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7612171 |
DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7601515 |
Process of high purity albumin production
A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins,...
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7572598 |
Preparation comprising albumin esterified with a labeled substance for diagnosis of pancreatic exocrine function
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into...
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7550272 |
Method for diagnosis of pancreatic exocrine function
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into...
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7495115 |
Steroid conjugates, preparation thereof and the use thereof
Conjugates comprising one or more steroids conjugated with one or more mammalian proteins are disclosed. The conjugates are useful for diagnosis or treatment of solid cancer and haematological...
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7435410 |
Methods of treatment with interferson and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7345150 |
Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions...
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7332577 |
Therapeutic human albumin solutions with low prekallikrein activator (PKA) activity and process for obtaining them
The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterised in that it has an antithrombin content...
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7271149 |
GLP-1 fusion proteins
The present invention relates to glucagon-like-1 compounds fused to proteins that have the effect of extending the in vivo half-life of the peptides. These fusion proteins can be used to treat...
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7238667 |
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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7223561 |
Process of high purity albumin production
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers...
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7220552 |
Bifunctional molecules and their use in the disruption of protein-protein interactions
Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target...
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7208580 |
Atomic structure of the hemalbumin complex and its use in designing therapeutic compounds
A high resolution structure of the hemalbumin binding complex is provided which includes the detailed atomic coordinates which reflect the binding site and the binding characteristics of the...
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7202041 |
Immunoreaction measurement method
The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one...
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7198949 |
Compositions and methods for altering the biodistribution of biological agents
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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7182962 |
Immunostimulator for animals and humans, and method of preventing animal and human infectious diseases and cancer
The goal of the present invention is to provide substances to prevent diseases by activating inherently possessed functions, for cultured fishes and shellfishes and livestock with tendency of...
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7163919 |
Anticancer composition
The present invention relates to an anticancer composition comprising a therapeutically effective amount of one or more active components selected from the group consisting of citric acid; citric...
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7141547 |
Albumin fusion proteins comprising GLP-1 polypeptides
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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7129210 |
Tissue adhesive sealant
A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive...
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7115583 |
Microbubble compositions and methods for oligonucleotide delivery
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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7112563 |
Therapies using hemoproteins
Herein it is shown that hemoproteins (e.g., Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities. The invention provides a method of reducing the...
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7105160 |
Antibody-serum protein hybrids
Hybrid proteins are described which comprise one or more antigen-binding antibody fragments covalently linked to one or more serum carrier proteins. The hybrid proteins can bind antigens, have a...
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7094577 |
Insulin and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7087719 |
Method for the crystallization of human serum albumin
The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process...
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7081354 |
Interleukin and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7078378 |
Method of tissue repair II
A substantially solid biomolecular solder for joining tissue comprising a partially denatured biomolecule. The solder can be formed into shapes to suit the needs of a user. The invention also...
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7057019 |
Crosslinked albumin hydrogels
Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an...
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7056701 |
Hormone and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7041478 |
G-CSF and albumin fusion protein
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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7026453 |
Method of protein purification
Purification methods are provided for proteins and peptides, employing silicon carbide to bind the proteins or peptides. The methods may also be used to recover and purify recombinantly expressed...
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7005506 |
Method for preparing an albumin isolate from a substance containing albumin
For preparing an albumin isolate from a substance containing albumin, the substance is first ground to a flour. The flour is then suspended in an aqueous solution. The albumin is extracted from the...
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6987006 |
Erythropoietin and albumin fusion protein, nucleic acids, and methods thereof
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6936423 |
Anti-LTNF for in vitro assay of biological toxins
Lethal Toxin Neutralizing Factor has been isolated in purity from opossum serum by high pressure liquid chromatography (HPLC) fractionation. The amino acid sequence from the N-terminal for the...
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6867193 |
Amino acid-containing albumin preparation
An albumin preparation that prevents onset of hepatic encephalopathy caused by conventional amino acid preparations and enhances an effect of improving the symptoms is provided. The albumin...
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6846299 |
Method for continuous recirculating peritoneal dialysis
Method for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a continuous process basis a...
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6693173 |
Method to remove citrate and aluminum from proteins
A method is provided for removing citrate, aluminum, and other multivalent ions and contaminants from proteins by adjusting the pH of a solution containing the protein to a pH from about 7 to about...
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6693169 |
Laminin 5, 13 and 14 and uses thereof
The present invention features two members of laminin family, i.e., laminin 13 and laminin 14, the methods of making these molecules, and the methods of using these molecules in treating neural...
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6620778 |
Cysteine/glycine rich peptides
Described is a method for the preparation of a mixture of peptides having a cysteine content between 7-20 w/w % from a protein source, comprising cysteine containing proteins, comprising the steps...
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6613884 |
Method for the removal/purification of serum albumins and means for use in the method
A method for removing a serum albumin from a mixture of other compounds by contacting said mixture with a ligand a) having affinity for and enabling selective binding of the serum albumin and b)...
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6610825 |
Method for alleviating pain or providing an analgesic effect in a patient
Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said...
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6602981 |
Antinociceptive agent derivative
Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said...
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6500918 |
Conjugate comprising an antinociceptive agent covalently bonded to a blood component
Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said...
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6500800 |
Composition and method for causing photodynamic damage to target cells
The present invention is directed to a composition for causing photodynamic damage to target cells comprising a photosensitiser, a photosensitiser carrier component, a component which enables...
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6489443 |
Process for the preparation of a protein solution
A process for the preparation of a protein solution is described which is not prone to flock or particle formation even on heat treatment, the heat treatment being carried out in a glass vessel...
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6485935 |
Structure of the ankyrin binding domain of a α-Na, K-ATPase
The present invention provides a polypeptide of 26 amino acid residues that comprises the minimal ankyrin binding (MAB) domain. The MAB domain is responsible for the interactions between a...
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6458758 |
Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular,...
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6429297 |
Modified avidin and streptavidin and methods of use thereof
The present invention relates to a compound of the formula These modified streptavidin compounds have are useful as part of a delivery system to deliver a molecule to a target site for use in...
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6429294 |
Peritoneal dialysis fluid and method for a continuous recirculating peritoneal dialysis using the same
A peritoneal dialysis fluid used for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a...
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6410695 |
Individual medicament dosing conjugate
The present invention relates to a conjugate comprising an active substance and a compound having a binding site for metallic compounds. In addition, this invention relates to a process for the...
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