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Document Title |
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7591841 |
Implantable devices for accelerated healing
Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
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7572894 |
Templated native silk smectic gels
One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous...
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7504115 |
Shark cartilage extracts and use thereof for immunomodulation
Disclosed is a composition from shark cartilage comprising immunoactive proteoglycans and other immunoactive components having a molecular weight greater than about 100 KD, wherein the composition...
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7462495 |
Methods and compositions for use in diagnosing and characterizing chronic immune disease
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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7393651 |
Confluence regulated adhesion molecules useful in modulating vascular permeability
The invention relates to new polypeptide in isolated form belonging to a subfamily of the human Immunoglobulin Superfamily, which polypeptide shows at least 70% sequence homology with the amino...
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7335739 |
Methods for the purification and aqueous fiber spinning of spider silks and other structural proteins
Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution...
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7285637 |
Method for the preparation of a non-woven silk fibroin fabrics
A process for producing non-woven silk fiber fabrics comprises the following steps: a) obtaining silk fibroin, for example either from silk cocoons, or silk textiles or waste silk; b) removing the...
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7241736 |
Compositions and methods for treating diverticular disease
Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents,...
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7229634 |
Engineered proteins, and methods of making and using
The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.
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7211649 |
Cartilage intermediate layer protein
A novel, N-oligosaccharide-substituted-specific protein of approximately 91.5 kDa was purified from extracts of human articular cartilage and designated Cartilage Intermediate Layer Protein (CILP)....
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7193043 |
Tropoelastin derivatives
The disclosure relates to derivatives of tropoelastin and variants of those derivatives. The disclosure further provides expression products and hybrid molecules of the derivatives and variants of...
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7193038 |
Extraction and utilization of cell growth-promoting peptides from silk protein
Peptides are provided having an excellent safety, stability due to relatively low molecular weights thereof, and cell growth promotion, which are different from cell growth factors produced by...
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7166570 |
Medical implants and fibrosis-inducing agents
Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the...
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7129210 |
Tissue adhesive sealant
A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive...
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7049405 |
α-helical protein based materials and methods for making same
The invention relates to a method of producing useful materials from filament-forming α-helical proteins or filaments made of such proteins. The method comprises allowing filament-forming...
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7041797 |
Precursor silk feedstock for forming filaments
The application relates to a method of obtaining silk feedstock solution from a gland of a silkworm or another silk-producing arthropod in which the body of the silkworm or the other silk-producing...
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6852686 |
Methods for ameliorating icthyosiform skin diseases
The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin...
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6815427 |
Sericin-containing material, process for producing the same method of using the same
The object of the present invention is to elucidate a biologically active function of a component constituting undegraded sericin and to provide a novel medical material, cosmetic material, etc....
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6808707 |
Wound healing compositions and methods using tropoelastin and lysyl oxidase
The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in...
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6765086 |
Self-aligning peptides modeled on human elastin and other fibrous proteins
A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides,...
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6743435 |
Processing animal tissues by decellularizing, increasing surface area and acylating
Methods are provided for processing and dispersing animal tissues that involve exposing processed (e.g., decellularized) tissue to an acylating agent, wherein the ratio of acylating agent to wet...
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6689746 |
Use of isolated domains of type IV collagen to modify cell and tissue interactions
The instant invention provides methods and kits for inhibiting angiogenesis, tumor growth and metastasis, and endothelial cell interactions with the extracellular matrix, involving contacting the...
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6682911 |
Laminins and uses thereof
The present invention is based on the discovery of a novel member of the laminin family, laminin 12. Accordingly, the present invention features a purified or isolated preparation or a recombinant...
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6680293 |
Use of isolated domains of type IV collagen to modify cell and tissue interactions
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and...
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6667051 |
Methods for producing elastin, and tropoelastin products for repairing and or replacing tissue
The invention is directed to a method including the steps of providing at least one layer of unlaminated elastin or unlaminated elastin-based materials or unlaminated tropoelastin materials. Then,...
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6642361 |
Isolated cocoon silk protein from Simulium vittatum and nucleic acids encoding such protein
An isolated nucleic acid molecule encoding the cocoon silk protein from the black fly, Simulium vittatum . Also provided are the amino acid sequence derived from the cocoon silk, primers used to...
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6635616 |
Laminin 15
The present invention features a novel member of the laminin family, i.e., laminin 15, the methods of making these molecules, and the methods of using these molecules in treating neural disorders,...
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6620917 |
Method for the purification and aqueous fiber spinning of spider silks and other structural proteins
Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution...
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6521244 |
Body filling material
A body filling agent is formed of a collagen in the form of powder, fiber or gel, and at least one kind of implantable particles selected from a group consisting of implantable polymer and...
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6440729 |
Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen
The instant invention provides methods and kits for inhibiting angiogenesis, tumor growth and metastasis, and endothelial cell interactions with the extracellular matrix, involving contacting the...
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6432706 |
Method for inhibiting angiogenesis and tumors with the isolated NC1 α6 chain monomer of type IV collagen
The instant invention provides methods and kits for inhibiting angiogenesis, tumor growth and metastasis, and endothelial cell interactions with the extracellular matrix, involving contacting the...
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6372228 |
Method of producing elastin, elastin-based biomaterials and tropoelastin materials
A method is provided for producing elastin or elastin-based materials or tropoelastin materials which have a substantially reduced level of calcification. These materials are typically capable of...
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6316221 |
Functional expression of pheromone binding protein
A method which enable to provide sufficient amount of insect OBP, and moreover, to produce on a large scale under the condition of physiological activation is proposed. The functional expression of...
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6296850 |
Apoptosis-related compounds and their use
Apoptosis-related antigenic compounds comprising an exposed antigenic site having the amino acid sequence TBL SEQ ID NO: 1: Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp 1 5 ...
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6274704 |
Peptides derived from the heparin binding domain of fibronectin
The biologically active peptide of the invention has a number of amino acids of 30 or less, comprises an amino acid sequence described as SEQ ID NO:13 (Tyr Thr Ile Tyr Val Ile Ala Leu) in the...
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6268169 |
Recombinantly produced spider silk
The invention relates to novel spider silk protein analogs derived from the amino acid consensus sequence of repeating units found in the natural spider dragline of Nephila clavipes. More...
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6254986 |
Peracylated protein-based sutures and fabrics and process for making the same
A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or...
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6232458 |
Synthetic polynucleotides encoding tropoelastin
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6184348 |
Functional recombinantly prepared synthetic protein polymer
Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating,...
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6171827 |
Procollagens
There is disclosed molecules comprising at least a first moiety having the activity of a procollagen C-propeptide and a second moiety selected from any one of the group of an alien collagen...
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6090915 |
Collagen or gelatin crumble composition and uses
An animal collagen or gelatin based crumble, and processes for the preparation of the particulate crumble, are useful in the preparation of collagen or gelatin based compositions. The crumble is...
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6034220 |
Chemical modification of repetitive polymers to enhance water solubility
Highly repetitive proteins which are relatively insoluble in water are chemically modified to increase solubility. The protein is reacted with a functionalizing agent to introduce additional polar...
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5986052 |
Fusion polypeptide containing fragments of cartilage matrix protein and link protein
Link protein and cartilage matrix protein, which are two major components of the extracellular cartilage matrix, have been found to bind to each other. Polypeptide fragments of cartilage matrix...
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5955578 |
Polypeptide-polymer conjugates active in wound healing
A conjugate of a synthetic polypeptide containing RGD or (dR) GD and a biodegradable polymer, such as hyaluronic acid or chondroitin sulfate is disclosed. Methods of making the conjugate and using...
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5948891 |
Cytoplasmic modulators of integrin binding
The present invention relates to purified and isolated polynucleotides encoding a polypeptide which specifically bind to a cytoplasmic portion of an integrin. Specifically, the invention provides a...
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5922570 |
Cytoplasmic Modulators of Integrin Binding/Signalling
The present invention relates to purified and isolated polynucleotides encoding a polypeptide which specifically bind to a cytoplasmic portion of an integrin. Specifically, the invention provides a...
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5883227 |
Multiple sclerosis associated polypeptide
The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present...
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5773577 |
Products comprising substrates capable of enzymatic cross-linking
Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences, capable of enzyme catalyzed...
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5763583 |
Process for producing solubilized protein
A process for the production of a solubilized protein is disclosed, which is obtained by reducing disulfide bonds in a disulfide bond-containing water-insoluble protein material into mercapto...
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5756677 |
Minor ampullate spider silk proteins
cDNA clones encoding minor ampullate spidroin proteins (MiSP) are described. The translated amino acid sequence of the cloned cDNA shows that the MiSPs have a structure which exhibits an amino...
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