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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7598051 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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7569390 |
Selection of intracellular immunoglobulins
A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This...
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7560242 |
Metadherin polypeptides, encoding nucleic acids and methods of use
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the...
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7452676 |
Monoclonal antibodies to RNA binding protein GW182
The present invention includes antibodies to human GW182 protein and the use of those antibodies in clinical and diagnostic assays.
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7449176 |
Treatment of inflammatory bowel disease with IFN-γ inhibitors
The invention concerns a method for the prevention or treatment of inflammatory bowel disease by administering an interferon-γ inhibitor. The invention further concerns pharmaceutical compositions...
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7335467 |
Breast cancer antigens
The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses...
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7273924 |
Antibodies to the ED-B domain of fibronectin, their construction and uses
A specific binding member is specific for and binds directly to the ED—B oncofoetal domain of fibronectin (FN).
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7270961 |
In vitro assay for quantitating secreted antibodies in lymphocyte supernatant for evaluation of vaccine or antigen induced specific antibody secretion from ex vivo circulating antibody-secreting lymphocytes
The present invention provides methods of quantitating recent secreted antigen specific antibodies from supernatant of antibody secreting cells (ASC) in vitro culture for evaluation of vaccine or...
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RE39789 |
Tumor therapy
Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and...
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7253142 |
Protein solution preparation and method of stabilizing the same
The present invention provides stable protein solution formulations filled in a container made from a hydrophobic resin at least for the part in direct contact with said formulation.
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7244826 |
Internalizing ERB2 antibodies
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the...
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7223844 |
Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes
The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4,...
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7183384 |
Monoclonal antibody 7H11 reactive with human cancer
Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of...
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7122635 |
Method and composition for angiogenesis inhibition
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple...
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7118924 |
Method for producing human antibodies in SCID mice which uses dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes as immunizing agents
An improved method for producing human antibodies in SCID mice is provided. The improvement includes the use of dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes...
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7108986 |
Glypican-1 in human breast cancer
Glycosylphosphatidylinositol-(GPI-) anchored HSPG glypican-1 is strongly expressed in human breast and pancreatic cancer—both by the cancer cells and in the case of pancreatic cancer the adjacent...
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7097966 |
Detection of survivin in the biological fluids of cancer patients
The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising...
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7090983 |
Methods for detecting early cancer
MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of...
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7081517 |
Genes differentially expressed in breast cancer
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of...
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7053041 |
Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin α v β 5 antagonists. The α v β 5 -mediated angiogenesis is correlated with exposure to...
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7030227 |
Cell regulatory genes, encoded products, and uses related thereto
This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected...
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7022821 |
Antibody kit for the detection of TADG-15 protein
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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6953847 |
Fas antigen derivative
This invention provides a novel Fas antigen derivative which comprises at least a part or entire portion of Fas antigen extracellular region polypeptide in which at least one amino acid residue is...
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6936424 |
Materials and methods for detection and treatment of breast cancer
The invention provides a wide range of methods and compositions for detecting and treating breast cancer in an individual. Specifically, the invention provides target breast cancer-associated...
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6911316 |
Medical uses of scuPA/suPAR complex
Methods of using a complex (scuPA/suPAR) which has thrombolytic activity under physiological conditions and in the presence of IgG, or of at least one IgG-derived peptide, which complex comprises a...
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6905684 |
Preventives and remedies for diffuse lung diseases
Preventives and remedies for diffuse lung diseases whereby apoptosis can be inhibited and thus favorable preventive/therapeutic effects can be established. These drugs contain apoptosis-inhibiting...
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6891022 |
NSP molecules
The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing,...
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6872537 |
Assays for the detection of microtubule depolymerization inhibitors
This invention provides methods for the screening and identification of agents having potent effects on the progression of the cell cycle. In one embodiment, the methods involve contacting a...
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6861510 |
Immunogenic compositions against gastrin peptides
Immmunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies...
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6861509 |
Antibodies to Ret and RetL3
Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients.
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6858710 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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6846911 |
Methods and compositions for inhibiting inflammation and angiogenesis comprising a mammalian CD97 α subunit
Isolated proteins comprising the T-cell surface antigen CD97 α are provided. Compositions and methods for making and detecting CD97 α are also provided. Further, the invention provides diagnostic...
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6828422 |
Protein/(poly)peptide libraries
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA...
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6764827 |
Anti-human medullasin monoclonal antibody process for producing the same and immunoassay using the same
A monoclonal antibody by which medullasin that is a kind of serine proteases existing in granulocytes, production process thereof and an immunoassay of human medullasin using the antibody are...
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6759042 |
Use of cross-linked, covalently bound urokinase plasminogen activator (scuPA)-urokinase plasminogen activator receptor (suPAR) complex as a fibrinolytic agent
The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic...
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6753154 |
Human AZU-1 gene, variants thereof and expressed gene products
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of...
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6730301 |
MCP-1 receptor antibodies
Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in...
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6709832 |
Method of early diagnosis of carcinomas
The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a...
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6692927 |
Bax degradation involvement in tumor survival and progression
According to the present invention, there is provided an assay for determining Bax degradation activity in a patient sample. The assay includes a labeled Bax protein which is incubated with a...
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6613377 |
Whey treatment process for achieving high concentration of α-lactalbumin
A method of making an α-lactalbumin enriched whey protein product is described. The method involves the treatment of a whey protein product with an acid to lower the pH of the whey protein product...
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6589756 |
Immunoassays using anti-allotypic monoclonal antibodies
The invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as...
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6576445 |
Chemokine α-4
The present invention relates to a novel CKα-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-4 protein....
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6552164 |
Reagents and methods useful for detecting diseases of the breast
This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the breast such as breast cancer. Furthermore, the...
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6545128 |
Anti-bax inhibitor protein antibodies
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
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6541214 |
N-terminally truncated HER-2/neu protein as a cancer prognostic indicator
There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western...
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6509316 |
Pharmaceutical compositions, methods, and kits for treatment and diagnosis of lung cancer
The present invention relates to pharmaceutical compositions, methods and kits that provide for the early diagnosis and treatment of lung cancer. More particularly, the present invention relates to...
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6504012 |
Method for preparing dual virally inactivated immune globulin for intravenous administration
A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the...
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6482599 |
Forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such
A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid...
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6441145 |
Transgenically produced Antithrombin III
This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition...
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