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9034822 Methods of using antibodies during anticoagulant therapy of dabigatran and/or related compounds  
The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
9018166 Conjugated FVIII variants  
The present invention relates to conjugated Factor VIII variants. The present invention in particular relates to conjugated FVIII variants comprising different polymeric groups as well as use thereof.
8969524 FVIII peptides for immune tolerance induction and immunodiagnostics  
The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore,...
8945897 Materials and methods for conjugating a water soluble fatty acid derivative to a protein  
The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water...
8940876 Method for preparing recombinant glycoproteins with high sialic acid content  
The present disclosure relates to a method for preparing recombinant glycoproteins with high sialic acid content. More specifically, for UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK) enzyme where...
8889831 Unit dosage forms of pharmaceutical compositions comprising a polymer-factor VIII polypeptide conjugate  
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are...
8865868 Conjugated proteins with prolonged in vivo efficacy  
The invention relates to conjugated proteins, in particular but not exclusively, blood coagulation factors, to processes for preparing the conjugated proteins which contain the steps of reacting a...
8859731 Selective modification of proteins  
A method of selectively introducing a substituent into a protein proximal to a binding site on the protein for a homing peptide, comprising: (a) contacting the protein with a compound comprising a...
8835388 Polymer von Willebrand factor-conjugates  
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to...
8828676 Methods for differentiating plasma-derived protein from recombinant protein in a sample  
The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation,...
8816054 Compositions and methods for enhancing coagulation Factor VIII function  
Factor VIII variants and methods of use thereof are disclosed.
8809501 Nucleophilic catalysts for oxime linkage  
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate...
8765665 Albumin-free factor VIII formulations  
A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of...
8759293 von Willebrand factor (vWF)-containing preparations, and methods, kits, and uses related thereto  
The present invention relates to methods, compositions and kits for preparing FVIII and employing same. Also provided are vWF polypeptides and nucleic acid molecules encoding same.
8686225 Monocot seed product comprising a human blood protein  
The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, as well as to methods of making these isolated blood proteins and...
8642737 Nucleophilic catalysts for oxime linkage  
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate...
8637640 Blood coagulation protein conjugates  
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized...
8618259 Polymer-factor VIII conjugate compositions  
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are...
8598319 Process for separating proteins fibrinogen, factor XIII and biological glue from a solubilized plasma fraction and for preparing lyophilised concentrates of said proteins  
The invention is related to a process for separating proteins fibrinogen, Factor XIII and biological glue from a solubilized plasma fraction and for preparing freeze-dried concentrates of said...
8575102 Conjugates having a releasable linkage  
The present invention provides conjugates encompassed by the following structure, wherein: D is a residue of an active agent bearing at least one amino group; andPEG-m is a methoxy end-capped...
8519102 Polymer Factor VIII moiety conjugates  
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are...
8501694 Method of administering porcine B-domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
8454833 Counter-pressure filtration of proteins  
A method is disclosed for filtering a protein in a liquid mixture in a manner that does not substantially damage or otherwise limit the recovery of the protein in the filtration filtrate. The...
8445448 FVIII peptides and their use in tolerising haemophiliacs  
The present invention provides a peptide comprising a core residue sequence derivable from human FVIII which peptide is capable of binding to an MHC class II molecule without further antigen...
8399620 Purification of factor VIII using a mixed-mode or multimodal resin  
A method for purifying a recombinant protein using a multimodal or mixed mode resin containing ligands which comprise a hydrophobic part and a negatively charged part is described. The invention...
8389687 Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors  
Blood collection, processing and transfer leads to the separation of discrete fractions by adding additional citrate (trisodium citrate) to bring the citrate concentration to 10%-15% w/v thereby...
8388847 Methods of concentrating shear-sensitive biopolymers  
The invention relates generally to methods of concentrating mixtures including shear sensitive biopolymers, such as von Willebrand Factor. Conventional methods of concentrating biopolymers impart...
8372800 Albumin-free factor VIII formulations  
An albumin-free Factor VIII formulation comprising: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from...
8357779 Polymer-von Willebrand factor-conjugates  
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to...
8354377 Use of factor VIIa or factor VIIa equivalents for preventing or attenuating haemorrhage growth, and/or oedema generation following intracerebral haemorrhage (ICH) in a selected subpopulation of ICH patients  
The invention relates to a method for preventing or attenuating one or more complications of intracerebral haemorrhage (ICH), the method comprising: (i) selecting an ICH patient who exhibits one...
8354505 Process for obtaining a concentrate of Von Willebrand factor or a complex of factor VII/Von Willebrand factor and use of the same  
A concentrate of Von Willebrand Factor (VWF) or a complex of Factor VIII/VWF is prepared by creating a solution of VWF or a complex of Factor VIII/VWF containing VWF at a concentration of up to 12...
8349800 Von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage  
The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for...
8338571 Recombinant factor VIII having increased stability  
The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using...
8329871 Process of purifying coagulation factor VIII  
A process of purifying or enriching coagulation FVIII employing chromatography comprising the steps of providing a fraction containing FVIII in an aqueous solution having a high ionic strength;...
8287850 Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination  
Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of...
8277837 Hemostatic textile  
The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of...
8247536 Factor VIII compositions  
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are...
8183345 Recombinant factor VIII having reduced inactivation by activated protein C  
The present invention relates to a recombinant factor VIII that is characterized by one or more mutations within a region surrounding an activated protein C cleavage site, which one or more...
8183344 Inactivation resistant factor VIII  
The present invention provides novel purified and isolated nucleic acid sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of the present invention encode amino acid...
8173597 Modified recombinant factor VIII and von Willebrand factor and methods of use  
The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of...
8143347 Pegylation of recombinant blood coagulation factors in the presence of bound antibodies  
The present invention relates to a proteinaceous construct comprising a blood coagulation factor, e.g., Factor VIII (FVIII), being bound to at least one water soluble polymer, including a...
8143378 Polymer factor VIII moiety conjugates  
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are...
8133865 von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage  
The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for...
8133977 Polymer-factor VIII moiety conjugates  
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are...
8124737 Stabilized preparations of serine endopeptidases, their preparation and use  
The invention relates to stabilized preparations of serine endopeptidases which are suitable for use as a test reagent in a diagnostic procedure or for a therapeutic use. As a result of the...
8114633 Methods for differentiating plasma-derived protein from recombinant protein in a sample  
The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation,...
8101718 Methods of administering porcine B-domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
8076463 Polymer-von Willebrand factor-conjugates  
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to...
8071728 Factor VIII polymer conjugates  
The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
8071727 Factor VIII polymer conjugates  
The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.

Matches 1 - 50 out of 397 1 2 3 4 5 6 7 8 >