|
Match
|
Document |
Document Title |
|
|
7618943 |
Fusion polypeptides, and use thereof in antivascular tumor therapy
The present invention relates to fusion polypeptides, comprising at least two peptides. The invention further relates to the use of these fusion proteins in antivascular therapy of neoplastic...
|
|
|
7598356 |
Method for purifying a protein of the cystine-knot superfamily
The present invention relates to a two-step method for isolating proteins from the cystine-knot superfamily based on dye ligand affinity chromatography and reversed-phase chromatography....
|
|
|
7598352 |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
A method of identifying a polypeptide monobody having target protein binding activity, said method comprising: providing a host cell comprising (i) a reporter gene under control of a 5′...
|
|
|
7569665 |
Molecular marker
The present invention relates generally to a molecular marker of the integrity of the extracellular matrix in an animal including a human subject. More particularly, the present invention provides...
|
|
|
7521210 |
Method for large-scale production of polypeptide in eukaryote cells and a culture vessel suitable therefor
The invention provides a method for large-scale production of a polypeptide, such as a Factor VII or Factor VIIa polypeptide, in eukaryote cells, such as mammalian cells, contained in a culture...
|
|
|
7494971 |
Pharmaceutical preparations and medicines capable of generating, and/or containing, thrombin
The invention relates to a pharmaceutical active ingredient preparation for producing a medicament that contains thrombin or has a thrombin-generating capacity and compositions comprising thereof....
|
|
|
7459534 |
Inactivation resistant factor VIII
The present invention provides novel purified and isolated nucleic acid sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of the present invention encode amino acid...
|
|
|
7452539 |
Stabilizing polypeptides which have been exposed to urea
Methods for stabilizing polypeptides, such as anti-HER2 antibodies, which have been exposed to urea.
|
|
|
7419949 |
Single-dose administration of factor VIIa
The present invention provides methods for preventing and/or treating bleeding episodes by administering a single dose of Factor VIIa or a Factor VIIa equivalent. Preferably, the single dose...
|
|
|
7419948 |
Treatment of hemophilia with human Factor IX produced in mammary tissue of transgenic mammals
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present...
|
|
|
7390488 |
Compositions and methods for producing vascular occlusion
The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, antibodies carrying...
|
|
|
7375084 |
Highly phosphorylated and sulfated recombinant factor IX
The present invention relates to a purified recombinant blood coagulation factor IX (rFIX) preparation, wherein at least 25% of the rFIX in the preparation is fully phosphorylated and sulfated, a...
|
|
|
7348411 |
Process for manufacturing fibrin membranes and fibrin membranes obtained according to this process
A process for manufacturing a fibrin membrane from blood plasma that was partially depleted and subjected to coagulation by adding a solution of a physiological coagulating agent, leaving the...
|
|
|
7332577 |
Therapeutic human albumin solutions with low prekallikrein activator (PKA) activity and process for obtaining them
The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterised in that it has an antithrombin content...
|
|
|
7300922 |
Modulators of pharmacological agents
The biological activity of nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect. This is accomplished through the administration of a...
|
|
|
7268110 |
Agents for preventing and treating thrombocytopenia
Method of increasing blood platelet formation by administering a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient.
|
|
|
7247451 |
Antithrombin protein and DNA sequences from black fly
The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium . Methods for recombinant production of the protein as well as biomedical uses are provided.
|
|
|
7244825 |
Dried blood factor composition trehalose
A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
|
|
|
7235638 |
Coagulation factor VII derivatives
The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells...
|
|
|
7220836 |
Dried blood factor composition comprising trehalose
A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
|
|
|
7217794 |
Compounds and methods for treatment of thrombosis
The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention...
|
|
|
7211644 |
Diagnostic markers of human female infertility
Methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for...
|
|
|
7176288 |
Human coagulation factor VII variants
The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising...
|
|
|
7169573 |
Method for monitoring coagulability and hypercoagulable states
The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing...
|
|
|
7153830 |
Method for inhibiting the formation of seromas using factor XIII
Use of factor XIII for inhibiting the formation of seromas by administering factor XIII. The factor XIII can be administered locally at the site of a wound or surgery or administered systemically....
|
|
|
7125846 |
Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides
The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and factor V or a factor V-related polypeptide, and the use thereof for treating bleeding...
|
|
|
7115559 |
Method for treating coumarin-induced hemorrhage
Use of factor XIII for treating coumarin-induced hemorrhage or bleeding. The coumarin may be warfarin or dicoumarol. A patient having coumarin-induced bleeding is treated with factor XIII alone or...
|
|
|
RE39321 |
Supplemented and unsupplemented tissue sealants, methods of their production and use
This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds,...
|
|
|
7087721 |
Compositions, kits and treating methods for alteration cell-cell adhesion, transport, or permeation properties of tissues
The present invention relates to compositions, kits and treating methods for the alteration cell-cell adhesion, transport, or permeation properties of tissues. The present invention also relates to...
|
|
|
7087722 |
Fibrin binding domain polypeptides and uses and methods of producing same
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding...
|
|
|
7078490 |
Artificial antibody polypeptides
A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding a monobody, and a variegated nucleic acid library encoding a monobody, are provided by the invention. Also...
|
|
|
RE39192 |
Supplemented and unsupplemented tissue sealants, methods of their production and use
This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation...
|
|
|
7074402 |
Neuroprotective, antithrombotic and anti-inflammatory uses of activated protein C (APC)
The present invention provides methods for treating subjects having or at risk of having a neuropathological disorder or brain inflammatory diseases with and without vascular involvement, and...
|
|
|
7067301 |
Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human prothrombinase-like polypeptide. These...
|
|
|
7015193 |
Compositions and methods to control bleeding
Disclosed are compositions for treating blood coagulation disorders and allows for manipulation of the blood coagulation cascade. More particularly the invention, relates to compositions for...
|
|
|
7008800 |
Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
|
|
|
7009039 |
Plasma protein matrices and methods for their preparation
A freeze dried biocompatible matrix comprising plasma proteins, useful as implants for tissue engineering as well as in biotechnology, and methods of producing the matrix are provided. Mechanical...
|
|
|
7005271 |
Method for the determination of the prethrombotic state
The present invention relates to determining the prethrombotic state, in particular determining an amount or presence of circulating microparticles and/or stimulated procoagulant cells.
|
|
|
7005502 |
Pharmaceutical preparation comprising vWF propeptide
Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWf propeptide as well as a method for producing such a prepartion.
|
|
|
6965014 |
Fibrin material and method for producing and using the same
This invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium....
|
|
|
6933136 |
Method for making recombinant proteins
The invention provides nucleic acid molecules and vector constructs comprising scaffold/matrix attachment regions and methods of using such scaffold/matrix attachment regions for the industrial...
|
|
|
6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
|
|
|
6924151 |
Stable factor VIII/vWF-complex
There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation...
|
|
|
6924365 |
Optimized messenger RNA
The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The...
|
|
|
6911334 |
Protease for activating clotting factor VII
A protease for activating the blood clotting factor VII is described, wherein the protease is inhibited by the presence of aprotinin and is increased in its activity by calcium ions and/or heparin...
|
|
|
6878813 |
Human antithrombin IIIs and methods related thereto
The present invention discloses modified antithrombin III compounds and methods. The amino acid compounds of the present invention are useful in treating blood clotting disorders, as well as other...
|
|
|
6872808 |
Nematode-extracted serine protease inhibitors and anticoagulant proteins
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and...
|
|
|
6869790 |
Preparation of DNA encoding factor XIIIA
The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is...
|
|
|
6869934 |
Method of purifying calcium ion-binding protein
The present invention relates to a method for purifying a calcium ion-binding protein by cation exchange chromatography. The present invention provide a method for isolating and purifying a calcium...
|
|
|
6846910 |
Isolated proteins containing portions of FAPα and other proteins
The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or “FAPα” and its uses.
|