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6277583 |
Affinity labeling libraries and applications thereof
Novel methods and compositions are provided for preferentially bonding an oligomeric molecule to a macromolecular target where the target is a member of a complex mixture and/or there is...
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6277618 |
Recombinant blood-coagulation proteases
The invention relates to a non-glycosylated protein with enzymatic and serin protease activity, the zymogenous form thereof comprising the following domains of a protease of the factor IX family:...
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6268223 |
Assay for detecting damage to the central nervous system
A method is disclosed for the rapid diagnosis of disorders characterized by an ischemic event, such as stroke, transient ischemic attack, head trauma, myocardial infarction or other insults...
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6268344 |
Methods for treating hypercoagulable states or acquired protein C deficiency
A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans, meningococcal sepsis, bone marrow and...
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6264948 |
Methods and compositions for inhibiting tumor cell growth
A method of suppressing tumor cell growth, comprising administering to a mammal in need thereof an amount of an inhibitor of eosinophilia sufficient to result in suppression of tumor cell growth is...
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6264953 |
Method of preparation and use for zona pellucida antigens and antibodies for sterilization and contraception
The invention relates to antigenic preparations useful for inducing the production of antibodies in an individual which will bind to epitopes on zona pellucida. Also disclosed are immunogenic...
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6251867 |
Antiangiogenic peptides and methods for inhibiting angiogenesis
Mammalian kringle 5 fragments are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.
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6251370 |
Tissue adhesive suitable for spray application
An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a...
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6248564 |
Mutant MHC class I molecules
Methods of generating a conjugate of MHC class I molecule and a compound via a cysteine residue engineered into the β2-M subunit. Also featured are uses of the conjugates.
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6242419 |
Compositions isolated from stromal cells and methods for their use
Isolated polynucleotides encoding polypeptides expressed in mammalian fsn -/- lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated...
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6239101 |
Thrombin binding polypeptides
Small, buffer soluble polypeptides having amino acid structures corresponding to residues 234-486, 310-486, and 407-486, of thrombomodulin and functionally equivalent analogs thereof inhibiting the...
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6238670 |
Compositions and methods employing a ligand for CD21 or CD19 for modulating the immune response to an antigen
Described herein are compositions which modulate the immune response. In one aspect, a composition is described which comprises an antigen covalently linked to a ligand for CD21(CR2) or CD19. This...
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6239261 |
Pasteurized, purified von Willebrand factor concentrate and a process for the preparation thereof
A process for the preparation of a concentrate of von Willebrand factor is described, entailing a solution of a complex of this factor with factor VIII:C being optionally pasteurized and treated...
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6238664 |
Process for stabilizing proteins
An aqueous protein solution buffered with a potassium phosphate buffer, in which the ratio of potassium ions to sodium ions in the solution is at least 10:1, is resistant to the formation of...
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6235710 |
Spray dried erythropoietin
The present invention provides a method for preparing stable, spray dried rhEPO and the rhEPO powder produced thereby.
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6228618 |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
Methods for enhancing the production of tissue plasminogen activator (tPA) in cell culture are disclosed. The methods involve culturing tPA-producing cells in growth media supplemented with an...
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6228989 |
Peptide substrates phosphorylated by P21-activated protein kinase
The determinants for phosphorylation of substrates by γ-PAK have been identified by examining the kinetics of phosphorylation of a series of synthetic peptides. The recognition sequence for γ-PAK...
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6221657 |
Modified human C3 DNA sequences and vectors
This invention is directed to DNA sequences encoding narrative complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. The modified C3 proteins are...
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6218513 |
Globins containing binding domains
The present invention relates to globins containing non-naturally occurring binding domains, In particular, the present invention is directed toward a binding domain comprising the oligomerizing...
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6214343 |
Prevention and treatment of necrotizing enterocolitis
Methods are described for preventing and treating necrotizing enterocolitis in animals, including humans. Antibodies directed to PAF and/or TNF are shown to have a beneficial effect in animal...
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6211344 |
Process for preparing factor V-deficient plasma, and a deficient plasma which is obtained in this way
The invention relates to a process for preparing factor V-deficient plasma, in particular a factor V-deficient plasma from a starting plasma using antibodies, and a deficient plasma which is...
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6211341 |
Polypeptide having factor Xa inhibitory activity
The present invention provides an antibody which specifically reacts with an epitope of a polypeptide comprising the amino acid sequence X-Y-CYS GLN GLU GLU GLU CYS PRO ASP PRO TYR LEU CYS SER PRO...
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6191108 |
RH blood group antigen compositions and methods of use
Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments...
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6184206 |
Integrin ligand dissociators
The invention provides a method of disaggregating a ligand:integrin receptor complex. Specifically, the invention provides a method of disaggregating an existing platelet thrombus in a blood vessel...
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6183980 |
Method for locating defects in the clotting system
The present invention relates to a method for identification of defects in the clotting, fibrinolysis and complement system.
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6180610 |
Tetrapeptide
The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same...
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6180596 |
Methods of inhibiting phospholipase A2 and phospholipase A2 stimulator activities
A method for inhibiting PLA 2 or suppressing the activity of a PLA 2 stimulator in a body fluid of an animal with lung disease involves adding Annexin I, Annexin VIII or a mixture thereof to the...
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6174855 |
Pharmaceutical compositions comprising thrombin inhibitors and their use in the control of wound healing processes
There is provided the use of a thrombin inhibitor in the manufacture of a product for use in the control of wound healing processes within the body, in particular, the inhibition or prevention of...
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6160098 |
Method for control of functionality during cross-linking of hemoglobins
The present invention relates to cross-linked hemoglobins, and particularly to methods of controlling the functionality of such hemoglobins. The controlled functionalities include the P 50 and the...
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6160097 |
Process for reactivating purified membrane proteins by freezing them
A process is described for reactivating purified membrane proteins in which a mixture composed of membrane protein, a phospholipid and a detergent is frozen and subsequently thawed.
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6150331 |
Human growth hormone-containing aqueous pharmaceutical composition
Provided is an aqueous pharmaceutical composition comprising human growth hormone wherein said human growth hormone is dissolved in a benzalkonium chloride-containing, slightly to weakly acidic...
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6136580 |
β-1-6-N-acetylglucosaminyltransferase that forms core 2, core 4 and I branches
The present invention provides a substantially pure C2GnT-M polypeptide or a functional fragment or derivative thereof, wherein C2GnT-M is characterized as a polypeptide having core 2, core 4 and I...
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6121232 |
Stabilized mixture comprising fibrinogen
A stabilized solution of fibrinogen containing samples, in particular a stabilized solution of the biological active component (BAC) which is a solution of proteins derived from blood plasma...
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6117647 |
Process for quantifying glycosaminoglycans in antithrombin III-containing solutions
A process for determining glycosaminoglycans in antithrombin III (ATIII)-containing solutions by increasing the ionic strength of the AT III-containing solution until the interaction between AT III...
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6117838 |
Use of hemoglobin in the treatment of hypotension
A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.
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6114306 |
Cytokine related to hemolytic anemia and method of use
Pyruvate kinase deficiency is a blood disease characterized by hemolytic anemia. PCR analysis of cDNA leukocytic extracts of patients with hereditary pyruvate kinase deficiency anemia revealed two...
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6103691 |
Utilisation of angiogenin and/or α.sub.1 -microglobulin and/or complement factor D in order to inhibit the secretion of proteins
The invention proposes a way to generally prevent or at least severely limit the secretion of proteins, particularly the secretion of enzymes from leucocytes. By administering an agent containing...
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6096309 |
Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof
The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and...
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6093804 |
Method for purification of alpha-1 proteinase inhibitor
The methods of the present invention provide a simple means for separating active and inactive Alpha Proteinase Inhibitor (API). The methods further provide means for purifying API at high yield...
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6090779 |
Use of hemoglobin to treat septic shock
Therapeutic treatment of septic shock comprises administering to an animal stroma-free hemoglobin, typically at a dose ranging from the least amount effective to increase perfusion, up to a dosage...
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6090777 |
Method to reduce myocardial injury during acute myocardial infarction
A therapeutic or prophylactic treatment method of acute myocardial infarction, comprising administering exogenous C1-esterase inhibitor, alone or in combination with other drugs, to a patient with...
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6072072 |
Compounds for preparing modified hemoglobin
The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be...
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6069234 |
Modified coagulation agent
The present invention is directed to a modified coagulation factor Xa which has an improved capacity of forming crystals compared to its native form. Such crystals or crystalline composition are...
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6063763 |
Protease-resistant thrombomodulin analogs
The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin,...
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6046161 |
Use of hemoglobin in the treatment of cardiogenic shock
A method for increasing perfusion in a mammal suffering from cardiogenic shock by administering a perfusion-increasing effective amount of intermolecularly- or intramolecularly-crosslinked...
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6046316 |
Nucleic acid encoding truncated integrins
tr-αllb, a soluble, truncated integrin found to be exclusively expressed in tumor cells is provided. An additional truncated integrin, tr-β3, has also been found to be exclusively expressed in...
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6042833 |
Cellular internalization of pIgR stalk and associated ligands
Compositions and methods for specific binding to the stalk of a polymeric immunoglobulin receptor (pIgR) of a cell with the proviso that the ligand does not substantially bind to secretory...
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6037458 |
Adsorbent for serum amyloid protein
An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a...
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6034060 |
Peptide having an ability to promote the activation of protein C by thrombin
The peptide of the present invention comprises a specific amino acid sequence including at least 118 amino acids and has the ability to promote the activation of protein C by thrombin. The peptide...
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6024688 |
Angiostatin fragments and method of use
Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically...
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