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9029504 Fluorene compound  
Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.
8969524 FVIII peptides for immune tolerance induction and immunodiagnostics  
The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore,...
8877892 Conjugation reactions  
We describe methods that allow either carbodiimides or other carboxyl-reactive substances to be mixed with solutions of carboxylic acids or phosphates or amines or combinations thereof, so as to...
8784777 Flexibly labeling peptides  
A solid phase peptide synthesis method for synthesizing a peptidyl contrast agent is disclosed. In one example, the method includes synthesizing an amino-chelator loaded resin, coupling of the...
8716439 Method of producing peptide  
The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition...
8691941 Method for producing peptide  
Peptides may be produced by using (A) a first amino acid or peptide, which is converted into its ionic liquid form through the formation of an ionic bond, as a substance serving as both a reaction...
8569453 Fluorene compound  
Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.
8546528 Skin or hair binding peptides  
The invention is directed to peptides. Specifically, the invention is directed to peptides which bind skin and do not bind hair. Alternatively, the invention is drawn to peptides which bind hair...
8546526 Selective αvβ3 receptor peptide antagonist for therapeutic and diagnostic applications  
The present invention is related to new peptide antagonists of αvβ3 receptor, designed on the basis of the crystal structure of integrin αvβ3 in complex with c(RGDf[NMe]V) and the NMR structure of...
8362204 Methods for the synthesis of two or more dicarba bridges in organic compounds  
Described herein are methods for forming two or more dicarba bridges, as well as new compounds containing dicarba bridges.
8344103 Compatible-multiphase organic solvent system  
A solvent system which comprises two or more single organic solvents or two or more mixed organic solvents, characterized in that the state of the solvent system can be reversibly changed, with...
8314209 Lipid-assisted synthesis of polymer compounds and methods for their use  
The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the...
8247533 Beta helical peptide structures stable in aqueous and non-aqueous media  
Disclosed are peptide structures that are stable in aqueous and non-aqueous media where a first linear peptide chain comprising alternating D,L- or L,D-amino acids having an N and C termini is...
8227571 Insulinotropic peptide synthesis using solid and solution phase combination techniques  
The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing...
8217142 Liquid phase peptide synthesis of KL-4 pulmonary surfactant  
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to...
8163874 Beta helical peptide structures stable in aqueous and non-aqueous media and methods for preparing same  
Disclosed is a method of making peptide structures that are stable in aqueous and non-aqueous media where a first linear peptide chain comprising alternating D,L- or L,D-amino acids having an N...
8044173 Asymmetric synthesis of peptides  
A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the...
8021570 β-peptide lyotropic liquid crystals and methods of manufacture and use thereof  
The present invention provides materials and methods that make liquid crystal phases accessible with relatively short β-peptides in aqueous solvents.
8022181 Composition and method for the release of protected peptides from a resin  
The present invention provides a composition and a method for cleaving a peptide from a solid support resin. Hydrochloric acid in an organic water miscible solvent is used to cleave the...
7919580 Polysaccharide-protein binding model and nano-fibril formation of a starch binding domain  
A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid...
7820162 Methods for chemically synthesizing immunoglobulin chimeric proteins  
The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
7718598 Auxiliary for amide bond formation  
This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in...
7589170 Synthesis of cyclic peptides  
This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in...
7576059 Peptide derivatives  
A pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a...
7566697 Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides  
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the...
7449547 Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate  
A process for the total synthesis of Distamycin, and synthetic poly-(4 aminopyrrole-2-carboxamide) congeners thereof, using 1-methyl-4-forinylamino-2-pyrrolecarbonyl chloride iteratively as an...
7435791 Process for rapid solution synthesis of peptides  
The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d): (a) a coupling step, using an excess of an...
7427678 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method  
This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides,...
7396903 Process for preparing insulin compounds  
A preferred way of converting insulin precursors into insulin compounds is to perform an enzymatic peptide cleavage in an aqueous medium and, thereafter, without removal of the intermediate...
7381408 Methods for chemically synthesizing immunoglobulin chimeric proteins  
The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
7329727 Methods and compositions for controlled polypeptide synthesis  
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of...
7268210 PEG-LHRH analog conjugates  
PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also...
7214768 Echinocandin process  
This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Pat. No. 5,378,804. The process involves the...
7192713 Stabilized compounds having secondary structure motifs  
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds...
7084250 Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides  
The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalanin amides of the formula I, in which the anions X are physiologically...
7053055 Compounds of unstable DP IV-inhibitors  
Novel compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The compounds can be used...
6982315 Process for the preparation of carboxamides  
The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine...
6939946 Ring modified cyclic peptide analogs  
A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the...
6897289 Peptide synthesis procedure in solid phase  
A procedure for the solid phase peptide synthesis (SPPS), following a linear or convergent strategy, wherein the peptides contain the sequence of general formula (I), wherein n, Y, X and A1 to An...
6878557 Logically ordered arrays of compounds and methods of making and using the same  
A method for constructing an array of synthetic molecular constructs, by forming a plurality of molecular constructs having a scaffold backbone of a chemical molecule comprising a linear, branched...
6864357 Process for the preparation of peptides  
The present invention relates to a process for the preparation of peptides using an excess of an activated carboxylic component to acylate an amino component, wherein after the acylation an amine...
6849710 Method for the synthesis of analogs of parathyroid hormone and parathyroid hormone related peptide  
A fragment condensation process for the synthesis of analogs of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), in which amino acid residues (22-31) form a synthetic...
6822074 Process for the preparation of cyclo(Asp-DPhe-NMeVal-Arg-Gly)  
Process for the preparation of the cyclic pentapeptide cyclo(Arg-Gly-Asp-DPhe-NMeVal)by cyclization of a linear pentapeptide selected from the group consisting...
6762281 Process for preparing peptide derivatized oligomeric compounds  
Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the...
6750312 Process for the preparation of supports for solid phase synthesis  
A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a...
6686445 Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same  
A composition of matter, denominated herein as 12a-r, having the structural formula set forth below: wherein R is selected from the group consisting of:a) R=NHPh;b) R=NHCH2Ph;c) R=NH(CH2)2Ph;d)...
6664372 Azatide peptidomimetics  
Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means...
6610655 Pentapeptide with specific conformation, its production and use  
Cyclic pentapeptides are disclosed having the following formula (I)-Cyclo(-A1-A2-A3-A4-A5-)-wherein A1, A2, A3, A4 and A5 are amino acid residues. The pentapeptide has amino acid residues in...
6596867 Tartrate salt of a substituted dipeptide as growth hormone secretagogue  
This application relates to processes for making compounds of formula I, and processes for making intermediates useful in the processes for making compounds of formula I.
6566329 Freeze-dried preparation of human growth hormone  
A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method...

Matches 1 - 50 out of 202 1 2 3 4 5 >