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5756677 |
Minor ampullate spider silk proteins
cDNA clones encoding minor ampullate spidroin proteins (MiSP) are described. The translated amino acid sequence of the cloned cDNA shows that the MiSPs have a structure which exhibits an amino...
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5728810 |
Spider silk protein
The present invention is directed to isolated cDNA which codes for spider silk protein or a fragment or variant thereof, a replicable vector containing cDNA which codes for spider silk protein and...
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5726040 |
Cosmetic compositions including tropoelastin isomorphs
A cosmetic composition including a non naturally-occurring extracellular matrix protein in combination with a cosmetic carrier is described. The protein is preferably of human origin and has not...
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5705488 |
Injectable compositions for soft tissue augmentation
Injectable implant compositions for soft tissue augmentation comprise elastin and collagen and a biocompatible carrier. An injectable implant composition for soft tissue augmentation is derived...
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5660994 |
Method of detecting tissue-specific, insoluble cytoskeletal proteins
The invention relates to the identification of insoluble cytoskeletal proteins, or fragments thereof, which are characteristic of the origin of the tissue. The invention relates as well to the...
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5629009 |
Delivery system for controlled release of bioactive factors
A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in...
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5606019 |
Synthetic protein as implantables
Copolymers are provided having varying ratios of elastin and fibroin repeating units. By varying the length of segments of the elastin and fibroin repeating units, the absorption can be greatly...
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5604204 |
Method of inducing bone growth using TGF-β
A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of...
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5461034 |
Osteogenic growth polypeptides identified from regenerating bone marrow
A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction....
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5422243 |
Detection of syndecan content in biological materials such as tissues and body fluids for indications of malignant transformations of cells
A method for detecting a potentially detrimental transformation of cells of an organism. The method comprises determining syndecan content indicator from a sample of biological material from the...
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5417975 |
Chemical Compound
The invention provides a process for the preparation of high purity bone mineral wherein the organic matter in degreased bone is degraded and solubilized by heating with ammonia or a primary amine,...
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5416074 |
Artificial biological membrane
The protein materials of the invention are essentially those obtained through reaction of a concentrated aqueous solution of type I and/or type III collagens and elastin or elastin peptides having...
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5412074 |
Silcone modified proteins
Organofunctional silicone chains having an organic moiety on at least one end of the chains, are covalently linked to free amino groups of proteins by the organic moieties to provide a useful...
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5352668 |
Product and method for improving keratinocyte adhesion to the dermis
A purified protein kalinin is disclosed that provides adhesion between epidermal keratinocytes and the underlying dermis. Purified kalinin localizes to the anchoring filaments of basement membranes...
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5328695 |
Muscle morphogenic protein and use thereof
A myogenic protein isolate from mammalian bone is provided that stimulates lineage commitment and differentiation of stem cells in vitro and in vivo. The protein isolate is characterized by its...
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5268269 |
Scleroprotein and scleroprotein hydrolysate containing agent for detection of cholesterol
The present invention provides a diagnostic agent for the enzymatic determination of cholesterol, wherein, besides the necessary enzymes, it contains a scleroprotein or a scleroprotein hydrolysate;...
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5245012 |
Method to achieve solubilization of spider silk proteins
A recombinant spider silk protein can be obtained in a commercially useful form by cloning and the expression in a host cell of a polynucleotide encoding an endogenous spider silk protein or...
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5243038 |
Construction of synthetic DNA and its use in large polypeptide synthesis
Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of...
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5242808 |
Production of bioadhesive precursor protein analogs by genetically engineered organisms
Recombinant production of bioadhesive precursor protein analogs is disclosed. The bioadhesive precursor protein analogs can be hydroxylated and used as an adhesive in wet environments.
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5235041 |
Purification of structurally ordered recombinant protein polymers
Recombinant structural and functional polymers are purified by lysing of the cellular host, separation of the solid materials, washing and extraction of contaminants using a detergent solution at...
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5223420 |
Elastin-based product, a procedure for its preparation and its biological applications; in particular as biomaterials and artificial supports
The subject of the invention is an elastin-based product consisting of an adduct containing elastin and at least one protein which can be coagulated and/or activated by thrombin.
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5206023 |
Method and compositions for the treatment and repair of defects or lesions in cartilage
Methods and compositions are provided for the treatment and repair of defects or lesions in the cartilage of humans and other animals. The defect or lesion in the cartilage may be first treated...
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5202236 |
Method of producing bioadhesive protein
Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from...
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5177020 |
Method for the immunological determination of heparan sulfate-proteoglycan and process for the preparation and purification of heparan sulfate-proteoglycan suitable for this purpose from tissues containing basal membrane
The invention relates to a method for the immunological determination of basal membrane low-density heparan sulfate-proteoglycan in body fluids, and to the preparation or obtaining of a low-density...
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5167961 |
Process for preparing high purity bone mineral
The invention provides a process for the preparation of high purity bone mineral wherein the organic matter is degraded by heating with ammonia or a primary amine, characterized in that the...
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5149657 |
Escherichia coli expression vector encoding bioadhesive precursor protein analogs comprising three to twenty repeats of the decapeptide (Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys)
Recombinant production of a bioadhesive precursor protein analog comprising three, five, ten, fifteen or twenty repeated decapeptides of the formula Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys is...
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5106626 |
Osteogenic factors
The present invention provides an osteogenically active protein preparation characterized by a molecular weight of from about 31,000 to 34,000 daltons as characterized comprising a subunit...
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5089406 |
Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences
This invention relates to processes for the microbial production of peptide oligomers, to polypeptide products resulting from application of any of these processes, and to microbes for use in such...
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5037803 |
Product comprising a silicon organic compound combined with a cosmetically active substance
Process of preparation of an organo-silicon cosmetic compound having cosmetic and cutaneous resorption activity, derived from the addition or combination or complexing of a silanol with a substance...
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4976734 |
Stimulation of chemotaxis by chemotactic peptides
A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formula B 1 -X-(AGVPGLGVG) n -(AGVPGFGVG) m -Y-B 2...
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4963656 |
Emulsified compositions containing elastin hydrolysate
Emulsified compositions comprising an elastin hydrolyzate having a molecular weight not lower than 200,000 (preferably in the range from 1,000,000 to 2,000,000) maintain a stable emulsion state...
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4863854 |
Monoclonal antibodies to mucin-like human differentiation antigens
Three new monoclonal antibodies, MU78, MT334, and MQ49, and the hybridoma cell lines producing these, are disclosed. The antibodies specifically bind to mucin-like antigens with distribution over...
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4842856 |
Parenteral solution
Parenteral solutions comprising (a) a sparingly soluble medicament active compound, (b) a solvent consisting of (i) 5-100 M/V % of an organic solvent or of a mixture of organic solvents...
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4839345 |
Hydrated adhesive gel and method for preparing the same
This invention relates to a hydrated adhesive gel using a product which is obtained by reacting an aqueous solution consisting essentially of protein having amino groups at the side chains thereof,...
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4746729 |
Cartilage-derived leukocyte elastase-inhibitor
A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence...
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4659740 |
Cosmetic preparations comprising novel elastin derivatives
This invention relates to a cosmetic preparation which comprises novel derivatives of solubilized elastin which are fatty acid amides of elastin, and which have been found to permit deeper...
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4614794 |
Protein/polysaccharide complexes
Complexes of polyanionic plant polysaccharides with biodegradable proteins, or proteolytic degradation products thereof, are useful in the formation of wound dressings and surgical implants, such...
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4497862 |
Moisture vapor permeable sheet materials
A moisture vapor permeable sheet material is comprised of a homogeneous admixture of a synthetic polymer material and a protein derivative. The sheet material is moisture vapor permeable and...
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4494994 |
Surface active agent compositions containing polypeptides and lignin sulfonic acid
A surface active agent is comprised of lignin sulfonic acids, and optionally, an alkylaryl sulfonic free acid with at least 10 carbon atoms and a polypeptide having a molecular weight of about...
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4432888 |
Surface active agents based on polypeptides
A surface active agent based upon polypeptides is disclosed. The surface active agent is comprised of the reaction product of an alkyl phenylsulfonic acid and a polypeptide at an acidic pH. The...
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4419288 |
Elastin hydrolyzate
A soluble elastin partial hydrolyzate is comprised of polypeptides having at least 3.5 desmosine and isodesmosine residues/1,000 amino acid residues.
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4402873 |
Extraction of protein from pork bones
Protein is extracted from fresh or cured pork bones to produce an aqueous solution of about 4% to 7% protein, as well as a lard by-product and cooked bone fragments which may be ground and sold as...
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4363760 |
Partially hydrolyzed elastin from limed hide trimmings
A method of preparing soluble partially hydrolyzed elastin is disclosed. The method involves treating insoluble elastin with a peroxide and subsequently partially hydrolyzing the treated elastin...
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4357274 |
Process for the manufacture of sclero protein transplants with increased biological stability
In a process for the manufacture of sclero protein transplants in which raw sclero protein from humans or animals is watered, treated with H 2 O 2 , degreased, rinsed, dried and sterilized, the...
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4325867 |
Process for the recovery of α-2-SB-glycoprotein
The present invention provides a process for obtaining α-2-SB-glycoprotein from physiological solutions thereof by binding to a bindable protein immobilized on an insoluble carrier, wherein the...
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4264493 |
Natural protein polymer hydrogels
Natural protein hydrogel structures formed from natural proteins having molecular weights not exceeding 100,000 by dissolving the protein in an aqueous acidic solution, crosslinking the protein,...
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4233211 |
Finely powdered fibroin and process for producing same
Finely powdered high-purity fibroin and a process for producing the same are disclosed. The fibroin is a fine powder of fibroin in nonfibrous and particulate form which has an average molecular...
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4233212 |
Process for producing a fine powder of silk fibroin
A process for producing a fine powder of high-purity silk fibroin in nonfibrous and particulate form is disclosed. The process comprises dissolving a degummed silk material in at least one solvent...
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4097234 |
Method for preparing dispersion of collagen fiber
A method for preparing an aqueous dispersion of collagen fibers from various materials containing insoluble collagen and various products prepared from the dispersion are disclosed.
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3853940 |
INNER SALTS OF ALKYL ALKOXYALKYL HYDROXYALKYL SULFONIUM SULFATES
Sulfur containing compounds exemplified by ##SPC1## Wherein R and R'" are lower alkyl and R is hydrogen or lower alkyl are useful in treating textiles to improve their crease recovery properties.
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