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6608179 |
Antibodies, that bind to HIV-2 transmembrane glycoprotein homodimer (gp 80)
Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for...
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6605278 |
Uses of trank, a novel secretory cytokine
The present invention provides methods for the therapeutic application of TRANK, a novel cytokine. TRANK is secreted by cells and activates NF-κB, c-Jun N-terminal kinase (JNK) and downstream gene...
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6602993 |
DNA molecule encoding TNF binding ligands and vectors and host cells containing the DNA molecule
DNA encoding Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not its binding to the TNF-Rs....
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6600022 |
Monoclonal antibody for human IL-18 receptor
Disclosed are a receptor protein which recognize a novel cytokine, i.e., interleukin-18, a monoclonal antibody specific to the protein, and uses thereof. The receptor protein is useful as...
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6596851 |
Inducible phosphofructokinase and the Warburg effect
There is disclosed a cancer malignancy diagnostic assay comprising obtaining a sample of a body fluid or tissue, performing a sequence identity assay to look for the presence of iPFK-2 specific...
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6596852 |
Antibodies that bind the cytokine designated LERK-5
LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the...
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6596277 |
Methods of decreasing cell adhesion
The present invention provides substantially pure integrins containing a novel β subunit designated as β 6 . The novel β 6 subunit forms heterodimers with α V and α F . Methods of...
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6593458 |
Tumor necrosis factor peptide binding antibodies
Provided are isolated antibodies or fragments thereof which bind a peptide consisting of residues Leu 63 -Phe 64 -Lys 65 -Gly 66 -Gln 67 -Gly 68 -Cys 69 -Pro 70 -Ser 71 -Thr 72 -His 73 -Val 74 -Leu...
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6589756 |
Immunoassays using anti-allotypic monoclonal antibodies
The invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as...
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6579684 |
Assay of YKL-40 as a marker for cancer
This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects...
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6576445 |
Chemokine α-4
The present invention relates to a novel CKα-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-4 protein....
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6573365 |
Antibodies for NF-AT interacting protein, NIP45
Isolated nucleic acid molecules encoding a novel protein, NIP45, that interacts with members of the Nuclear Factor of Activated T cell (NF-AT) family of proteins, are disclosed. The invention...
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6569996 |
Antibody that specifically binds to the cadherin-5 cell adhesion recognition sequence
Modulating agents for inhibiting or enhancing nonclassical cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50%...
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6569995 |
Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells
A G protein-coupled receptor (GPCR) which is activated by oncogenes. The receptor is found predominantly in hematopoietic cells and tissues and functions as a tumor suppressor gene and induces cell...
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6566505 |
Antibodies to Mch6 polypeptides
The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The...
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6566082 |
T-cell antigens, and their use in diagnosis and treatment of T-cell mediated conditions
The OX-40 antigen is characterized and claimed together with variants and derivatives thereof. Also described are binding agents for the antigen and the use of these in diagnosis and therapy....
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6562948 |
Receptor activator of NF-&kgr B
Provided herein are isolated antibodies that specifically bind a RANK polypeptide.
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6562579 |
Diagnostic methods using antibodies to Neutrokine-alpha
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In...
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6562949 |
Antibodies to viral encoded semaphorin protein receptor polypeptides
The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for...
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6562578 |
IL-17-like cytokine binding compounds and antibodies
IL-17-like cytokines from mammals, reagents and diagnostic kits related thereto including purified proteins, specific antibodies, and nucleic acids are provided. Methods of using the reagents and...
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6559286 |
Antibodies to occludin proteins
The present invention discloses antibodies that bind to mammalian occludin proteins which are transmembrane adhesion molecules of the tight junction. Nucleic acid and amino acid sequences encoding...
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6559285 |
Nucleotide and protein sequences of lats genes and methods based thereon
The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats...
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6555111 |
Method of inhibiting the cytocidal effect of TNF with TNF receptor-specific antibodies
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF...
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6552164 |
Reagents and methods useful for detecting diseases of the breast
This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the breast such as breast cancer. Furthermore, the...
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6548066 |
Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
The invention concerns immunogens, immunogenic compositions and method for the treatment of gastrin-dependent tumors. The immunogens comprise a peptide from the CCK-B/gastrin-receptor conjugated to...
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6545129 |
Human selenoprotein
The present invention provides a human selenoprotein (HSEL) and polynucleotides which identify and encode HSEL. The invention also provides genetically engineered expression vectors and host cells...
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6541275 |
Immunoassay for F1.2 prothrombin fragment
According to the present invention highly specific-low affinity antibodies are generated which allow for the assay of F1.2 in bodily fluids that also contain prothrombin or other plasma proteins....
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6541217 |
Hematopoietic stem cell growth factor (SCGF)
The present invention provides a novel polypeptide possessing growth activities on hematopoietic stem cells, a gene encoding the polypeptide and an antibody reacting specifically with the...
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6538111 |
Antibody against human interleukin-5 receptor alpha chain
The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor α chain. The invention also provides hybridomas and...
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6534634 |
Diagnostic agent and method to determine pregnancy in ruminants
The present invention relates to diagnosis aids and processes for detecting pregnancy in ruminants based on the relaxin-like factor detectable in ruminants. Antibodies against the relaxin-like...
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6528493 |
Screening methods for identifying modulators of proliferation and differentiation of bone cells
The present application relates to a compositions comprising a compound which modulates the activity of T1-M protein, the use of compounds which modulate the activity of T1-M protein, and an in...
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6525180 |
Antibodies to mammalian T cell surface antigen
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided....
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6518403 |
Antibodies that bind an adipocyte-specific protein homolog
The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The...
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6518404 |
Human endothelin-bombesin receptor antibodies
A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying...
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6518405 |
Mammalian proteinases; oxidoreductases; related reagents
Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related...
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6511665 |
Antibodies to interleukin-1 receptors
The present invention provides monoclonal antibodies and binding proteins which specifically bind to the IL-1 receptor. Also provided are methods for detecting IL-1 receptors on cells, and for...
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6506882 |
Antibodies that bind tumor necrosis factor delta
The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the...
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6506571 |
Human glutathione-S-transferase
The invention provides a human glutathione-S-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides expression vectors, host cells, agonists, antibodies...
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6500428 |
Antibodies to a lymphocyte surface receptor that binds CAML and methods of use thereof
A novel lymphocyte receptor protein, its DNA sequence, and its role in the calcium activation pathway is described. The protein, or genetically engineered constructs encoding it, are shown to...
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6495667 |
Il-b30 antibodies
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
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6492496 |
Antibodies to the receptor protein designated 2F1
2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting...
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6492495 |
PTP-S31: a novel protein tyrosine phosphatase
A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this;family are PTP-S31 proteins or glycoproteins...
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6489448 |
Antiparasitic helminth larval thiol specific antioxidant-antibodies, and uses thereof
The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA...
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6489126 |
Method of identifying cells expressing a protein having pre-B cell growth-supporting ability
A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability, and a novel membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell...
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6482929 |
Antibodies to ARF-p19
The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor (InK4a-p16) of the cyclin D-dependent kinases CDK4 and CDK6. InK4a-p16 can block these kinase from phosphorylating the retinoblastoma...
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6482408 |
Fibroblast growth factor 15 antibodies
The present invention relates to antibodies directed to the human protein called Fibroblast Growth Factor 15.
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6482599 |
Forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such
A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid...
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6479639 |
Monoclonal antibody to a human MDR1 multidrug resistance gene product and uses
A hybridoma (termed “UIC2 hybridoma”, ATCC Accession No. HB11027) producing monoclonal antibodies (termed “UIC2 mAb”) directed against an extracellular domain of a cell surface...
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6479638 |
Antibodies that specifically bind DNAX leukocyte associated immunoglobulin-like receptor
Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using reagents...
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6479459 |
Cytokine designated lerk-5
LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the...
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