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7625996 |
Method for the production of conjugates of insulin-like growth factor-1 and poly(ethylene glycol)
The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the...
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7612166 |
Fluorous capping reagents and methods for peptide purification
Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect...
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7612165 |
Solid-phase synthesis is a capillary
The invention provides, inter alia, methods for synthesizing a molecule on the channel surface of a capillary, comprising the steps of: (i) covalently attaching a first chemical entity to the...
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7608684 |
Soluble CD14 antigen
There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3):
1) a molecular...
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7608583 |
Process for the extraction and isolation of insulin from recombinant sources
The present invention relates to the extraction and isolation of insulins from recombinant sources, particularly those expressed in and secreted by yeasts. Organic solvents have been used to...
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7598047 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7592167 |
Functional peptide fiber, production thereof and method for recovering peptide chains
This invention provides a functional peptide fiber which comprises a plurality of peptide structure units each containing at least one peptide chain, wherein peptide chains contained in each...
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7553832 |
Methods and compositions for specific inhibition of protein splicing by small molecules
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the...
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7550563 |
Method for the purification of a non-immunoglobulin protein comprising an immunoglobulin-like (Ig-like) domain
The present invention relates to a method for the purification of non-immunoglobulin proteins comprising one or more immunoglobulin-like (Ig-like) domain.
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7544512 |
Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs
The present invention discloses a method of producing polypeptides, including insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs, by ligating genes in a tandem way. Also disclosed are the...
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7495072 |
Process for preparation of mixtures of polypeptides using purified hydrobromic acid
The subject invention provides an improved process for obtaining a mixture of polypeptides having nonuniform amino acid sequences, where each polypeptide consists essentially of alanine, glutamic...
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7473532 |
Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for...
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7473679 |
Treatments employing neuronal exocytosis-inhibiting peptides
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain...
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7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
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7438917 |
Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
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7427659 |
Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
The present invention is a process for separating a target protein (such as a recombinant protein produced in a cell culture) from a mixture containing the target protein and contaminants (such as...
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7420035 |
Purification of polypeptides
This invention relates to a process for purifying a polypeptide, a capture tag useful for purifying a polypeptide and a periodate-cleavable amino acid derivative useful for purifying a polypeptide....
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7414106 |
Synthesis of peptide α-thioesters
Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine...
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7405267 |
Method for purifying teicoplanin A2
Disclosed is a method for purifying teicoplanin A 2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a...
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7385029 |
Method of making tetrapeptide derivative TZT-1027 crystal
The invention provides crystals of N 2...
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7354996 |
Method and kit for quantitative analysis of protein
The present invention provides a method for global quantitative analysis of protein that is effectively applied also for unpurified samples such as biological samples, and achieves better detection...
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7335644 |
Anti-hypertensive molecules and process for preparation thereof
The present invention relates to novel anti-hypertensive molecules. The present invention also provides a process for the preparation of novel antihypertensive molecules. The present invention...
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7326769 |
Method for isolating and purifying grass pollen allergens
The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is...
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7326682 |
Conotoxin peptides
The invention relates to an isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such...
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7317002 |
Site-specific preparation of polyethylene glycol-GRF conjugates
A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N α ,...
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7312195 |
Cyclised conotoxin peptides
This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.
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7273846 |
Selective melanin-concentrating hormone type-1 receptor agonists
The present invention features truncated hMCH analogs selectively active at MCH-1R over MCH-2R. Using amino acid numbering provided in hMCH, the featured analogs contain an X 6 which is either a...
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7268210 |
PEG-LHRH analog conjugates
PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also...
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7241735 |
Pharmacologically active polypeptide glycoconjugates
The invention relates to glycopeptidic glycoconjugates, in which the polysaccharide is obtained from Candida utilis cells and the peptides are obtained from Ricinus communis seeds. The...
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7238658 |
Crystallization of IGF-1
Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising...
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7238671 |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or...
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7238779 |
Acyl CoA:cholesterol acyltransferase (ACAT-2)
Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein...
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7232796 |
Medicament containing a tissue inhibitor of metalloproteinases-2 (TIMP-2) as an osteoanabolically active substance
The invention relates to tissue inhibitor of metalloproteinase-2 (TIMP-2) as an osteoanabolically active peptide for use as a medicament for treating bone defects, bone diseases and for improving...
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7223845 |
Synthetic glycosulfopeptides and methods of synthesis thereof
A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a...
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7217784 |
VP1 of foot-and-mouth disease virus
A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1...
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7208573 |
Enrichment of phosphate peptides for proteomic analysis
The present invention is a method, and a kit for carrying out the method, of separating phosphorylated peptides from a mixture of phosphorylated and unphosphorylated peptides. The method involves...
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7199099 |
Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria
A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The...
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7193041 |
Method for purification of recombinant proteins
Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation...
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7183374 |
Method of removing transition metals
A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound....
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7179889 |
Propionicin T1 polypeptide, a bacteriocin from Propionibacterium thoenii
Propionicin T1 has been isolated from Propionibacterium thoenii and both the genetic operon and the products encoded thereby have been characterized. The operon contains two genes: one that...
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7176182 |
Methods of enhancing functioning of the large intestine
The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2...
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7160862 |
Integrin binding motif containing peptides and methods of treating skeletal diseases
Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan...
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7160549 |
Methods for making compositions including gram negative microbial polypeptides
The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative...
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7157553 |
High throughput assays for the proteolytic activities of clostridial neurotoxins
In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic...
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7153832 |
Compositions of active Wnt protein
Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved...
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7138490 |
Block copolymer reduced in impurity content, polymeric carrier, pharmaceutical preparations in polymeric form and process for the preparation of the same
A process for purification which permits satisfactory removal of impurities from a block copolymer consisting essentially of polyethylene glycols and poly(acidic amino acid) and is suitable for the...
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7138487 |
Extractive purification of lipopeptide antibiotics
The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high...
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7135319 |
Crystals of an acyl carrier protein synthase/acyl carrier protein complex
This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of...
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7132505 |
Polypeptide inhibiting a proton-gated Na+ channel, a nucleic acid coding for such polypeptide and a method of manufacturing an ASIC1a channel blocker
The invention relates to a substantially pure polypeptide functioning as an ASIC1a channel blocker. Also provided is a nucleic acid molecule coding such polypeptide, pharmaceutical composition...
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7122628 |
Process for the synthesis of a peptide having a Trp residue
A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a...
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