Matches 101 - 150 out of 522 < 1 2 3 4 5 6 7 8 9 10 11 >
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6432706 Method for inhibiting angiogenesis and tumors with the isolated NC1 α6 chain monomer of type IV collagen  
The instant invention provides methods and kits for inhibiting angiogenesis, tumor growth and metastasis, and endothelial cell interactions with the extracellular matrix, involving contacting the...
6428978 Methods for the production of gelatin and full-length triple helical collagen in recombinant cells  
Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are...
6426075 Protease-activatable pseudomonas exotoxin A-like proproteins  
This invention provides protease-activatable Pseudomonas exotoxin A-like (“PE-like”) proproteins. The proproteins comprise (1) a cell recognition domain of between 10 and 1500 amino acids that...
6423513 Polynucleotides encoding protease-activatable pseudomonas exotoxin a-like proproteins  
This invention provides protease-activatable Pseudomonas exotoxin A-like (“PE-like”) proproteins. The proproteins comprise (1) a cell recognition domain of between 10 and 1500 amino acids that...
6423315 Synthetic peptide for treatment of autoimmune arthritis  
Peptides that are capable of suppressing autoimmune arthritis are disclosed. The polypeptides described by the present invention which are capable of suppressing autoimmune arthritis in mammals...
6413742 Recombinant gelatin and full-length triple helical collagen  
Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are...
6391861 Method for the prevention of tissue elastic fiber injury  
The subject invention is directed to the prevention of elastic fiber injury by administering HA or any other polysaccharide or carbohydrate moiety that binds to and coats elastic fibers, thereby...
6384197 Process for the preparation of mineralized collagen fibrils and their use as bone substitute material  
The invention relates to a process for the preparation of mineralized collagen fibrils, where the fibril formation and mineralization take place in one process step, and to the use thereof as bone...
6372442 Method of characterizing the degradation of type II collagen  
Methods of characterizing the degradation of type II collagen in body fluids are disclosed. In a specific method, a sample of body fluid is subjected to at least two distinct immunological assays,...
6355442 METHOD OF ASSAYING COLLAGEN FRAGMENTS IN BODY FLUIDS, A TEST KIT AND MEANS FOR CARRYING OUT THE METHOD AND USE OF THE METHOD TO DIAGNOSE THE PRESENCE OF DISORDERS ASSOCIATED WITH THE METABOLISM OF COLLAGEN  
A method of assaying collagen fragments in body fluids, including bringing a sample of body fluid in contact with at least one immunological binding partner for the collagen fragments, said binding...
6350732 Method for extracting lipids from tissue samples using high osmolality storage medium and product  
A method extracting lipids from tissue samples, particularly collagenous tissue samples for use in preserving the tissue samples, is disclosed. The product of the method of extracting the lipids is...
6346515 Collegan-based matrix  
A collagen matrix comprises collagen fibrils which are cross-linked to one another by reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in...
6344437 Medicine drink food and feed having an action of strengthening bone  
The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or...
6333304 Therapeutic compositions containing glucosamine, collagen and a bioflavanol for repair and maintenance of connective tissue  
A composition for treating arthroses in animals includes exogenous glucosamine, hydrolyzed collagen and a bioflavanol. Preferred glucosamines are glucosamine hydrochloride (HCI) and glucosamine...
6329506 Template-assisted triple helical collagen-like structures  
Synthetic collagen in triple helical conformation and comprising amino acid chains of repeating trimers of highly populated collagen sequences as well as those sequences wherein the proline or...
6323319 Method of making hydrolyzed collagen type II  
Hydrolyzed collagen type II powder compositions, method of preparing the compositions and use of the compositions in treating cartilage defects. The compositions are orally administered to an...
6310036 High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces  
Disclosed is a novel tissue adhesive technology comprising a combination of ultrasonically treated proteins including collagen and albumin which form a viscous material that develops adhesive...
6300062 Enamel matrix related polypeptide  
The invention relates to novel nucleic acid fragments encoding polypeptides which are capable of mediating contact between enamel and cell surface. The invention also relates to expression vectors...
6300083 Assaying D-amino acids in body fluids  
The rate of degradation in vivo of a body protein is determined by measuring the amount of a D-amino acid containing fragment of the protein in a body fluid using an antibody capable of...
6277600 Trimeric chimera protein and collagen matrix containing chimera protein  
Provision of a trimeric chimera protein which has sufficiently retained physiological activity of a physiologically active peptide simultaneously with fibril-forming ability of a collagen. A...
6271350 Fish collagen and method of producing same  
A collagen is extracted and produced from a raw fish skin through the steps: a salt admixing step for admixing a salt (e.g. NaCl, KCl or the like) with a raw fish skin so as to allow non-collagen...
6254986 Peracylated protein-based sutures and fabrics and process for making the same  
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or...
6242573 Method of producing water-insolubilized regenerated collagen fiber  
A regenerated collagen fiber is subjected to water-insolubilizing treatment with a monofunctional epoxy compound to produce a water-insolubilized regenerated collagen fiber which can substantially...
6218360 Collagen based biomaterials and methods of preparation and use  
This invention comprises purified native state Type VI collagen/βig, Type VI-βig collagen gel, including the crosslinked gel, and the use of the gel in fibrosis limited wound healing, and methods...
6210902 Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen  
The fragmentation pattern of collagen, especially of type 1, as reflected in breakdown products of collagen in a body fluid such as serum or urine is estimated by measuring the levels of such...
6207394 Diagnosis of primary congenital glaucoma  
Methods of diagnosing primary congenital glaucoma, by detecting particular mutations in a human cytochrome P4501B1 (CYP1B1) gene, are disclosed. Methods include hybridization analysis, such as...
6204367 Elisa kit for quantification of C-terminal telopeptides of type I collagen in human serum  
An enzyme linked immunosorbent assay (ELISA) kit for the quantification of degradation products of carboxy-terminal telopeptides of type I collagen in a human serum sample, including an antibody...
6204365 Collagen modulators for use in photoablation eximer laser keratectomy  
A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making...
6197935 Prion-free collagen and collagen-derived products and implants for multiple biomedical applications; methods of making thereof  
The use of collagen as a biomedical implant raises safety issues towards viruses and prions. The physicochemical changes and the in vitro and in vivo biocompatibility of collagen treated with heat,...
6190886 Trimerizing polypeptides, their manufacture and use  
Polypeptides comprising a collectin neck region, or variant or derivative thereof or amino acid sequence having the same or a similar amino acid pattern and/or hydrophobicity profile, are able to...
6187907 Triple helix coil template having a biologically active ligand  
A template-ligand conjugate including (1) a template made of three cross-linked polypeptide chains, wherein the three polypeptide chains each contain tripeptide or hexapeptide repeat sequences...
6183498 Methods and products for sealing a fluid leak in a tissue  
Methods and products for rapidly sealing a fluid leak in a tissue are provided. A polymerizable protein is applied to a tissue having an opening which creates a fluid leak in the tissue, in order...
6180606 Compositions with enhanced osteogenic potential, methods for making the same and uses thereof  
Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors,...
6180610 Tetrapeptide  
The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same...
6180605 Composition with enhanced osteogenic potential, method for making the same and therapeutic uses thereof  
The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may...
6179872 Biopolymer matt for use in tissue repair and reconstruction  
Biopolymer matt, biopolymer matt composites, biopolymer matt compositions, and methods of preparing the matt and composite matts are described. Also described are biocompatible constructs which...
6177544 Collagen-based auxiliary agent for ophthalmic surgery  
An auxiliary agent for ophthalmic surgery is based on collagen and, after the completion of surgery, undergoes a lowering in viscosity, and thus can be easily removed. This agent is a neutral...
6171827 Procollagens  
There is disclosed molecules comprising at least a first moiety having the activity of a procollagen C-propeptide and a second moiety selected from any one of the group of an alien collagen...
6165983 Use of collagen for the treatment of degenerative articular processes  
The invention relates to the use of collagen for the production of a drug for the treatment of degenerative articular processes. An injection suspension is preferably produced, which contains...
6166184 Process for making a bioprosthetic device  
Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of...
6162247 Vascular graft impregnated with a heparin-containing collagen sealant  
A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without...
6162895 Peracylated insulin compositions and process for making the same  
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or...
6160096 Regenerated collagen fiber and method of manufacturing the same  
The present invention provides a regenerated collagen fiber exhibiting a draping, luster and feel close to those of a natural protein fiber such as a human hair and capable of application of a...
6156531 Cross-linking tissue with a compound having a C.sub.8 to C.sub.40 aliphatic chain  
Collagen-containing tissue is cross-linked to provide tissue suitable for use in production of bioprosthetic devices. A cross-linking agent is used having an aliphatic component containing about 8...
6149946 Method and product using sturgeon notochord for alleviating the symptoms of arthritis  
This invention provides a composition comprising notochord and extracts thereof in therapeutic amounts. The invention more specifically relates to a method of treating arthritis in mammals, more...
6143511 Sandwich immunoassays for collagen type II degradation products  
Sandwich immunoassays for detecting analyte indicative of type II collagen resorption in vivo, by contacting a body fluid sample with a first antibody and a second antibody such that analyte...
6127523 Type IX collagen and fragments thereof  
The present invention relates to novel collagens and polynucleotide sequences encoding these novel proteins. The present invention further relates to specific collagens and derivatives,...
6127143 Preparation of purified and biocompatible collagen using two proteolytic enzyme treatments and a reducing agent  
Purified collagen is produced by a method containing steps of contacting a collagen sample with a first proteolytic enzyme followed by contacting with a reducing agent and a second proteolytic...
6121002 Method to detect bone and other connective tissue disorders in humans and animals  
The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free...
6117646 Assaying protein fragments in body fluids  
Type I collagen degradation products are assayed in a body fluid by conducting a competition immunoassay in which sample molecules compete with a peptide or isomerized peptide in binding to an...
Matches 101 - 150 out of 522 < 1 2 3 4 5 6 7 8 9 10 11 >