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7414110 Human calcium channel compositions and methods  
Isolated DNA encoding each of human calcium channel α 1- , α 2- , β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors...
7414109 FIAT nucleic acids and proteins and uses thereof  
The invention provides FIAT nucleic acids and proteins, and methods of using such nucleic acids and proteins.
7413866 Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors  
The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents...
7413860 Systemic carnitine deficiency gene and uses thereof  
The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting...
7411055 Attractin/mahogany-like polypeptides, polynucleotides, antibodies and methods of use thereof  
The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms...
7411052 Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides  
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like...
7411048 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids  
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a...
7411043 Slo4 potassium channel proteins  
The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel...
7411042 Tumor associated nucleic acids and uses therefor  
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
7411041 DCRS5 polypeptides  
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
7411040 PRO6182 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7410947 Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects  
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
7410789 Process for the fermentative production of S-adenosylmethionine  
A microorganism strain secreting S-adenosylmethionine having increased activity of the cmr (mdfA) gene product is provided.
7410785 ACTR-1, a novel human acyltransferase and uses thereof  
The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic...
7410782 Thermostable enzyme promoting the fidelity of thermostable DNA polymerases—for improvement of nucleic acid synthesis and amplification in vitro  
A purified thermostable enzyme is derived form the thermophilic archaebacterium Archaeoglobus fulgidus . The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double...
7410781 IL-4/IL-13 specific polypeptides and therapeutic uses thereof  
Polypeptides and multimeric polypeptides capable of binding interleukin-4 (IL-4) and interluekin-13 (IL-13) which are useful therapeutically in methods of treating IL-4 and IL-13-related conditions...
7410779 Fusion polypeptides of human serum albumin and a therapeutically active polypeptide  
The invention includes biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for the preparation...
7410777 Non-endogenous, constitutively activated human G protein-coupled receptors  
Disclosed herein are constitutively activated, non-endogenous versions of endogenous human G protein-coupled receptors comprising (a) the following amino acid sequence region (C-terminus to...
7410774 Compounds modulating sister chromatid separation and method for identifying same  
Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity....
7410769 Peptide biosensors for anthrax protease  
The present invention provides a protease biosensor that can be used to detect the presence of the lethal factor protease from Bacillus anthracis, as well as methods for using the protease...
7410648 Polypeptides of Moraxella (Branhamella) catarrhalis  
The present invention relates to polypeptides, more particularly polypeptides of Moraxella ( Branhamella ) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (...
7410647 Antigenic polypeptides  
A method for the identification of antigenic polypeptides, typically opsonic antigens, expressed by pathogenic microbes; vaccines comprising said antigens; and therapeutic antibodies directed to...
7410646 Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine  
Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating...
7410645 Moraxella (Branhamella) catarrhalis antigens  
The present invention relates to polypeptides of Moraxella ( Branhamella ) catarrhalis which may be useful for prophylaxis, diagnosis and/or therapy purposes. 1 ATGGACACTG ACATGAAACA...
7408041 Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof  
Cancer treatments use a therapy that: 1) interferes with the interaction between CD200 and its receptor to block immune suppression thereby promoting eradication of the cancer cells; and 2)...
7408037 Tumor antigen  
Tumor antigen inducing and/or activating HLA-A2-restricted tumor-specific cytotoxic T lymphocytes that is activated by recognizing HLA-A2 and a tumor antigen peptide, and a peptide or polypeptide...
7408036 Human voltage gated sodium channel β1A subunit and methods of use  
DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been...
7408035 PRO9864 polypeptides  
The present invention is directed to novel PRO9864 polypeptides and chimeric polypeptide molecules comprising PRO9864 polypeptides fused to heterologous polypeptide sequences.
7408034 PRO20025 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7408033 PRO5995 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7408032 PRO1188 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7407937 Therapeutic compositions of oncomodulin  
The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of...
7407933 Drug containing angiotensin convertase  
The medicine containing angiotensin-converting enzyme or its peptidase-inactivated mutants that specifically releasing GPI-anchored proteins from the cell surface, for preventing or curing...
7407791 Production of secreted polypeptides  
Described herein are methods and compositions for the production and secretion of polypeptides. Included herein is the use of interrupting peptide transport activity for an increase in polypeptide...
7407789 Recombinant staphylokinase derivatives and the preparation and applications thereof  
The present invention relates to the biotechnology field, more particularly, to novel recombinant staphylokinase (RGD/KGD-Sak) derivatives and the preparation the thereof. The derivatives, have a...
7407785 Human DNase I hyperactive variants  
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
7407783 Fructosylamine oxidase  
The present invention provides a fructosylamine oxidase which is obtainable by culturing Fusarium proliferatum , and purifying two types of fructosylamine oxidase (FAO) with different substrate...
7407776 Engineered zinc finger proteins for regulation of gene expression  
Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome.
7407769 Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide  
Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms,...
7407664 Peptide vaccines against group A streptococci  
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of...
7407659 Methods of diagnosing pre-eclampsia or eclampsia  
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels...
7405290 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer  
A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in...
7405289 Pancreatic islet transcription factor and uses thereof  
The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.
7405286 Stars—A muscle-specific actin-binding protein  
The present invention relates to a new polypeptide and the gene coding therefore, gene being an evolutionarily conserved actin-binding protein, called STARS (striated muscle activator of Rho...
7405279 Chimeric proteins for diagnosis and treatment of diabetes  
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention...
7405278 Chimeric human-type vascular endothelial cell growth factor  
An object of the present invention is to provide a chimera VEGF-E having a reduced antigenicity while maintaining the activity of VEGF-E. The present invention provides a chimera protein having an...
7405273 Chimeric immunogens  
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for...
7405272 Selectin ligand interactor cytoplasmic (SLIC-1), a P-selectin glycoprotein ligand (PSGL-1) binding protein  
The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also...
7405271 Alkaline protease  
An alkaline protease having an amino acid with one or more amino acid residues selected from among those located at (a) position 63, (b) position 89, (c) position 120, (d) positions 63 and 187, (e)...
7405270 CD40-Ligand lacking native-pattern glycosylation  
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
Matches 1 - 50 out of 12556 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >