Matches 151 - 200 out of 522 < 1 2 3 4 5 6 7 8 9 10 11 >
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6117979 Process for making a bioprosthetic device and implants produced therefrom  
Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining...
6096309 Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof  
The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and...
6093803 Method of producing aminoterminal propeptide of type 1 procollagen  
Aminoterminal propeptide of type I procollagen exists in serum in two forms: classical type I procollagen which is a heterotrimer containing two pro α1-chains and one pro α2-chain of type I...
6090915 Collagen or gelatin crumble composition and uses  
An animal collagen or gelatin based crumble, and processes for the preparation of the particulate crumble, are useful in the preparation of collagen or gelatin based compositions. The crumble is...
6090920 Aminoterminal propeptides of typed 1 procollagen  
Aminoterminal propeptide of type I procollagen exists in serum in two forms: classical type I procollagen which is a heterotrimer containing two pro α1-chains and one pro α2-chain of type I...
6087090 Methods for predicting drug response  
Methods are provided for formulating models for predicting whether subjects will respond to a particular drug or treatment regimen. Biochemical profiles are obtained (by measuring a variety or...
6060255 Type IV collagen high molecular form and production and diagnostic use thereof  
A type IV collagen high molecular form having a higher molecular weight than the 7S domain of type IV collagen and including the 7S domain in its structure, is obtained from the supernatant being...
6048705 Sandwich immunoassays for collagen type I degradation products  
Sandwich immunoassays for detecting analyte indicative of type 1 collagen resorption in vivo, by contacting a body fluid sample with a first antibody and a second antibody such that analyte present...
6046164 Therapeutic agent for diseases of periodontal tissue  
6037139 System for assaying modulators of procollagen maturation  
Potential modulators of a procollagen-cleaving enzyme are assessed by determining the ability of the enzyme to cleave procollagen in the presence and absence of a potential modulator in the culture...
6037144 Method of preparing a biological material for use in ophthalmology  
A collagen containing substrate comprising cattle basal membrane is conditioned by incubating the membranes in a mixture of pepsin, hyaluronidase and acetic acid and separating the collagen from...
6025327 Hydrolyzed collagen type II and use thereof  
Hydrolyzed collagen type II powder compositions, method of preparing the compositions and use of the compositions in treating cartilage defects. The compositions are orally administered to an...
6025144 Immunoassay test kit for measuring bone resorption  
An immunoassay test kit including an immunological binding partner that binds to lysyl pyridinoline, for analyzing a body fluid sample for bone resorption in vivo.
6022722 Renaturation of proteins  
The invention relates to a method for the renaturation of denatured proteins in which they are treated with a renaturant which has on vicinal carbon atoms a hydroxyl group and at least one fluorine...
6020326 Method for inhibition of bone growth by anionic polymers  
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the...
6020200 Encapsulation compositions and methods  
The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a...
6004943 Protein-coated medical substrates for local delivery of genes and method of forming coatings on the substrates  
This invention is directed to an article, such as a medical device, for local delivery of genes. The article comprises a substrate coated with a cross-linked protein. The invention is also directed...
5994311 Cell adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other  
The invention relates to adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other and their use to promote or inhibit the cell/cell adhesion of eukaryotic cells....
5986050 Peracylated proteins and synthetic polypeptides and process for making the same  
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or...
5973112 Collagen mimics  
A novel collagen mimic comprising a tripeptide unit having the formula (XaaFlpGly) n , where Flp is 4(R)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the...
5972623 Collagen-peptide assay method  
The invention includes a method of determining the level of Type I collagen fragments in a biological fluid using an antibody which is immunospecific for an epitope contained in one of the...
5973120 α-3 chain type IV collagen polypeptides  
An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous...
5968568 Enzyme preparation for use in the binding of food materials and process for producing bound food  
An composition containing transglutaminase and collagen. The composition can be used to prepare bound food, preferably without the use of allergy-causing casein proteins.
5962025 Method for treatment of systemic sclerosis and related fibrotic diseases  
The present invention is directed to a method and pharmaceutical formulations for the treatment of systemic sclerosis in mammals, by oral administration of collagen, including type I collagen, or...
5955438 Collagen-based matrix  
A collagen matrix comprise collagen fibrils which are cross-linked to one another by a reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in...
5955578 Polypeptide-polymer conjugates active in wound healing  
A conjugate of a synthetic polypeptide containing RGD or (dR) GD and a biodegradable polymer, such as hyaluronic acid or chondroitin sulfate is disclosed. Methods of making the conjugate and using...
5952224 Selection of cells having increased cell adhesion properties  
A method for selecting cell lines expressing increased cell adhesion properties or promoting cell differentiation by culturing cells in increasing concentrations of adhesion ligand containing...
5948766 Use of tasteless, hydrolyzed collagen and agent containing the same  
Tasteless, hydrolyzed collagen from gelatin, gelatin or animal collagenic connective tissue having an average molecular weight of from 1 to 40 kD for the preparation of agents for the treatment of...
5936035 Biocompatible adhesive compositions  
Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a...
5935168 Glutaraldehyde-fixed bioprostheses  
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate there propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and...
5928922 α2 subunit of prolyl-4-hydroxylase, nucleic acid sequences encoding such subunit and methods for producing the same  
The present invention relates to novel isoforms of the α subunit of prolyl-4-hydroxylase, polynucleotide sequences encoding these novel proteins, and methods for making such proteins.
5928635 Process for producing active agent complexes  
The invention relates to a process for producing active agent complexes from at least one initial complex having components in which the initial complex is caused at least partially to assume a...
5925736 Collagen-based methods and formulations for the treatment of arthritis  
The invention provides novel methods and compositions for the treatment of immune system-mediated arthritis, including rheumatoid arthritis. The subject compositions comprise one or more different...
5908784 In vitro chondrogenic induction of human mesenchymal stem cells  
Disclosed are a composition of chemically defined components which support the in vitro chondrogenesis of mesenchymal progenitor cells, a method for in vitro chondrogenic induction of such...
5908921 Method of manufacturing gelatin  
The present invention is a process for the manufacture of gelatin which includes providing a collagen containing material and demineralizing the collagen containing material to produce ossein. The...
5891850 Saccular collagen and compositions and methods for making and using the same  
A substantially purified saccular collagen protein and compositions, including pharmaceutical compositions, that comprise the saccular collagen protein are disclosed. Methods of using the saccular...
5874006 Aseptic collagen concentration process  
A process for the aseptic concentration of collagen from about 0.25% (w/w) suspensions to gels of 15% using vortex flow filtration with a variety of membrane types--ultrafiltration and...
5874537 Method for sealing tissues with collagen-based sealants  
Collagen-based compositions as adhesives and sealants for medical use and preparation thereof are described. Prior to polymerization, soluble or partially fibrillar collagen monomers in solution...
5869277 Method for measuring type IV collagenase  
The present invention relates to the development of a modified substrate capture immunoassay useful in the detection of a neutral metalloproteinase enzyme, type IV collagenase. Capture and...
5869044 Method for the treatment or prophylaxis of ischemia-reperfusion injury  
Medicaments for the treatment or prophylaxis of ischemia-reperfusion injury in myocardial ischemia and cerebral ischemia, characterized in that the medicament contains batroxobin as an effective...
5856446 Method of treating rheumatoid arthritis with low dose type II collagen  
A method for suppressing autoimmune response in an afflicted joint in a human. The method involves oral administration of between about 5 and 25 μg per day of type II collagen.
5855620 Matrix substrate for a viable body tissue-derived prosthesis and method for making the same  
Disclosed is a process for treating body tissues such as vascular structures to remove barriers to recellularization before and after implantation in a human host. The body tissue, for example a...
5856308 Artificial collagen  
The invention provides artificial collagen comprising a stabilized ordered triple helix of copolypeptide strands containing repeating amino acid triads. The collagen may be modified with groups...
5854397 Processs for cross-linking collagenous material  
The present invention relates to a process for cross-linking a proteinaceous material. The process comprises: i) soaking the material to be cross-linked in an agueous solution of high osmolality;...
5844098 Reconstituted platelet membrane vesicles  
A reconstituted platelet membrane vesicle preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from either synthetic sources...
5840848 Method for preparation of type II collagen  
An method is disclosed for removing Type I collagen-containing tissue adjoining Type II collagen-containing animal tissue comprising treatment of unprocessed Type II collagen-containing tissue in...
5840849 Blends of collagen type I and collagen type III for food casings  
Blends of collagen type I and collagen type III having crosslinks of the pyridinoline (Pyrid), dihydroxylysinonorleucine (DHLNL) and histidinohyroxylysinonorleucine (HHL) types, wherein the amounts...
5834593 Soluble form of PrP.sup.SC which is insoluble in native form  
The invention includes deleting codon segments from DNA expressing a native protein (e.g., PrP Sc ) in order to obtain a shorter, soluble protein which mimics characteristics of an insoluble native...
5830859 Complex for inducing bone growth in the maxillary sinus  
A protein complex for inducing growth of bone in the maxillary sinus of an animal is disclosed. The complex is generally made from animal bone, defated, demineralized, ground, slurried, and...
5817755 Synthetic peptide analogs of cross-linked N-telopeptides of type I collagen  
Synthetic linear peptides embodied by Xaa-Tyr-Xaa-Gly-Xaa-Gly-Val-Gly which mimic the epitope recognized by mAb 1H11 (ATCC No. HB 10611) in cross-linked N-telopeptides of type I collagen (NTx).
Matches 151 - 200 out of 522 < 1 2 3 4 5 6 7 8 9 10 11 >