGF-C, a polypeptide ligand for Flt4 receptor tyrosine kinase (VEGFR-3).
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6399350 |
KUZ, a novel family of metalloproteases
Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invention provides KUZ poylpeptides, antibodies that...
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6399065 |
Methods for modulating SLAM-expressing T cells
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen. Methods of using...
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6399054 |
Method for the production of activated marked tumor-specific T cells and use thereof in treatment of tumors
A method for the production of activated tumor-specific T cells by co-cultivating, ex vivo, tumor cells from a patient with T cells from that patient, comprising the steps of: i) incubating the...
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6395273 |
Prevention and treatment of inflammatory bowel disease
Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to TNF are shown to have a beneficial effect in animal...
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6392019 |
Antibodies specific for EGF motif proteins
The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins....
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6392014 |
Cloning of gene encoding the GP28.5 protein of Toxoplasma gondii; peptide fragments of said protein and their applications
The invention relates to cloning of the gene for the toxoplasma GP28.5 antigen. It also encompasses purified GP28.5 antigen preparations and antigenic polypeptides derived from said antigen, and...
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6387673 |
Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
In accordance with the present invention, it has been discovered that histone deacetylase associates with hormone receptor complexes and contributes to the repression thereof. It has further been...
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6387698 |
MAGE-10 encoding CDNA, the tumor rejection antigen precursor MAGE-10, antibodies specific to the molecule, and uses thereof
Isolated cDNA molecules which encode the tumor rejection antigen precursor MAGE-10, the protein itself, antibodies to it, and uses of these are part of the invention.
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6383737 |
Human oxalyl-CoA Decarboxylase
A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against...
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6372891 |
Human G-protein receptor HPRAJ70
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were...
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6365716 |
Antibodies to lipocalin homologs
The present invention is directed to antibodies to polypeptides for a member of the lipocalin family. The expression of the polypeptide is restricted to testis and mammary gland, particularly...
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6361954 |
Methods of immunoassay for human CDC6
The invention pertains to novel genes which function in the regulation of DNA replication and/or entry of a cell into mitosis. Tile invention also pertains to novel proteins encoded by the genes...
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6361773 |
Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins
This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive...
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6358711 |
Antibody to human testin and methods of making and using
The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists....
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6355245 |
C5-specific antibodies for the treatment of inflammatory diseases
The use of anti-C5 antibodies, e.g., monoclonal antibodies, to treat glomerulonephritis (GN) is disclosed. The administration of such antibodies at low dosage levels has been found to significantly...
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6355442 |
METHOD OF ASSAYING COLLAGEN FRAGMENTS IN BODY FLUIDS, A TEST KIT AND MEANS FOR CARRYING OUT THE METHOD AND USE OF THE METHOD TO DIAGNOSE THE PRESENCE OF DISORDERS ASSOCIATED WITH THE METABOLISM OF COLLAGEN
A method of assaying collagen fragments in body fluids, including bringing a sample of body fluid in contact with at least one immunological binding partner for the collagen fragments, said binding...
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6350450 |
TIE ligand homologue antibody
The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5 and NL8, the proteins encoded by such nucleic acid molecules, as well as methods and means for...
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6350583 |
Reagents and methods useful for detecting diseases of the prostate
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for...
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6348320 |
Cartilage resorption assays measuring type II collagen fragments
Immunoassays for measuring type II collagen (cartilage) resorption in vivo employ either one or two antibodies. A first antibody binds to DEKAGGA (SEQ ID NO:21) but not to GGFDEKAGGAQLG (SEQ ID...
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6346246 |
Antibodies that bind human haemopoietic maturation factor
Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides...
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6346377 |
Screening for papilloma viruses
The invention relates to a method of screening for precursor lesions which can lead to cervical malignancy, methods of detecting and typing human papilloma virus infections, and reagents of use in...
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6344543 |
Human transcription factor IIA
The small (γ) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods...
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6344544 |
Semaphorin-specific antibodies
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin...
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6344339 |
Monoclonal antibodies against the extracellular domain of human VEGF-receptor protein (KDR)
Monoclonal antibodies, secreted by hybridoma cell lines, that are directed against an epitope of the extracellular domain of human VEGF-receptor KDR, methods of determining human VEGF-receptor KDR...
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6340743 |
Antibodies to PIGR stalk
Antibody ligands are provided for specific binding to the stalk of a polymeric immunoglobulin receptor (plgr) of a cell with the proviso that the ligand does not substantially bind to secretory...
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6331301 |
Antibodies specific for vascular endothelial growth factor-B
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides,...
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