|
Match
|
Document |
Document Title |
|
|
5817764 |
Cell culture substrates and methods of making such substracts
Cell culture substrates comprising dried films of native fibrillar collagen produced by a method in which collagen fibers are hydrolyzed in acid, solubilized, and reformed as gels on porous...
|
|
|
5814328 |
Preparation of collagen using papain and a reducing agent
Purified collagen is produced by contacting a collagen sample with a first proteolytic enzyme, a reducing agent and a second proteolytic enzyme. Preferably, the first and second proteolytic enzymes...
|
|
|
5810970 |
Paper strengthened with solubilized collagen and method
A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction...
|
|
|
5808012 |
Protein-enriched thermoplastics
Thermoplastics interdispersed with a variety of functional thermostable proteins and methods for their production are provided. To prepare the subject thermoplastics, a plastic material is...
|
|
|
5800541 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction
The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a...
|
|
|
5801045 |
Collagen-like polypeptides and biopolymers and nucleic acids encoding same
Synthetic biopolymers can be prepared using recombinant DNA technology or chemical synthetic methods which have properties similar to naturally occuring gelatin or collagen. These materials...
|
|
|
5800542 |
Sterilization by gamma irradiation
A method of treating a reconstituted biopolymeric implant which includes the steps of exposing the implant to an aqueous environment so that a final water content of the implant ranges from 5% by...
|
|
|
5785983 |
Non-porous collagen sheet for therapeutic use, and the method and apparatus for preparing it
Type I collagen gel with an H 2 O content not exceeding 20% by weight, in the form of a sheet of thickness between 0.02 and 2 mm, of compact transparent structure, with a capacity for absorbing...
|
|
|
5773248 |
Nucleic acid encoding a human α3(IX) collagen protein and method of producing the protein recombinantly
The present invention relates to novel collagens and polynucleotide sequences encoding these novel proteins. The present invention further relates to specific collagens and derivatives,...
|
|
|
5773577 |
Products comprising substrates capable of enzymatic cross-linking
Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences, capable of enzyme catalyzed...
|
|
|
5773249 |
High molecular weight collagen-like protein polymers
Collagen-like polymers having repetitive triads are produced having reduced proline content, where glycine is the initial amino acid and the subsequent amino acids are varied, while retaining at...
|
|
|
5763579 |
Collagen derivatives, process for producing them and their application to the preparation of biomaterials
The present invention relates to a modified collagen which is soluble in water and/or in aprotic polar organic solvents and which comprises free or substituted thiol functional groups carried by...
|
|
|
5763272 |
Hybridoma for producing antibody for collagen I
Disclosed are antibodies which specifically bind the amino acid sequence of SEQ ID NO. 1 of collagen I. A hybridoma cell line which produces the antibodies is also disclosed.
|
|
|
5763583 |
Process for producing solubilized protein
A process for the production of a solubilized protein is disclosed, which is obtained by reducing disulfide bonds in a disulfide bond-containing water-insoluble protein material into mercapto...
|
|
|
5756678 |
Prion inactivation in connective tissue materials
It has been discovered that it is possible to treat solutions of connective tissue material for the inactivation of prions in a manner such that connective tissue molecules are not adversely...
|
|
|
5750647 |
Synthetic peptide analogs of NTx
Synthetic linear peptides embodied by Y-Tyr-Asp-Gly-X-Gly-Val-Gly (SEQ ID NO:1) which mimic the epitope recognized by mAb 1H11 (ATCC No. HB 10611) in cross-linked N-telopeptides of type I collagen...
|
|
|
5741895 |
Identification of cell density signal molecule
Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to...
|
|
|
5739286 |
Bone augmentation material
There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to...
|
|
|
5733339 |
Process for fixation of calcification-resistant biological tissue
A process is provided for non-glutaraldehyde fixation of an organ or prosthesis to be implanted in a mammal. The process produces stable fixation of the tissue by forming amide linkages within and...
|
|
|
5731418 |
Collagen-based sorbent polymer and method of preparing same
A modified collagen product adapted for use as a sorbent is provided which includes collagen polymer having a density of from about 0.2-1.3 g/ml, an intrafibril pore size of from about 25-150...
|
|
|
5731417 |
Cell culture substrates and method of making
Cell culture substrates comprising dried films of native fibrillar collagen produced by a method in which collagen fibers are hydrolyzed in acid, solubilized, and reformed as gels on porous...
|
|
|
5726243 |
Mild solid-phase synthesis of aligned, branched triple-helical peptides
A triple-helical polypeptide of the formula: ##STR1## is provided wherein: Z is Hyp or Pro; each X and Y is an amino acid such that (Gly-X-Y) m is a sequence of a collagen cell adhesion site; said...
|
|
|
5714582 |
Invertebrate type V telopeptide collagen, methods of making, and use thereof
This invention relates to a method and process for the production of collagen preparations from marine invertebrates and compositions for these preparations. The collagen preparation includes...
|
|
|
5711853 |
Paper strengthened with solubilized collagen and method
A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction...
|
|
|
5710252 |
Method for recombinant yeast expression and isolation of water-soluble collagen-type polypeptides
A method for preparing and purifying collagen-type polypeptides (or biopolymers) has been developed. The polypeptides are prepared by recombinant DNA technology using yeast host cells. Once...
|
|
|
5707962 |
Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may...
|
|
|
5705163 |
Target-specific, cytotoxic, recombinant pseudomonas exotoxin
A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near...
|
|
|
5705488 |
Injectable compositions for soft tissue augmentation
Injectable implant compositions for soft tissue augmentation comprise elastin and collagen and a biocompatible carrier. An injectable implant composition for soft tissue augmentation is derived...
|
|
|
5703211 |
Collagen finings and preparation thereof
The present invention relates to a process for preparing collagen finings. The process comprises providing collagen in the form of undried fish isinglass which has been freshly prepared or frozen,...
|
|
|
5686115 |
Poly-β-1➝4-N-acetylucosamine copolymer composition with collagen
The present invention relates to a purified, easily produced poly-β-1➝4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in collagen copolymers. The p-GlcNAc of the invention is a...
|
|
|
5686425 |
Composition and method for revitalizing scar tissue
A composition and method are provided that are effective in revitalizing scar tissue by introducing a bioactive substance having angiogenic activity into the scar tissue. The bioactive substance...
|
|
|
5677284 |
Charged collagen particle-based delivery matrix
A collagen-based delivery matrix including collagen particles, wherein each of the particles has a diameter between 5 μm and 850 μm and, when suspended in an aqueous solution at a pH of about...
|
|
|
5674290 |
Water-stabilized biopolymeric implants
A method of treating a reconstituted biopolymeric implant which includes the steps of exposing the implant to an aqueous environment so that a final water content of the implant ranges from 5% by...
|
|
|
5670369 |
Method for the production of soluble collagen
The invention includes an improved method for producing an aqueous solution of soluble collagen. The method comprises the steps of: (A) providing an aqueous ground slurry of insoluble collagen...
|
|
|
5668107 |
Compositions and methods for inhibiting elastase
This invention provides a compound comprising: (1) a polypeptide moiety having a) an identifying number of amino acids for SPAAT, b) an elastase binding activity; and (2) an...
|
|
|
5656728 |
Human ostoclast-specific and -related genes
The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also...
|
|
|
5654135 |
Biomaterial based on collagen and its application
Biomaterial based on collagen comprises, intimately associated, a support forming a dermal substitute, said support comprising a layer based on type IV collagen and an epidermal epithelium having...
|
|
|
5647957 |
Method of preparing paper strengthened with solubilized collagen
A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction...
|
|
|
5643783 |
Collagen and uses therefor
The invention features a novel collagen, type α1 (XVIII) collagen, and uses therefor.
|
|
|
5629176 |
Human Kunitz-type protease inhibitor variants
A variant of the C-terminal Kunitz-type protease inhibitor domain of the α3 chain of human type VI collagen, the variant comprising the following amino acid sequence X 1 X 16 Asp Ile Cys Lys Leu...
|
|
|
5616471 |
Effects of growth factors on hair follicle cell proliferation and release of collagenolytic factors
The present invention relates to methods for detecting the effects of selected growth factors and pharmaceuticals on the growth and development of hair follicles by assaying hair follicle cell...
|
|
|
5616689 |
Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation
In accordance with the present invention, stabilized dispersions of collagen fibers that have been treated in order to inactivate infectious agents and methods of stabilizing such collagen fibers...
|
|
|
5605938 |
Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the...
|
|
|
5602002 |
Process for the production of low-chromium protein hydrolyzates
Described is the chemical hydrolysis of partial hydrolysates obtained by the enzymatic decomposition, in aqueous conditions in the presence of alkaline-earth oxides or hydroxides, of...
|
|
|
5597578 |
TGF-β protein compositions for inhibition of cell proliferation
Antiproliferative compositions are provided which are capable of sustained release of an antiproliferative agent, particularly a TGF-β, at a site proximal to a target cell. The compositions are...
|
|
|
5593859 |
Synthesis of human procollagens and collagens in recombinant DNA systems
The invention is transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and...
|
|
|
5567806 |
Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane, and such a membrane
Suturable, biocompatible, control-resorbing membranes are disclosed for use in guided tissue regeneration, comprising a cross-linked collagen material either obtained by crosslinking a starting...
|
|
|
5558875 |
Method of preparing collagenous tissue
A process of preparation of a collagenous prosthesis for removing cell membrane proteins from a biological collagenous tissue and preserving elasticity of the collagenous prosthesis comprises the...
|
|
|
5532217 |
Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to...
|
|
|
5531791 |
Composition for repair of defects in osseous tissues, method of making, and prosthesis
A biocompatible collagen/demineralized human bone composite material, method for making the same, and prostheses employing the same are disclosed, wherein the composite material may be formulated...
|