|
Match
|
Document |
Document Title |
|
|
7563450 |
UL16 binding protein 4
ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells.
|
|
|
7563769 |
FGF variants and methods for use thereof
The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced...
|
|
|
7563871 |
Polymer-based sustained release device
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically...
|
|
|
7563867 |
PRO4356 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7563883 |
Recombinant P. falciparum merozoite protein-142 vaccine
In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-1 42 . The method of the present invention produces a highly purified protein...
|
|
|
7563868 |
NRIF3, a novel co-activator for nuclear hormone receptors
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is...
|
|
|
7563879 |
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invetion relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also realtes to an isolated nucleic acid encoding the leafhopper ecdysone receptor...
|
|
|
7563869 |
Substance specific to human PD-1
The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing...
|
|
|
7560261 |
Nucleic acid sequences encoding CEL II endonuclease
The present invention relates to isolated nucleic acid sequences encoding CEL II endonuclease and vectors and host cells for producing a protein encoded thereby.
|
|
|
7560530 |
IL-33 receptor
Provided herein are methods of modulating IL-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing IL-33...
|
|
|
7560528 |
Method of producing recombinant DNA molecules
The present invention is directed to an improved method for producing by recombinant methods proteins that occur in nature in two or more subunits; more specifically applicable to proteins that...
|
|
|
7560532 |
Smad6 and uses thereof
The invention includes nucleic acids encoding the Smad6 protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by...
|
|
|
7560102 |
Method for reducing neuronal degeneration so as to ameliorate the effects of injury or disease
Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, either the central nervous system or the...
|
|
|
7560232 |
Methods of capturing, detecting and quantifying RNA:DNA hybrids and a modified RNase H useful therein
Methods for specific RNA capture, detection and quantification are presented utilizing a protein that selectively binds RNA:DNA hybrids, preferably an RNase H that is modified to reduce degradation...
|
|
|
7560529 |
Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence
A method for producing catalytic antibodies to proteins and peptides, in particular to gp120, using animals having spontaneous and induced autoimmune pathologies. The method makes it possible to...
|
|
|
7560250 |
Soluble fusion proteins comprising heterologous polypeptides
A soluble fusion protein is disclosed. The soluble fusion protein comprises at least one soluble polypeptide and a heterologous polypeptide being fused thereto, the heterologous polypeptide being...
|
|
|
7560230 |
Method for determining susceptibility of tumor to treatment with anti-neoplastic agent
The level of one or more glucose transporters in a sample containing cancer cells is measured and compared to a reference value to determine whether the cancer is susceptible to treatment with an...
|
|
|
7560116 |
Compositions, methods and kits relating to poxvirus subunit vaccines
The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such...
|
|
|
7560426 |
Verotoxin pharmaceutical compositions and medical treatments therewith
Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin...
|
|
|
7560242 |
Metadherin polypeptides, encoding nucleic acids and methods of use
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the...
|
|
|
7560527 |
Modified adenovirus fibre and uses
The invention concerns an adenovirus fiber modified by mutation of one or several residues of the region included between residues 491 and 505 of SEQ ID NO: 1, the viral particles or...
|
|
|
7560248 |
Oxidation-resistant ribonuclease inhibitor
Mutant forms of ribonuclease inhibitor are described which are rendered more resistant to oxidation while retaining affinity for both ribonuclease and angiogenin. The mutant forms have another...
|
|
|
7560441 |
Modified and stabilized GDF propeptides and uses thereof
Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the...
|
|
|
7557187 |
Purified SR-p70 protein
The invention relates to new nucleic acid sequences of the family of tumour-suppressing genes related to the gene for the p53 protein, and to the corresponding protein sequences.
|
|
|
7557192 |
Anti-PRO335 antibodies
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7556920 |
Gene BNO1 mapping to chromosome 16q24.3
An isolated nucleic acid molecule mapping to chromosome 16q24.3 and comprising the nucleotide sequence set forth in SEQ ID Numbers: 1 or 3.
|
|
|
7556955 |
Nucleic acids encoding Candida kefyr cytosine deaminase
A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the ...
|
|
|
7556810 |
Compositions and methods to control angiogenesis with cupredoxins
The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that...
|
|
|
7556925 |
ανβ3 integrin-binding polypeptide monobodies and their use
The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to ανβ3 integrin. Fusion proteins...
|
|
|
7556953 |
Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an N-terminal leader sequence
A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a leader sequence.
|
|
|
7556812 |
Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications
The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective...
|
|
|
7556816 |
Ehrlichia chaffeensis 28 kDa outer membrane protein multigene family
The 28-kDa outer membrane proteins (P28) of Ehrlichia chaffeensis are encoded by a multigene family consisting of 21 members located in a 23-kb DNA fragment in the genome of E. chaffeensis ....
|
|
|
7557083 |
Gastrokines and derived peptides including inhibitors
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for...
|
|
|
7556927 |
Methods for diagnosing, imaging and treating atherosclerotic disease
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL...
|
|
|
7557079 |
Metalloprotease proteins
This invention relates to proteins termed INSP005 a and INSP005 b , herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and...
|
|
|
7557084 |
IL-18 specific polypeptides and therapeutic uses thereof
Fusion polypeptides and multimeric fusion polypeptides capable of binding interleukin-18 (IL-18) with high affinity, as well as nucleic acids encoding the IL-18-specific polypeptides, which are...
|
|
|
7556959 |
Polynucleotide encoding a polypeptide having a larvae growth inhibiting or insecticidal effect on Scarabaeidae insects
Through screening using an antibody to a polypeptide that constitutes a parasporal body in sporangia of Bacillus popilliae and has a larvae growth inhibiting or insecticidal effect on a ...
|
|
|
7557186 |
Chimeric CrylE δ endotoxin and methods of controlling insects
The present invention relates to a chimeric δ endotoxin protein Cry 1E of SEQ ID No. 1 with extraordinarily high insecticidal property and a chimera gene of SEQ ID No. 2 encoding the said chimeric...
|
|
|
7557185 |
Moraxella catarrhalis proteins
Novel antigens of B. catarrhalis are provided, together with their use in vaccines as well as methods of diagnosing and/or detection.
|
|
|
7556817 |
Clostridial toxin activatable Clostridial toxins
The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such...
|
|
|
7557184 |
Isolated staphylococcus DNAX subunit and use thereof
The duplex DNA of chromosomes is replicated in a multicomponent process. A helicase unwinds the DNA, a replicase synthesizes new DNA, and primase repeatedly synthesizes new primed starts on the...
|
|
|
7553931 |
Complement depletion using recombinant human C3-derivatives
The invention provides isolated polypeptides having complement-modulating activity. Specifically, the invention resides in the provision of isolated polypeptides having complement-depleting...
|
|
|
7553639 |
Alpha-synuclein kinase
The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 and GRK6 kinases.
|
|
|
7553494 |
WT1 fusion proteins
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
|
|
|
7553811 |
Methods and compositions for modulating immunity
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The...
|
|
|
7553930 |
BAFF variants and methods thereof
The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further...
|
|
|
7553832 |
Methods and compositions for specific inhibition of protein splicing by small molecules
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the...
|
|
|
7553665 |
Process for the cultivation of mammalian cells producing IL-18BP in serum-free cell culture medium
The invention relates to a process for culturing IL-18BP expressing mammalian cells under serum-free conditions.
|
|
|
7554021 |
Composition and method for self-assembly and mineralization of peptide amphiphiles
The present invention is directed to a composition useful for making homogeneously mineralized self assembled peptide-amphiphile nanofibers and nanofiber gels. The composition is generally a...
|
|
|
7553642 |
Branched neutral amino acid transporters acting as single molecule
It is intended to provide amino acid transporters which act as a single molecule and transport neutral amino acids typified by branched amino acids, and genes thereof. A protein consisting of an...
|