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9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9040664 Materials and methods for preparing protein-polymer conjugates  
The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present...
9040055 Conjugation of streptococcal capsular saccharides  
Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive animation of oxidized sialic acid residue side chains is used, but the...
9039994 Biomarkers for myocardial ischemia  
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial...
9040054 Hypoallergenic molecules  
The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues...
9040250 Binding interaction of proanthocyanidins with bacteria and bacterial components  
A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with...
9040478 Derivatisation of granulocyte colony-stimulating factor  
The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200...
9034339 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish  
The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a...
9034345 GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis  
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis...
9034608 Polypeptides with permease activity  
The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO:...
9034318 Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria  
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related...
9034338 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish  
The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a...
9034585 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
9034341 Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions  
The invention relates to methods for controlling the glycosylation of a RAGE fusion protein. The invention also relates to compositions comprising an amount of a RAGE fusion protein where at least...
9034628 Induction of gene expression using a high concentration sugar mixture  
Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
9034586 Method of detecting pancreatic disease and pancreas testing kit  
A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration...
9029505 Modified vasoactive intestinal peptides  
The present invention provides modified Vasoactive Intestinal Peptides (VIPs), encoding polynucleotides and vectors, as well as pharmaceutical compositions comprising the same. The invention...
9029507 Copolymer-1, process for preparation and analytical methods thereof  
The present invention relates to analytical methods such as molecular weight determination of polypeptide, in particular Glatiramer acetate. The present invention further relates to an improved...
9029115 Lipase variants for pharmaceutical use  
The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or...
9029520 B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof  
The present invention relates to the fields of immunology and molecular biology and related to a B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof. Specifically, the DNA...
9028843 Malaria vaccine  
The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and...
9029516 Antibodies and molecules derived therefrom that bind to STEAP-1 proteins  
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and...
9029506 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases  
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use...
9029513 Anti-EGFR antibody and use thereof  
A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope...
9023363 A1 moiety of cholera toxin A subunit as an adjuvant for mucosal and systemic vaccines  
The present invention relates to cholera toxin CTA1 protein fragments, adjuvant compositions, and methods relating to adjuvants for vaccines. The invention also relates to using recombinant CTA1...
9023989 Protein-based photovoltaics and methods of use  
Protein-based photovoltaic cells and the manufacture and use of protein-based photovoltaic cells are described. In one embodiment, bacteriorhodopsin from Halobacterium salinarum, which undergoes...
9023367 Compositions comprising chimeric OSPA molecules and methods of use thereof  
The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA...
9023619 Non-natural gelatin-like proteins with enhanced functionality  
The invention concerns non-natural Gly-Xaa-Yaa-protein monomers and non-natural Gly-Xaa-Yaa-proteins comprising or consisting of multimers of the monomers. The non-natural Gly-Xaa-Yaa-proteins can...
9023633 Chimeric DNA polymerases  
The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one...
9023798 Cystinosin replacement factor  
The present invention provides compositions and methods for providing factor replacement therapy. In particular, the present invention provides replacement therapy for subjects suffering from...
9023604 Method of reversibly staining a target cell  
The present invention relates to methods of reversibly staining a target cell. The invention also relates to methods of isolating a target cell or a target cell population that is defined by the...
9017979 DNA polymerases with improved activity  
Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding,...
9017955 Fibrinogen assay  
The present invention is directed to a method of detecting intact fibrinogen, comprising the steps of: a) providing a sample containing at least some fibrinogen optionally converted at least in...
9017982 Non-wild-type organophosphorus acid anhydrolases for enzymatic decontamination  
Provided are non-wild-type organophosphorus acid anhydrolases that are capable of degrading (ethyl {2-[bis(propan-2-yl)amino]ethyl}sulfanyl) (methyl)phosphinate and other V-agents. Particular...
9018155 Proteins for use in human and animal staphylococcus infections  
The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention...
9017730 Compositions and uses of materials with high antimicrobial activity and low toxicity  
Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo...
9017655 Bispecific EGFR/IGFIR binding molecules  
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The...
9017962 Intracellular reporters  
The invention provides a variety of molecular tools for use in live-cell tracking of activities of biomolecules and in high-throughput drug screening.
9017694 Swine influenza hemagglutinin variants  
The technology relates in part to modified influenza viruses useful for vaccine development. Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin...
9017699 Adjuvancy and immune potentiating properties of natural products of Onchocerca volvulus  
The present invention relates to a method for potentiating a specific immune response to an antigen in a mammal in need thereof. The method comprises administering to the mammal an effective...
9018474 Tomato line CHI 12-94083  
The invention provides seed and plants of tomato line CHI 12-94083. The invention thus relates to the plants, seeds and tissue cultures of tomato line CHI 12-94083, and to methods for producing a...
9018360 Modified biotin-binding protein  
The present invention provides a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2 or its modified sequence and having a biotin-binding activity and...
9012197 Production of hemagglutinin-neuraminidase protein in microalgae  
The present invention is directed to recombinant microalgal cells and their use in production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well as compositions and uses thereof.
9012409 B7-H5, a costimulatory polypeptide  
B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.
9011872 PCV2 immunogenic compositions and methods of producing such compositions  
An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant...
9012393 Fibrin gel for controlled release of PDGF and uses thereof  
The present invention relates, in general, to fibrin sealants, which contain platelet derived growth factor (PDGF) for controlled release in situ for therapeutic applications, including...
9012160 Monitoring skin metabolism products for evaluating burn injury  
The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as...
9012606 In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasng in vivo half-life using same  
The present invention relates to a fusion protein or peptide, the in vivo half-life of which is increased by maintaining in vivo sustained release, and to a method for increasing in vivo half-life...
9005908 Mycobacterial infections  
The present invention relates to Mycobacterial infections and provides a method of diagnosing infections of Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne's...
RE45467 Streptococcus suis polypeptides and polynucleotides encoding same and their use in vaccinal and diagnostic applications  
The present invention relates to the field of Streptococcus. More specifically, the present invention relates to the identification of polypeptides and polynucleotide sequences encoding the same...