Matches 201 - 250 out of 527 < 1 2 3 4 5 6 7 8 9 10 11 >
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5917016 Photolabile compounds and methods for their use  
Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.
5891418 Peptide-metal ion pharmaceutical constructs and applications  
A peptide is provided for use as a diagnostic imaging, radiotherapeutic, or therapeutic agent, which peptide has a conformationally constrained global secondary structure obtained upon complexing...
5891995 Substituted benzhydrylamines as handles for solid phase peptide synthesis  
The present invention is directed to a novel "handle" for solid phase peptide synthesis. The handles can be converted from a stable form to a labile form, allowing for cleavage of a peptide amide...
5882645 Peptide compounds  
Synthetic peptides are widely used to generate antibodies. To induce high antibody response, it is known to conjugate the peptide to a carrier protein (e.g. KLH, BSA) or to incorporate it into...
5877278 Synthesis of N-substituted oligomers  
A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of...
5872207 N-terminal-marked peptides immobilized on glass beads and method of preparation and method of use thereof  
Peptides or peptides having an amino acid-like moiety in place of an amino acid moiety thereof immobilized on glass beads, especially controlled-pore glass beads, by a C-terminal...
5861477 Cyclic peptide catalysts modeled on enzyme active sites  
PEPZYMES™, chemically synthesized cyclic peptides, modeled on the active sites of naturally-occurring enzymes represented by chymotrypsin, trypsin, lysozyme, ribonuclease, urokinase, tissue...
5859191 Method for the site-specific modification of peptide alpha amines  
A peptide comprising a free terminal alpha amine is treated with an aryl sulfonamide activating agent, resulting in an activated amide. The resulting activated amide is deprotonated with a base and...
5859190 Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein  
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by...
5858534 Method of making and using derivatized paramagnetic polymer beads  
A solid phase magnetic support having a hydrophilic surface, a method of making the support, and a method of using the support for peptide synthesis are provided. The solid phase magnetic support...
5856440 Solid phase process for synthesizing thymosin α.sub.1  
4-methyloxybenzyloxycarbonyl (Moz) is used to protect the alpha amino groups of the amino acids used in solid-phase synthesis of thymosin α 1 . It was found that the Moz group can be removed...
5851494 Solid phase synthesis reaction vessel and method of using the same  
A solid phase synthesis reaction vessel includes a vessel with a first inlet, a second inlet, and an outlet. A first stopcock is disposed within the first inlet and a second stopcock is disposed...
5846841 Motif Libraries  
The invention concerns libraries of chemical compounds, that are useful in medicinal chemistry and related arts, their methods of manufacture and methods of their use. In one embodiment the...
5846731 Peralkylated oligopeptide mixtures  
Linear peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of...
5840841 Method and apparatus for biopolymer synthesis  
Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle...
5840833 Alpha-helix mimetics and methods relating thereto  
There are disclosed alpha-helix mimetics and methods relating to the same for imparting or stabilizing alpha-helicity to a peptide or protein. In one aspect, the alpha-helix mimetics contain...
5840846 Fibronectin binding protein as well as its preparation  
The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.
5830637 Apparatus and methods for detecting antibodies  
A single, unitary, solid phase support apparatus having a planar surface divided into a plurality of separate zone functions to detect antibodies. Each zone has bonded to it, a different peptide...
5831070 Printing oligonucleotide arrays using deprotection agents solely in the vapor phase  
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a...
5817758 P-nitrobenzyl side-chain protection for solid-phase synthesis  
Solid phase supported synthesis of peptides and other molecules using protecting groups comprising p-nitrobenzyl is described.
5817751 Method for synthesis of diketopiperazine and diketomorpholine derivatives  
The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of...
5814700 Method for polymer synthesis in a reaction well  
A method of synthesis for building a polymer chain, oligonucleotides in particular, by sequentially adding monomer units to at least one solid support for growing and immobilizing a polymer chain...
5811515 Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis  
A method for synthesizing conformationally restricted amino acids, peptides, and peptidomimetics by ring closing metathesis. The method includes the steps of synthesizing a peptide precursor...
5807522 Methods for fabricating microarrays of biological samples  
A method and apparatus for forming microarrays of biological samples on a support are disclosed. The method involves dispensing a known volume of a reagent at each selected array position, by...
5807986 Methods of making and screening betide libraries  
Compounds termed "betides" mimic peptides and contain one or more residues of aminoglycine, C α -aminoalanine, aminosarcosine or the like wherein the side chain amino group has been acylated and...
5804563 Synthetic receptors, libraries and uses thereof  
The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and...
5798444 Ligand precursors for incorporation into peptides  
Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and...
5789162 Methods of synthesizing diverse collections of oligomers  
A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate...
5786447 Opioid peptide analogs  
Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use as analgesics. ##STR1##
5786448 Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein  
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds...
5776674 Chemical biochemical and biological processing in thin films  
An optical trap is used to translate a particle through a thin film coating on an optically-flat surface. Preferably, the thin film coating is heterogeneous and the optical trap is used to move the...
5770358 Tagged synthetic oligomer libraries  
A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates...
5770456 Cyclic nucleic acid and polypeptide arrays  
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
5767238 Inverse solid phase synthesis  
This invention relates to a method of inverse solid phase synthesis in which reactants are reacted in solution and a solid phase matrix is used to separate unreacted reactants from desired product.
5763263 Method and apparatus for producing position addressable combinatorial libraries  
Method and apparatus for producing combinatorial position-addressable libraries of different-sequence oligomers or different-substituent small molecule compounds are disclosed. The method employs...
5763170 Method for forming an array of biological particles  
A method for forming and using an array of, e.g., bacteria, yeast or bacteriophage for the purpose of identifying particular constituents thereof. The array is formed by directing a stream of...
5759779 Polynucleotide-array assay and methods  
A method of analyzing the sequence of a polynucleotide analyte. The method includes contacting the analyte with a position-addressable array of oligonucleotides, each anchored to a solid support...
5744102 Solid phase synthesizer  
Solid phase synthesizer and method of use for synthesis of a polymer. The synthesizer has a generally horizontal elongated vessel for holding a solid support and liquid having two ends, each end...
5744305 Arrays of materials attached to a substrate  
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
5738996 Combinational library composition and method  
A combinatorial library composition and method for using the library to construct oligomers effective to bind to a selected ligand is disclosed. The library composition includes at least two sets...
5734018 Peptide mixtures  
A method to obtain selected individual peptides or families thereof which have a target property and optionally to determine the amino acid sequence of a selected peptide or peptides to permit...
5733881 Opioid peptide antagonists  
Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use. ##STR1## The compounds of formula I are useful in therapy, especially as...
5731413 Method of synthesis of peptidyl aldehydes  
This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel! reagents useful therein.
5726243 Mild solid-phase synthesis of aligned, branched triple-helical peptides  
A triple-helical polypeptide of the formula: ##STR1## is provided wherein: Z is Hyp or Pro; each X and Y is an amino acid such that (Gly-X-Y) m is a sequence of a collagen cell adhesion site; said...
5723575 Process for the preparation of backbone cyclic peptides  
Biologically active, backbone-cyclized peptides of the formula: ##STR1## wherein AA! or A 1 A 1 ! is a naturally occurring or synthetic amino acid residue, n or e is an integer of 1-10, m or d...
5717075 Immobilization of polypeptides on a polyvinylidene difluoride membrane containing ENOL ester and sulfonate groups  
A solid support having surface-attached carboxylic acid groups is reacted with an isoxazolium salt to form an activated support having enol ester and sulfonate groups. After washing to remove...
5714127 System for multiple simultaneous synthesis  
A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes,...
5712383 Process for immobilizing nucleic acid probes on polystyrene surfaces  
Nucleic acid probes are immobilized on polystyrene surfaces such as the wells of microtiter plates for use in solution phase nucleic acid sandwich hybridization assays, particularly those using...
5710123 Peptide inhibitors of selectin binding  
The present invention provides novel peptides having as their core region portions of the 109-118 amino acid sequence of P-selectin, E-selectin or L-selectin. The invention also provides...
5710249 Amino acids and processes for making peptides using same  
Methods of making unnatural amino acids are provided which unnatural amino acids can be incorporated into peptides which either inhibit or promote the secretion of gonadotropins by the pituitary...
Matches 201 - 250 out of 527 < 1 2 3 4 5 6 7 8 9 10 11 >