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7615368 |
Microarrays of polypeptides
Microarrays of polypeptides on a solid support are provided. The microarray compositions find use in the multiplexed detection and quantitation of ligands, e.g. antigens or antibodies, in a...
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7598343 |
Pharmaceutical formulations of bivalirudin and processes of making the same
Pharmaceutical batch(es) or pharmaceutical formulation(s) comprising bivalirudin as the active ingredient, and a method of preparing the pharmaceutical batch(es) or pharmaceutical formulation(s)....
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7582728 |
Microwave-assisted peptide synthesis
An instrument and method for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase...
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7582727 |
Pharmaceutical formulations of bivalirudin and processes of making the same
Pharmaceutical batch(es) or pharmaceutical formulation(s) comprising bivalirudin as the active ingredient, and a method of preparing the pharmaceutical batch(es) or pharmaceutical formulation(s)....
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7566697 |
Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the...
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7507791 |
Solid phase peptide synthesis of tri-peptide derivatives
The present invention relates to a process for the preparation of a peptide derivative, and more preferably tri-peptide derivatives, of the formula
wherein Tos has the meaning of...
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7473679 |
Treatments employing neuronal exocytosis-inhibiting peptides
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain...
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7459522 |
Peptide dimers as agonists of the erythropoietin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
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7452856 |
Antibacterial peptide
The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or...
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7425608 |
Method of making metallopeptides
Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs,...
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7423117 |
Surface-functionalized carrier material and solid phase synthesis method
The invention concerns a novel surface-functionalized carrier material with a polymeric surface and at least one linker compound according to the general formula (I), which is covalently bound to...
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7414107 |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a...
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7414106 |
Synthesis of peptide α-thioesters
Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine...
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7393920 |
Microwave-assisted peptide synthesis
An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase...
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7388089 |
Anti-arthropod vector vaccines method of selecting and uses thereof
The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent...
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7381408 |
Methods for chemically synthesizing immunoglobulin chimeric proteins
The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
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7375085 |
Melanocyte-stimulating hormone inhibitors
In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl...
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7314708 |
Method and apparatus for electronic synthesis of molecular structures
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
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7312195 |
Cyclised conotoxin peptides
This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use.
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7273846 |
Selective melanin-concentrating hormone type-1 receptor agonists
The present invention features truncated hMCH analogs selectively active at MCH-1R over MCH-2R. Using amino acid numbering provided in hMCH, the featured analogs contain an X 6 which is either a...
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7268210 |
PEG-LHRH analog conjugates
PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also...
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7259142 |
Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
A compound of formula:
in which (i) aa 1 is Adi and aa 4 is Glu or (ii) each of aa 1 and aa 4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates)...
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7247701 |
Amino amides, peptides and peptidomimetics
Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and...
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7244815 |
Attachment and elaboration strategies for inverse peptide synthesis
The present invention provides a process for preparing a peptide of formula I):
Sub-[L]-[N(R 1 )-A-C(O)] p —[NH-A-C(O)] n+m —OH ...
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7214769 |
Method for inverse solid phase synthesis of peptides
The present invention provides a process for preparing a peptide of formula (I):
Sub-[L]-[NH-A-C(O)] n+m —OH (I)
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RE39606 |
Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is...
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7192713 |
Stabilized compounds having secondary structure motifs
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds...
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7176282 |
Solid-phase peptide synthesis and agent for use in such synthesis
The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents, which are useful in solid-phase peptide synthesis.
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7166696 |
Solid phase synthesis supports and methods
Functionalized supports and methods for solid phase synthesis. Preferably, the functionalized support is azlactone-functionalized.
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7160862 |
Integrin binding motif containing peptides and methods of treating skeletal diseases
Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan...
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7153933 |
Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same
A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid...
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7138489 |
Method for producing a modified peptide
The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment...
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7122628 |
Process for the synthesis of a peptide having a Trp residue
A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a...
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7119064 |
Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
The present invention provides methods that utilize compositions containing colostrinin, a constituent peptide thereof, an active analog thereof, and combinations thereof, as modulators of...
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7109162 |
Plant derived antioxidants
The present invention relates to a purified antioxidant polypeptide, a method of isolating and purifying said polypeptide, and method of enhancing antioxidant properties of a composition comprising...
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7094871 |
Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments...
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7094609 |
Spatially addressable combinatorial chemical arrays in encoded optical disk format
A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed...
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7091314 |
Intermediates and methods for making heptapeptide oxytocin analogues
More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin...
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7083914 |
Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of...
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7070936 |
Method for designing protein kinase inhibitors
The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase...
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7067326 |
Synthetic receptors, libraries and uses thereof
Libraries of synthetic receptors are disclosed. The receptors include a polyfunctional organic template which is covalently linked to two or more oligomers. The oligomers may be the same or...
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7060673 |
Fusion peptide of human parathyroid hormone derived peptide and tat peptide, preparation thereof, and skin slimming cosmetic composition comprising the same
The present invention relates to a fusion peptide wherein a self cell-penetrating Tat peptide having a self penetrating signal is bound to a human parathyroid hormone-derived peptide, a preparation...
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7049293 |
Peptide and osteogenetic accelerator
A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or...
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7045503 |
Radiometal-binding peptide analogues
Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand...
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7030217 |
Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments...
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7030216 |
Peptoids incorporating chemoselective functionalities
Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are...
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7026114 |
Methods and compositions for monitoring polymer array synthesis
VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in...
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7015192 |
Neuronal exocytosis inhibiting peptides and cosmetic and pharmaceutical compositions containing said peptides
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain...
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7001883 |
Cyclized conotoxin peptides
This invention relates to cyclized conotoxin peptides, processes for their preparation and their pharmaceutical use.
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6995136 |
Peptide fragments of murine epidermal growth factor as laminin receptor targets
A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from...
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