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7619067 |
Evolved interferon-alpha polypeptides
The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these...
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7619066 |
IL-1ra variants
The present invention provides for an IL-1ra having reduced aggregation, methods of reducing aggregation of IL-1ra, and kits comprising an IL-1ra having reduced aggregation.
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7619065 |
Cystine-knot fold protein
This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this...
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7615615 |
Modified interferon beta with reduced immunogenicity
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ...
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7615531 |
Methods of reducing the likelihood of spontaneous abortion
Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The...
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7615212 |
Compositions and methods for the systemic treatment of arthritis
The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering...
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7611857 |
IL-receptor like molecules and uses thereof
The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists...
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7611705 |
Anti-IL-20 antibody and its use in treating IL-20 associated inflammatory diseases
This invention features an antibody specifically binding to human IL-20 (e.g., mAb 7E and a equivalent thereof) and its use in treating an IL-20 associated inflammatory disease, such as...
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7611700 |
Protease resistant modified interferon alpha polypeptides
Processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided is a rational...
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7608428 |
Polynucleotide encoding an IL-28B polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7608427 |
Polynucleotide encoding an IL-28B polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7608267 |
Multifunctional cytokines
The present invention relates to a novel fusion protein with the formula X—Y, or Y—X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating...
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7601830 |
Polynucleotide encoding mammalian cytokine-like polypeptide-10
A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and...
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7601812 |
Immunomodulating agents from parasitic worms and method for isolation thereof
The invention relates to active agents from parasitic worms, in particular Schistosoma mansoni , which induce a T-helper type 2 response (Th2 immune response).
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7601809 |
Cytokine receptor zcytor19
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used...
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7601514 |
Nucleic acid encoding PRO10268 polypeptides
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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7601341 |
Vascular endothelial growth factor fusion constructs used to inhibit osteoclastogenesis
The 121-amino acid isoform of vascular endothelial growth factor (VEGF 121 ) is linked by a flexible G4S tether to a cytotoxic molecule such as toxin gelonin or granzyme B and expressed as a...
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7598356 |
Method for purifying a protein of the cystine-knot superfamily
The present invention relates to a two-step method for isolating proteins from the cystine-knot superfamily based on dye ligand affinity chromatography and reversed-phase chromatography....
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7598058 |
Nucleic acids encoding IL13 mutants
This invention provides nucleic acid molecules encoding mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13...
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7598050 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7597884 |
Hyperglycosylated polypeptide variants and methods of use
The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more...
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7597883 |
Methods for promoting growth of bone, ligament, and cartilage
Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective...
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7595174 |
Polynucleotide encoding an il-29 polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7595040 |
Deamidated interferon-β
Interferon-β protein analogs in which the asparagine at position 25, numbered in accordance with native interferon-β, is deamidated exhibit a biological activity of native human interferon-β at...
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7595039 |
Methods of healing wounds by administering human IL-18
The present invention relates generally to the use of human IL-18, also known as interferon-γ-inducing factor (IGIF), in the treatment of skin wounds, surgical wounds, leg ulcers, diabetic ulcers,...
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7592425 |
Cytokine zalpha11 ligand fusion proteins
Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino...
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7592311 |
Platelet production promoting agent
The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity...
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7592010 |
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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7589179 |
IL-7 variants with reduced immunogenicity
Modified interleukin-7 (IL-7) polypeptides are disclosed. The modified IL-7 polypeptides have alterations to one or more potential T-cell epitopes, thereby to reduce a T-cell response.
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7588919 |
Polynucleotide encoding an IL-28B polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7588918 |
Polynucleotide encoding an IL-29 polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7585949 |
IL-1 zeta splice variant polypeptide
The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of...
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7585948 |
Soluble interleukin-20 receptor
A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one...
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7585947 |
IL-7 drug substance, composition, preparation and uses
The present invention relates, generally, to the fields of immunology and molecular biology. The invention discloses, more particularly, new and improved interleukin-7 drug substances,...
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7585946 |
Active lymphotoxin-β receptor immunoglobulin chimeric protein compositions
Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification.
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7585943 |
Compositions and methods for fusion protein separation
The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.
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7585496 |
Stable pharmaceutical composition granulocyte-colony stimulating factor
The present invention provides a new stable pharmaceutical composition of granulocyte-colony stimulating factor (G-CSF).
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7582725 |
Agents, which inhibit apoptosis in cells that are involved in wound healing
The invention relates to the use of substances as a fundamental constituent in wound healing agents. The invention is characterised in that said substances bond to either IAP and/or integrin α v...
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7582450 |
Polynucleotide encoding an IL-29 polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7582437 |
Adaptor protein that binds to mammalian toll-like receptor 3, and gene thereof
A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is...
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7579441 |
Cytokine zalpha11 ligand fusion proteins
Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino...
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7579440 |
Mammalian cytokines; related reagents
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are...
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7579439 |
Modulation of IL-2- and IL-15-mediated T cell responses
The present invention is based, in part, on expression studies of IL-2 and IL-15 receptor subunits by cycling T cells in vivo. In one embodiment, the invention generally features novel combinations...
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7578998 |
Chimeric cytokine of IL-7 and beta-chain of HGF and methods of use
The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide...
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7575894 |
Human recombinant beta-interferon with improved solubility
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15),...
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7575742 |
Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R...
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7572891 |
Kidney-specific tumor vaccine directed against kidney tumor antigen G-250
This invention provides an anti-cancer immunogenic agent(s) (e.g. vaccines) that elicit an immune response specifically directed against renal cell cancers expressing a G250 antigenic marker....
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7572886 |
Death associated proteins, and THAP1 and PAR4 pathways in apoptosis control
The invention relates to genes and proteins of the THAP (THanatos (death)-Associated Protein) family comprising a THAP domain, and their use in diagnostics, treatment of disease, and in the...
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7569667 |
Isolated soluble IL-TIF/IL-22 receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules...
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7569215 |
Mutant interleukin-2 (IL-2) polypeptides
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The...
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