|
Match
|
Document |
Document Title |
|
|
7622552 |
Ligation method
A method of ligating two or more molecules, for example, peptides to peptides or peptides to labels is provided. The method may comprise the steps: a) providing a first oligopeptide having a...
|
|
|
7622446 |
Polypeptides, derivatives and uses thereof
The invention provides a compound having formula X 1 -Arg-Xaa-Arg-X 2 in which X 1 and X 2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the...
|
|
|
7608577 |
Peptidyl ketones as inhibitors of DPIV
The present invention relates to compounds of the general formula 1
and pharmaceutically acceptable salts thereof, to the use of the compounds for the treatment of impaired glucose tolerance,...
|
|
|
7605123 |
Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof
Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular,...
|
|
|
7579444 |
Polymer-factor IX moiety conjugates
Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among...
|
|
|
7579435 |
Somatostatin-dopamine chimeric analogs
Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is:...
|
|
|
7576175 |
Alpha-4 beta-1 integrin ligands for imaging and therapy
The present invention provides α 4 β 1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino...
|
|
|
7572884 |
Method for making acylated polypeptides
The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent...
|
|
|
7572883 |
Somatostatin-dopamine chimeric analogs
Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is:
...
|
|
|
7563866 |
Modular antigen transporter molecules (MAT molecules) for modulating immune reactions, associated constructs, methods and uses
Modular antigen transporter molecules (MAT molecules), which are used as vaccines and for the treatment of allergies, include three modules: a translocation module which brings about transport of...
|
|
|
7563764 |
Antimicrobial peptides based on tripeptide repeats
The invention described herein relates to compositions of novel antimicrobial peptides that comprise hydrophobic and cationic residues, based on monomeric tri-peptide units. The peptides of the...
|
|
|
7547760 |
Peptides and chemical compound for inhibition of SHP2 function
The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to...
|
|
|
7547675 |
Chemically modified polypeptides
The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method...
|
|
|
7538190 |
Methods for the synthesis of two or more dicarba bridges in organic compounds
Described herein are methods for forming two or more dicarba bridges, as well as new compounds containing dicarba bridges.
|
|
|
7537923 |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or...
|
|
|
7534595 |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
The present invention is directed to phenylalanine ammonia-lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity...
|
|
|
7531622 |
Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells
A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or...
|
|
|
7521531 |
Methods for the purification of stable radioiodine conjugates
The present invention is directed toward a method for preparing and purifying a conjugate of a radioiodinated aminopolycarboxylate-appended peptide and a targeting agent. The method involves (A)...
|
|
|
7504092 |
Cosmetic or pharmaceutical composition comprising peptides, uses and treatment processes
A peptide, with the sequence (AA)n-Arg-Gly-Ser-(AA)n, where (AA) is any amino acid or a derivative thereof and n=0 to 3, as an active ingredient in or for the preparation of a cosmetic and/or...
|
|
|
7498406 |
Substantially cell membrane impermeable compound and use thereof
The present invention relates to a compound according to Formula (I): A-(L-Y) p , wherein A comprises at least one substantially cell- membrane impermeable pendant group; L comprises any suitable...
|
|
|
7495115 |
Steroid conjugates, preparation thereof and the use thereof
Conjugates comprising one or more steroids conjugated with one or more mammalian proteins are disclosed. The conjugates are useful for diagnosis or treatment of solid cancer and haematological...
|
|
|
7488794 |
High yield S-nitrosylation process
A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b)...
|
|
|
7482018 |
Use of oligomers and polymers for drug solubilization, stabilization, and delivery
The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action....
|
|
|
7481993 |
Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
The invention relates to a conjugate PT comprising
(a) a peptide P and (b) a targeting moiety T;
wherein the peptide P contains from 4 to 20 amino acid residues with optionally a single thiol...
|
|
|
7473532 |
Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for...
|
|
|
7465783 |
Plant peptide with antimicrobial activity
The invention concerns novel peptides, in particular plant peptides, having an antimicrobial activity and a cytotoxic activity, in particular for plant cells. The invention also concerns...
|
|
|
7462690 |
Peptide amidation process
The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X 1 -cysteine sequence, wherein X1 is the amino acid at the peptide...
|
|
|
7462689 |
Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or...
|
|
|
7459522 |
Peptide dimers as agonists of the erythropoietin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
|
|
|
7452528 |
Peptide-based carbon nanotube hair colorants and their use in hair colorant and cosmetic compositions
Peptide-based carbon nanotube hair colorants are described. The hair colorants are prepared by coupling hair-binding peptides to the surface of chemically functionalized carbon nanotubes. Hair...
|
|
|
7449544 |
p21 peptides
The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides...
|
|
|
7449445 |
Conductive peptide nanofiber and method of manufacture of the same
A peptide nanofiber having conductivity is provided. A conductive peptide nanofiber which includes a nanofiber formed through a manner of self-assembly of a peptide that has a nanofiber-forming...
|
|
|
7445784 |
Polypeptide for the treatment of cancer and a method for preparation thereof
This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an...
|
|
|
7442764 |
Reversible modification of amine-containing compounds
An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo...
|
|
|
7435716 |
Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing...
|
|
|
7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
|
|
|
7432239 |
Polyoxyalkylene compound and method for making
A process for forming a conjugate of a polyoxyalkylene polymer, such as polyethylene glycol, with a compound containing an amine group(s) and/or a sulfide group(s) by reacting the compound with an...
|
|
|
7425541 |
Enzyme-cleavable prodrug compounds
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is...
|
|
|
7420035 |
Purification of polypeptides
This invention relates to a process for purifying a polypeptide, a capture tag useful for purifying a polypeptide and a periodate-cleavable amino acid derivative useful for purifying a polypeptide....
|
|
|
7408024 |
Somatostatin antagonists
The present invention is directed to a somatostatin antagonist according to formula (I): A 1 -cyclo {D-Cys-A 2 -D-Trp-A 3 -A 4 -Cys}-A 5 Y 1 , wherein A 1 is an optionally substituted aromatic...
|
|
|
7402652 |
Baclofen conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound is provided that has the formula
NH 2 CH 2 CH 2 CHR 1 C(O)N—R (I)
|
|
|
7402556 |
Prodrugs activated by plasmin and their use in cancer chemotherapy
The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or...
|
|
|
7399860 |
Manufacture of polyglutamate-therapeutic agent conjugates
The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates...
|
|
|
7390875 |
Method for binding, in solution, a peptide and a lipophilic vector and uses thereof
The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists...
|
|
|
7378489 |
Angiotensin derivatives
An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with...
|
|
|
7375085 |
Melanocyte-stimulating hormone inhibitors
In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl...
|
|
|
7368431 |
Polypeptide, the conjugate thereof with doxorubicine and a pharmaceutical composition based thereon
The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the...
|
|
|
7368425 |
Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
The present disclosure teaches analogs of human chemokines and methods of using them in the prevention, treatment, and ameliorization of diseases that can benefit from therapeutic angiogenesis. The...
|
|
|
7364889 |
Catalytically active peptides
A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher...
|
|
|
7361731 |
Peptide derivatives, and their use for the synthesis of silicon-based composite materials
Methods for forming peptide derivatives using functional moieties and peptide derivatives are provided. Further, methods for using peptide derivatives to form silicon-based composite materials and...
|