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9023988 Triazole macrocycle systems  
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their...
9011919 Compositions for targeted delivery of siRNA  
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with...
9006183 Methods of protecting against apoptosis using lipopeptides  
The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.
8999930 Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same  
The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently...
8969294 Glucagon/GLP-1 receptor co-agonists  
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular...
8961985 Immunotherapy against several tumors including neuronal and brain tumors  
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present...
8956604 Conjugates comprising an N-oxime bond and associated methods  
Conjugates comprising a N-oxime bond are disclosed. In one embodiment, a suitable conjugate is represented by the following Formula (I): wherein R′ is derived from a compound comprising at least...
8940690 Synthetic conjugates and uses thereof  
The present disclosure provides a cross-linked material comprising conjugates which include two or more separate affinity ligands bound to a non-polymeric framework, wherein the molecular weight...
8940867 Pan-antiviral peptides  
Methods for preparing viral neuraminidase inhibitors including antiviral peptides by specifically chemically modifying disulfide bonds in precursor molecules. A method of inhibiting viral...
8927500 Peptidomimetic macrocycles  
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary...
8927290 Compositions and methods for the detection of antibodies to native human leukocyte antigen  
Provided herein are compositions comprising native and denatured human leukocyte antigens (HLA) and methods of making said compositions. Also provided herein are methods and kits for the detection...
8916683 Nanostructured physically-associating hydrogels for injectable, responsive, and tough biomaterials  
Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating...
8916169 Enhanced immunogenicity of tumor associated antigens by addition of alphagal epitopes  
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based...
8911967 One pot desialylation and glycopegylation of therapeutic peptides  
The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to...
8912309 Preparation method for caspofungin  
Disclosed is a preparation method for caspofungin, comprising the steps: (a) a compound as represented in Formula 2 and a strong leaving group 5 are mixed to obtain a compound as represented in...
8906850 Crystalline insulin-conjugates  
The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of administering, and methods of making that...
8906848 Aureobasidin derivatives and methods of synthesis  
In general, the invention relates to methods of synthesizing AbA derivatives that are useful for treating infection and amenable to further chemical elaboration. These novel methods are scalable...
8895699 Stabilized compounds having secondary structure motifs  
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds...
8889835 Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites  
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in...
8883968 Method for producing surfactin and salt thereof  
The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid...
8883964 Compositions comprising modified collagen and uses therefor  
The invention provides modified collagen and related therapeutic and diagnostic methods.
8859492 Metallodrugs having improved pharmacological properties, and methods of manufacture and use thereof  
It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through...
8846863 Heat stable protein ingredients  
The subject invention pertains to methods of making crosslinked protein-carbohydrate conjugates (CPCCs) and uncrosslinked protein-carbohydrate conjugates (PCCs) that are heat, pH and salt stable....
8846864 Purification tags of synthetic peptides and proteins  
The present invention relates to a series of compounds useful for effecting purification, in particular for use in purification of synthetic peptides and proteins. The compounds of the invention...
8841414 Targeted delivery of therapeutic peptides by thermally responsive biopolymers  
A compound including a cell penetrating peptide (CPP), an elastin-like polypeptide (ELP), and a therapeutic peptide (TP) can be preferentially directed to a target site by applying hyperthermia....
8828542 Nanoparticles  
Nanoparticles can include a core linked to a polymerizable moiety that can be polymerized, cross-linked or cured. The polymerizable nanoparticles can be included in a composition for a...
8816051 Conjugated biological molecules and their preparation  
Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking...
8796420 Non-natural MIC proteins  
This invention describes soluble, monovalent, non-natural protein molecules that can activate NK cells and certain T-cells to attack specific cellular target cells by attaching the NKG2D-binding...
8785595 Functionalising reagents and their uses  
Reagents and methods for functionalizing polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a...
8759114 Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit  
Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.
8754192 Compositions comprising homogeneously glycosylated erythropoietin  
The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or...
8748575 Therapeutic peptides  
Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino...
8748569 Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope  
The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the...
8742013 Synthesis of lipoamide-grafted high molecular compound and method therefor  
The present disclosure provides polymer compounds binding with lipoamide produced by the reaction of the primary amine group of lipoamide with the carboxy group of polysaccharide compounds such as...
8715986 Stereoisomer peptides, ligand-targeted multi- stereoisomer peptide polymer conjugates, and uses thereof  
The invention provides compounds of the formula Poly-([SP-LI]n-PL-L2) including a collection of 152 peptides useful to create the compounds, and their uses thereof for the treatment of a variety...
8715685 Stereoisomer peptides and their polymer conjugates for HIV disease  
This invention discloses a group of 298 peptides from which several peptides are independently selected and synthesized in their stereoisomer and chemically modified forms, and conjugated to a...
8716472 Tripodal cyclohexane derivatives and their use as carbohydrate receptors  
A tri-podal compound according to formula (I) wherein, each Z is the same and is a substituted or unsubstituted N-heteroaromatic single-, multiple-, or fused-ring; and each A is the same, and can...
8703911 Cytokine receptor peptides, compositions thereof and methods thereof  
The invention provides a pharmaceutical composition including a peptide comprising at least a portion of a chemokine receptor or a G-protein coupled receptor and optionally a cytokine. The...
8703903 Method for quantification of allergens  
The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard...
8680046 Inhibitors of viral integrase and methods of use  
Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing...
8669231 Activation of peptide prodrugs by hK2  
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific...
8658765 Non-natural MIC proteins  
This invention describes soluble, monovalent, non-natural protein molecules that can activate NK cells and certain T-cells to attack specific cellular target cells by attaching the NKG2D-binding...
8653240 Thiosulfonate compound, reversible cationization agent for protein and/or peptide, and method for solubilization  
The object of the present invention is to provide a novel thiosulfonate compound, a reversible cationization agent for protein and/or peptide, which can reversibly cationize a wider range of...
8648041 Double-acylated GLP-1 derivatives  
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue...
8647628 Peptide epitopes of apolipoprotein B  
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
8642043 Peptide epitopes of apolipoprotein B  
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
8642726 Peptide epitopes of apolipoprotein B  
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
8623995 Peptide conjugates and fluorescence detection methods for intracellular caspase assay  
Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and...
8609613 Methods of inhibiting type 2 vascular endothelial growth factor receptors using polypeptides  
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated...
8604127 Conjugate of catechol-modified polyethylene glycol with protein or peptide and preparation method thereof  
The present invention relates to a conjugate of a protein or peptide with a polyethylene glycol derivative having catechol, wherein the protein or peptide is mono-PEGylated at the N-terminal with...