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7608578 |
Obesity controlling method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding...
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7595377 |
Substantially non-immunogenic injectable collagen
The invention provides an article of manufacture comprising a substantially non-immunogenic injectable collagen for implantation into humans. The invention further provides methods for preparing...
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7591841 |
Implantable devices for accelerated healing
Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
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7579442 |
Method for stromal corneal repair and refractive alteration
A method and means of providing stromal repair and improved refractive correction by creating corneal stromal collagen tissue with fibril diameter and spacing that duplicates the optical...
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7560432 |
In situ method for treatment and repair of meniscal injuries
A method for in situ repair of meniscal injuries comprising induction of meniscal repair and regeneration by introducing an adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury...
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7544781 |
Polypeptide and process for producing the same
A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound...
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7544780 |
Prokaryotic collagen-like proteins and uses thereof
The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a...
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7544368 |
Structure for modulating intraocular pressure
Embodiments of the present invention are directed to three-dimensional porous structures for modulating intraocular pressure. The structures can include a mixture of copolymers, for example,...
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7498412 |
Process for preparing porous collagen matrix from connective tissue
The subject invention provides a process for preparing a porous collagen matrix from connective tissue, said process comprising: a porous structure forming step to treat said connective tissue with...
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7498299 |
Procollagen (III) propeptides and related substances for treating fibrotic diseases
In a method of treating a fibrotic disease, a composition is administered to a mammal an effective amount, wherein the composition contains a polypeptide selected from the group consisting of rat,...
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7495076 |
Mineral collagen chelates and methods of making and using same
Collagen peptide chelated mineral products, pharmaceutical formulations thereof and methods for preparing same are provided. Also provided is a method for generating the optimal size of collagen...
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7494664 |
Composite biomaterials
This invention provides novel composite biomaterials having excellent bioadaptability and bone inductivity and a process for producing the same. The composite biomaterials comprise hydroxyapatite,...
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7459541 |
Matrix-targeted fusion polypeptides for tissue regeneration and wound healing
The present invention relates to compositions and methods for promoting tissue repair and regeneration. The invention provides a fusion polypeptide useful for targeting tissues for regeneration and...
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7452684 |
Collagen XXII, a novel human collagen and uses thereof
The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid...
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7410947 |
Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
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7410770 |
Method for monitoring collagen type II degradation in cartilage
A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in...
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7396912 |
Collagen production method
The present invention relates to a novel collagen production method wherein the collagen-containing tissues are fermented to extract the collagen. The fermentation process employs microorganisms,...
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7393649 |
Detection of specific nitrated markers
Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease,...
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7393437 |
Photochemically crosslinked collagen scaffolds and methods for their preparation
A method for producing collagen-based scaffolds with improved characteristics, which broadens the usage of collagen in tissue engineering and the products so produced are described. The method...
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7374774 |
Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers
The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more...
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7348005 |
Oral tolerance induction by collagen to prevent allograft rejection
The present invention relates to the use of collagen and MHC-like compounds to down regulate immune responses. Methods for administration of such compounds that induce immune tolerance are...
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7345158 |
Actin related cytoskeletal protein “LACS”
The present invention provides the novel L-NAME-related actin cytoskeletal protein (LACS) and genes encoding the protein.
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7320962 |
Hemoactive compositions and methods for their manufacture and use
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a...
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7285638 |
Method of obtaining biologically active collagen from skins of the salmonidae fish
The method of obtaining collagen as above, is characterized by this, that the process of cleaning the skins is done manually using tools made of natural materials such as glass and wood to remove...
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7279329 |
Expression system for producing collagen
A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems...
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7250397 |
Antiarrhythmic peptides
Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions...
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7241871 |
Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof
The present invention relates to a process for the production of marine invertebrate type V telopeptide containing collagen preparations from marine invertebrates, compositions containing...
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7232886 |
Method for the manufacture of recombinant unhydroxylated collagen polypeptide fibres, and recombinant unhydroxylated collagen polypeptide fibres obtained thereby
The present invention relates to a process for the production of fibres of an unhydroxylated recombinant collagen polypeptide, and the fibres obtained thereby, as well as to uses of such fibres as...
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7229971 |
Regulation of biodegradability of composite biomaterials
This invention relates to a method for regulating the biodegradability of composite biomaterials comprising calcium salt (particularly hydroxyapatite) and collagen, improved composite biomaterials...
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7229634 |
Engineered proteins, and methods of making and using
The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.
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7223834 |
Assays and peptide substrate for determining aggrecan degrading metallo protease activity
This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates...
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7214765 |
High density fibrous polymers suitable for implant
This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a...
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7214654 |
Agent for the manufacture of biological parts including an active ingredient complex and carrying materials suitable for the active ingredient complex
The invention concerns a means for the at least partial production of reproduction of biological parts, especially or organs for living beings in which a carrier with an active ingredient complex...
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7186806 |
Process for producing regenerated collagen fiber and process for setting the same
The present invention relates to a process for preparing regenerated collagen fiber which comprises treating regenerated collagen fiber with a monofunctional epoxy compound and a metal aluminum...
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7183383 |
Uses of collagen IV
The present invention provides a method of recovering cellular functions in cells following injury, comprising the step of contacting said cells with collagen IV or a natural or mutated fragment...
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7179885 |
Silver-dispersing polypeptides
Silver halide emulsions for photographic uses contain a nucleation peptiser having at least one region A of up to 100 amino acids. Region A can either consist of (i) at least two silver-binding...
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7157428 |
Method for treatment and repair of meniscal injuries
A method for repair of meniscal injuries comprising induction of meniscal regeneration by introducing a strongly adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury.
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7153938 |
Cross-linked apatite/collagen porous body containing self-organized apatite/collagen composite and its production method
A method for producing a cross-linked apatite/collagen porous body comprising the steps of gelling and then freeze-drying a dispersion containing an apatite/collagen composite and collagen to form...
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7129210 |
Tissue adhesive sealant
A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive...
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7129209 |
Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions
The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that...
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7122521 |
Collagen mimics
A novel collagen mimic comprising a tripeptide unit having the formula (flpYaaGly) n , where flp is 4(S)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the...
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7119062 |
Methods and compositions for improved articular surgery using collagen
The invention provides methods for treating post-surgical articular or incisional pain and/or discomfort in a patient. The invention further provides improved surgical methods and controlled...
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7109300 |
Extraction of collagen from calcified tissues
A method is disclosed for extracting collagen from calcified tissue without a prior decalcification step. The method may be used with calcified tissues such as fish skin with scales, alligator...
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7105182 |
Periodontal regeneration composition and method of using same
A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. All particles are sized to be less than...
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7098315 |
Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge
A method of preparing a collagen sponge comprises mixing air into a collagen gel, so as to obtain a collagen foam which is dried. From the dried product thereby obtained, collagen sponge is...
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7094580 |
Methods for producing pure perlecan and other heparan sulfate proteoglycans
A method of perlecan isolation (from the EHS tumor) which produces “clean” (i.e. substantially “pure”) perlecan is disclosed. Clean perlecan is thus produced in sufficient quantities for...
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7091180 |
Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same
Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue...
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7078068 |
Methods for coagulating collagen using phosphate brine solutions
Methods for coagulating collagen and producing a food product by contacting the collagen with a solution comprising at least about 40% by weight of a phosphate salt mixture wherein the phosphate...
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7074901 |
Isolated human vCOL16A1 polypeptide and fragments thereof
The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers,...
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RE39172 |
Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in...
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