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7619071 |
Antibodies that bind interleukin-17 receptor homologue
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
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7619067 |
Evolved interferon-alpha polypeptides
The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these...
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7619066 |
IL-1ra variants
The present invention provides for an IL-1ra having reduced aggregation, methods of reducing aggregation of IL-1ra, and kits comprising an IL-1ra having reduced aggregation.
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7619064 |
Bacillus thuringiensis gene with coleopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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7619063 |
Chimeric immunogens
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for...
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7619062 |
PRO214 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7619061 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7619060 |
Cytoplasmic polyhedrosis virus protein complex of a polyhedrin and a VP3 polypeptide
It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the...
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7618943 |
Fusion polypeptides, and use thereof in antivascular tumor therapy
The present invention relates to fusion polypeptides, comprising at least two peptides. The invention further relates to the use of these fusion proteins in antivascular therapy of neoplastic...
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7618941 |
Treating degenerative joint disorders with tribonectins
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
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7618938 |
Treating cerebrovascular diseases with erythropoietin and granulocyte-colony stimulating factor jointly
A method for treating a cerebrovascular disease with erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF) jointly by first identifying a subject in need of the treatment and then...
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7618935 |
Chaperonin 10 immunosuppression
The invention is directed to the use of cpnl0 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of...
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7618818 |
Method for detecting leptin receptor ligands
The present invention relates to a method for detecting leptin receptor ligands by measuring the energy transfer between fusion proteins comprising a leptin receptor and an energy donor protein or...
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7618782 |
Methods of diagnosing muscle damage
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage,...
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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RE40988 |
Ligands of the neuropeptide receptor HFGAN72
Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or...
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7615623 |
BAG proteins and nucleic acid molecules encoding them
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
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7615622 |
Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII
The present invention provides methods of increasing the half-life factor VIII. More specifically, the invention methods of increasing the half-life of factor VIII by substituting amino acids in...
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7615617 |
Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
A novel approach is described for reversing aggregation and increasing refolding by application of hydrostatic pressure. A protein of interest in an aggregated, or inclusion body, or other...
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7615615 |
Modified interferon beta with reduced immunogenicity
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ...
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7615614 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7615613 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7615612 |
Polypeptide
The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least...
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7615611 |
Human cytokine receptor
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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7615610 |
Modified trafficking patterns for arrestin and G-protein-coupled receptors via arrestin-ubiquitin chimera
The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the...
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7615531 |
Methods of reducing the likelihood of spontaneous abortion
Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The...
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7615360 |
Use of Saccharomyces cerevisiae erg4 mutants for expressing mammalian glucose transporter
The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be...
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7615229 |
Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful...
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7615228 |
Polypeptide fragments of hepatitis E virus, the vaccine comprising said fragments and the diagnostic kits
A purified polypeptide comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of a polymer with n monomeric polypeptides,...
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7612191 |
Polynucleotides encoding interleukin-17 receptor homologue
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
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7612190 |
Method for targeting a polypeptide onto cellular surface
The present invention relates to a polypeptide having an activity for targeting a heterogeneous polypeptide to a surface of cytoplasmic membrane, a nucleic acid encoding the polypeptide, a...
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7612176 |
Polymer-based sustained release device
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically...
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7612175 |
Scavenger receptor
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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7612174 |
Scavenger receptor
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the...
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7612173 |
Vaccine for prevention and treatment of HIV-infection
This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a...
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7612172 |
Nucleic acids and corresponding proteins entitled 282P1G3 useful in treatment and detection of cancer
A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
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7612171 |
DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7612170 |
Co-stimulatory polypeptides
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor...
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7612169 |
Osteoprotegerin variant proteins
The present invention relates to novel osteoprotegerin variant proteins (OVPs) that demonstrate reduced binding affinity for their ligand TRAIL when compared to wild-type osteoprotegerin. Nucleic...
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7612168 |
Modified HIV peptides, antigens, compositions, immunoassay kit and a method of detecting antibodies induced by HIV
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7612167 |
Human hematopoietic growth regulatory gene product
The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The...
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7612163 |
Prokineticin 2β peptide and its use
A PK2β peptide is described, which, as an agonist of prokineticin receptor 1, is useful for treating lung and gastrointestinal diseases or disorders mediated by PKR1 activity.
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7612041 |
Isolated activin-binding ActRIIa polypeptide comprising the SEQ ID NO: 7 and uses for promoting bone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
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7612040 |
Lefty polypeptides and derivatives thereof
The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may...
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7612035 |
Inhibition of mitogen-activated protein kinase (MAPK) pathway: a selective therapeutic strategy against melanoma
Inhibitors of the MAPK pathway, including MEK-directed proteases and small molecule inhibitors, are cytotoxic to human melanoma cells in vitro and in vivo via apoptotic mechanisms. These compounds...
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7611879 |
27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also...
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7611868 |
Recombinant modified adenovirus fiber protein
Recombinant adenoviruses comprising modified fiber proteins which expand the tropism of the adenovirus in comparison to wild-type virus are disclosed. The modified fiber proteins described herein...
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7611867 |
CC-chemokine binding tick proteins
A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus . Compounds prepared in accordance with the present invention can be used as anti-inflammatory and...
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7611858 |
Detection of cannabinoid receptor biomarkers and uses thereof
Traumatic insult to the brain leads to a degradation of low molecular weight of cannabinoid type 1 receptor (CB1) and generation of high molecular weight complexes in the cortex and hippocampus, as...
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7611853 |
Assay to screen for anti-malarials
Malarial parasite Plasmodium falciparum is responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of...
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